Results 31 to 40 of about 186,066 (336)

Nucleocytoplasmic Communication in Healthy and Diseased Plant Tissues

Frontiers in Plant Science, 2021
The double membrane of the nuclear envelope (NE) constitutes a selective compartment barrier that separates nuclear from cytoplasmic processes. Plant viability and responses to a changing environment depend on the spatial communication between both ...
Daniel Lüdke, Philipp F. W. Rohmann, Marcel Wiermer, Marcel Wiermer   +3 more
doaj   +1 more source

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals [PDF]

, 2004
BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals.
Urs A Meyer, Handschin, C., Gnerre, C, Sharon Blättler, Meyer, U A, Blattler, S., Handschin, C, Podvinec, M, Oscarson, M., Michael Podvinec, Michel R Kaufmann, Adrian Roth, Kaufmann, M R, Looser, R, Carmela Gnerre, Roth, A., Roth, A, Meyer, U. A., Gnerre, C., Blättler, S, Christoph Handschin, Kaufmann, M. R., Renate Looser, Looser, R., Mikael Oscarson, Oscarson, M, Podvinec, M.   +26 more
core   +1 more source

Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload

Frontiers in Cell and Developmental Biology, 2021
RationaleGq-coupled receptors are thought to play a critical role in the induction of left ventricular hypertrophy (LVH) secondary to pressure overload, although mechano-sensitive channel activation by a variety of mechanisms has also been proposed, and ...
Ze-Yan Yu, Ze-Yan Yu, Ze-Yan Yu, Hutao Gong, Jianxin Wu, Yun Dai, Scott H. Kesteven, Diane Fatkin, Diane Fatkin, Diane Fatkin, Boris Martinac, Boris Martinac, Robert M. Graham, Robert M. Graham, Robert M. Graham, Michael P. Feneley, Michael P. Feneley, Michael P. Feneley   +17 more
doaj   +1 more source

The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane. [PDF]

PLoS ONE, 2010
The mammalian type I gonadotropin releasing hormone receptor (GnRH-R) is a structurally unique G protein-coupled receptor (GPCR) that lacks cytoplasmic tail sequences and displays inefficient plasma membrane expression (PME).
Michelle Re, Macarena Pampillo, Martin Savard, Céléna Dubuc, Craig A McArdle, Robert P Millar, P Michael Conn, Fernand Gobeil, Moshmi Bhattacharya, Andy V Babwah   +9 more
doaj   +1 more source

Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]

Endocrinology and Metabolism, 2021
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
doaj   +1 more source

R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response

Nature, 2022
R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability^ 1 , which has been linked to the action of endonucleases such as XPG^ 2 – 4 .
Madzia P. Crossley, Chenlin Song, M. Bocek, Jun-Hyuk Choi, Joseph Kousorous, Ataya Sathirachinda, Cindy Lin, Joshua R. Brickner, Gongshi Bai, H. Lans, W. Vermeulen, Monther Abu-Remaileh, Karlene A. Cimprich   +12 more
semanticscholar   +1 more source

Estrogen receptor β is associated with expression of cancer associated genes and survival in ovarian cancer

BMC Cancer, 2018
Background In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear.
Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck   +4 more
doaj   +1 more source

Energy- and temperature-dependent transport of integral proteins to the inner nuclear membrane via the nuclear pore [PDF]

, 2004
Resident integral proteins of the inner nuclear membrane (INM) are synthesized as membrane-integrated proteins on the peripheral endoplasmic reticulum (ER) and are transported to the INM throughout interphase using an unknown trafficking mechanism.
Gerace, Larry, Nishimoto, Takeharu, Schirmer, Eric C, Eric C. Schirmer, Ohba, Tomoyuki, Tomoyuki Ohba, Takeharu Nishimoto, Larry Gerace   +7 more
core   +1 more source

The effects of treatment with melatonin on the ultrastructure of mouse leydig cells: a quantitative study [PDF]

Brazilian Journal of Biology, 2002
Both the presence of receptors for gonadal steroids in the pineal gland and in vitro observations of direct action of melatonin upon Leydig cells, inhibiting testosterone secretion, indicate a direct connection between pineal gland and gonadal function ...
C. A. REDINS, G. M. REDINS, J. C. NOVAES
doaj   +1 more source

Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2011 Spandidos Publications Ltd.A vital function of the human placenta is to produce steroid hormones such as ...
Karteris, E, Zachariades, E, Foster, H, Goumenou, A, Thomas, P, Rand-Weaver, M, null Karteris   +6 more
core   +1 more source