Results 11 to 20 of about 166,825 (267)

Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload

Frontiers in Cell and Developmental Biology, 2021
RationaleGq-coupled receptors are thought to play a critical role in the induction of left ventricular hypertrophy (LVH) secondary to pressure overload, although mechano-sensitive channel activation by a variety of mechanisms has also been proposed, and ...
Ze-Yan Yu, Ze-Yan Yu, Ze-Yan Yu, Hutao Gong, Jianxin Wu, Yun Dai, Scott H. Kesteven, Diane Fatkin, Diane Fatkin, Diane Fatkin, Boris Martinac, Boris Martinac, Robert M. Graham, Robert M. Graham, Robert M. Graham, Michael P. Feneley, Michael P. Feneley, Michael P. Feneley   +17 more
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The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane. [PDF]

PLoS ONE, 2010
The mammalian type I gonadotropin releasing hormone receptor (GnRH-R) is a structurally unique G protein-coupled receptor (GPCR) that lacks cytoplasmic tail sequences and displays inefficient plasma membrane expression (PME).
Michelle Re, Macarena Pampillo, Martin Savard, Céléna Dubuc, Craig A McArdle, Robert P Millar, P Michael Conn, Fernand Gobeil, Moshmi Bhattacharya, Andy V Babwah   +9 more
doaj   +1 more source

Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics [PDF]

Endocrinology and Metabolism, 2021
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways ...
Jong Hyeon Yoon, Ki-Sun Kwon
doaj   +1 more source

Estrogen receptor β is associated with expression of cancer associated genes and survival in ovarian cancer

BMC Cancer, 2018
Background In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear.
Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck   +4 more
doaj   +1 more source

Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors

Biology, 2022
RNA-binding proteins (RBPs) with a low-complexity prion-like domain (PLD) can undergo aberrant phase transitions and have been implicated in neurodegenerative diseases such as ALS and FTD.
Amandeep Girdhar, Lin Guo
doaj   +1 more source

The effects of treatment with melatonin on the ultrastructure of mouse leydig cells: a quantitative study [PDF]

Brazilian Journal of Biology, 2002
Both the presence of receptors for gonadal steroids in the pineal gland and in vitro observations of direct action of melatonin upon Leydig cells, inhibiting testosterone secretion, indicate a direct connection between pineal gland and gonadal function ...
C. A. REDINS, G. M. REDINS, J. C. NOVAES
doaj   +1 more source

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.

PLoS Pathogens, 2015
The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammatory cytokines ...
Dipanjan Dutta, Sujoy Dutta, Mohanan Valiya Veettil, Arunava Roy, Mairaj Ahmed Ansari, Jawed Iqbal, Leela Chikoti, Binod Kumar, Karen E Johnson, Bala Chandran   +9 more
doaj   +1 more source

Structural characterisation of TNRC6A nuclear localisation signal in complex with importin-alpha. [PDF]

PLoS ONE, 2017
The GW182/TNRC6 family of proteins are central scaffolds that link microRNA-associated Argonaute proteins to the cytoplasmic decay machinery for targeted mRNA degradation processes.
Jessica J Chaston, Alastair Gordon Stewart, Mary Christie   +2 more
doaj   +1 more source

Relationships between renal cytoplasmic and nuclear aldosterone-receptors

Kidney International, 1972
Relationships between renal cytoplasmic and nuclear aldosteronereceptors.Three 3H-aldosterone receptor complexes have been recovered from rat kidneys: 1) cytosol (high speed supernatants), 2) Tris-soluble nuclear (obtained by an osmotic shock procedure), and 3) chromatin-bound (prepared by extracting post-shock nuclei with 0.4 M KCl).Glycerol density ...
Marver, Diana, Goodman, Daniel, Edelman, Isidore S.   +2 more
openaire   +2 more sources

Evidence for the existence of an oligomeric, non-DNA-binding complex of the progesterone receptor in the cytoplasm

European Journal of Histochemistry, 2009
Steroid receptors are found as a hetero-oligomeric complex in cell extracts. Due to the dynamic interaction between receptor-associated proteins and receptors, it is difficult to study the oligomeric complex in living cells.
S Passinen, T Ylikomi
doaj   +1 more source