Results 41 to 50 of about 82,494 (244)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Signal Recognition Particle Myopathy With Cardiac Manifestations in Rheumatoid Arthritis

Annals of Internal Medicine: Clinical Cases
Immune-mediated necrotizing myopathy is a rare inflammatory myopathy characterized by progressive muscle weakness and potentially severe systemic complications.
Priya Sunkara, Deepesh Yadav, Murat Gokden, Vinisha Kota   +3 more
doaj   +1 more source

Application of Data Particle Geometrical Divide Algorithms in the Process of Radar Signal Recognition

Sensors, 2023
The process of recognising and classifying radar signals and their radiation sources is currently a key element of operational activities in the electromagnetic environment.
Janusz Dudczyk, Łukasz Rybak
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Vibration Test of Single Coal Gangue Particle Directly Impacting the Metal Plate and the Study of Coal Gangue Recognition Based on Vibration Signal and Stacking Integration

IEEE Access, 2019
In order to realize the recognition of coal gangue in the top coal caving process, a scheme of the coal gangue recognition based on the collision vibration signal between coal gangue and the metal plate is proposed in this paper, a systematic and ...
Yang Yang, Qingliang Zeng, Guangjun Yin, Lirong Wan   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome

Nature Communications, 2017
Membrane proteins are inserted co-transnationally through the association between ribosome, the signal recognition particle and its receptor, and the membrane-bound translocon.
Ahmad Jomaa, Yu-Hsien Hwang Fu, Daniel Boehringer, Marc Leibundgut, Shu-ou Shan, Nenad Ban   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Feature Extraction and Attribute Recognition of Aerosol Particles from In Situ Light-Scattering Measurements Based on EMD-ICA Combined LSTM Model

Atmosphere
Accurate identification and monitoring of aerosol properties is crucial for understanding their sources and impacts on human health and the environment.
Heng Zhao, Yanyan Zhang, Dengxin Hua, Jiamin Fang, Jie Zhang, Zewen Yang   +5 more
doaj   +1 more source