Results 51 to 60 of about 186,066 (336)

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets [PDF]

Diabetes & Metabolism Journal, 2019
Diabetes and obesity have reached an epidemic status worldwide. Diabetes increases the risk for cardiovascular disease and non-alcoholic fatty liver disease. Primary bile acids are synthesized in hepatocytes and are transformed to secondary bile acids in
Jessica M. Ferrell, John Y. L. Chiang
doaj   +1 more source

Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis [PDF]

, 2014
The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling.
Kasioulis, Ioannis, Jackson, Ian J., Botting, C. H., Botting, Catherine H., Kasioulis, I., Syred, H. M., Seawright, Anne, Fuszard, Matthew Alexander, Shirran, Sally, Van Heyningen, V., Tate, Peri, Finch, Andrew, Tate, P., Jackson, I. J., Adams, I. R., Syred, Heather M., Finch, A., Yeyati, P. L., Shaw, J., Shirran, S., Fuszard, M., Adams, Ian R., Shaw, Joseph, Seawright, A., Yeyati, Patricia L., van Heyningen, Veronica   +25 more
core   +1 more source

Importance of RIP140 and LCoR Sub-Cellular Localization for Their Association With Breast Cancer Aggressiveness and Patient Survival

Translational Oncology, 2018
New markers are needed to improve diagnosis and to personalize treatments for patients with breast cancer (BC). Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen ...
Sophie Sixou, Katharina Müller, Stéphan Jalaguier, Christina Kuhn, Nadia Harbeck, Doris Mayr, Jutta Engel, Udo Jeschke, Nina Ditsch, Vincent Cavaillès   +9 more
doaj   +1 more source

Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains

Cell, 2018
Summary RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional liquids, which can mature into aberrant hydrogels composed of pathological fibrils that underpin fatal neurodegenerative disorders.
Lin Guo, Hong Joo Kim, H. Wang, J. Monaghan, F. Freyermuth, Julie C. Sung, K. O'Donovan, Charlotte M. Fare, Zamia Diaz, Nikita Singh, Zi-Chao Zhang, Maura Coughlin, Elizabeth A. Sweeny, M. DeSantis, Meredith E. Jackrel, Christopher B. Rodell, J. Burdick, O. King, Aaron D. Gitler, C. Lagier-Tourenne, U. Pandey, Yuh Min Chook, J. P. Taylor, J. Shorter   +23 more
semanticscholar   +1 more source

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients [PDF]

Brain, 2005
Spinal and bulbar muscular atrophy (SBMA) is an inherited adult onset motor neuron disease caused by the expansion of a polyglutamine (polyQ) tract within the androgen receptor (AR), affecting only males. The characteristic pathological finding is nuclear inclusions (NIs) consisting of mutant AR with an expanded polyQ in residual motor neurons, and in ...
Hiroaki, Adachi, Masahisa, Katsuno, Makoto, Minamiyama, Masahiro, Waza, Chen, Sang, Yuji, Nakagomi, Yasushi, Kobayashi, Fumiaki, Tanaka, Manabu, Doyu, Akira, Inukai, Mari, Yoshida, Yoshio, Hashizume, Gen, Sobue   +12 more
openaire   +2 more sources

Specific nuclear localizing sequence directs two myosin isoforms to the cell nucleus in calmodulin-sensitive manner. [PDF]

PLoS ONE, 2012
BACKGROUND: Nuclear myosin I (NM1) was the first molecular motor identified in the cell nucleus. Together with nuclear actin, they participate in crucial nuclear events such as transcription, chromatin movements, and chromatin remodeling.
Rastislav Dzijak, Sukriye Yildirim, Michal Kahle, Petr Novák, Jarmila Hnilicová, Tomáš Venit, Pavel Hozák   +6 more
doaj   +1 more source

Kap-Centric control of nuclear pores based on promiscuous binding to FG nucleoporins [PDF]

, 2014
Nuclear pore complexes (NPCs) are remarkable molecular machines that perforate the nuclear envelope (NE) in eukaryotic cells and mediate the rapid bidirectional traffic of hundreds of proteins, ribonucleoproteins, and metabolites across the nuclear ...
Wagner, Raphael S.
core   +1 more source

A Study of Cytoplasmic and Nuclear Estrogen and Progestin Receptors in Gynecologic Neoplasms

Endocrinologia Japonica, 1987
A rapid method for simultaneous preparation of cytosol and nuclear estrogen (E) and progestin (P) receptors and their in vitro determination is described. The method was applied to several uterine or ovarian surgical specimens to evaluate their steroid hormone "dependence". The results suggest that low cytoplasmic E receptor levels (ERc) are associated
SAKAMOTO, H., MACLUSKY, N.J., SCHWARTZ, P.E., NAFTOLIN, F., PHIL, D., DEN, K., TAKAGI, S.   +6 more
openaire   +3 more sources

Endothelin-Induced Sarcoplasmic Reticulum Calcium Depletion Waves in Vascular Smooth Muscle Cells [PDF]

, 2011
Agonist-stimulated waves of elevated cytoplasmic Ca2+ concentration ([Ca2+]i ) regulate blood vessel tone and vasomotion in vascular smooth muscle. Previous studies employing cytoplasmic Ca2+ indicators revealed that these Ca2+ waves were generated by a ...
Cornelis van Breemen, Jeremy Hoskins, Arash Y. Tehrani, Mitra Esfandiarei, Yohan Choi, Nicola Fameli, Jeremy G. Hoskins, Arash Tehrani   +7 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source