Results 21 to 30 of about 81,913 (204)

X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. [PDF]

PLoS ONE, 2007
The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes ...
Christopher L Reyes, Earl Rutenber, Peter Walter, Robert M Stroud   +3 more
doaj   +1 more source

The Dynamic SecYEG Translocon

Frontiers in Molecular Biosciences, 2021
The spatial and temporal coordination of protein transport is an essential cornerstone of the bacterial adaptation to different environmental conditions.
Julia Oswald, Robert Njenga, Robert Njenga, Ana Natriashvili, Ana Natriashvili, Pinku Sarmah, Pinku Sarmah, Hans-Georg Koch   +7 more
doaj   +1 more source

Signal recognition particle prevents N-terminal processing of bacterial membrane proteins

Nature Communications, 2017
Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal ...
Amitabh Ranjan, Evan Mercier, Arshiya Bhatt, Wolfgang Wintermeyer   +3 more
doaj   +1 more source

Real-time observation of signal recognition particle binding to actively translating ribosomes

eLife, 2014
The signal recognition particle (SRP) directs translating ribosome-nascent chain complexes (RNCs) that display a signal sequence to protein translocation channels in target membranes.
Thomas R Noriega, Jin Chen, Peter Walter, Joseph D Puglisi   +3 more
doaj   +1 more source

The nucleolar phase of signal recognition particle assembly

Life Science Alliance
Signal recognition particle (SRP) involved in tethering the ribosome to the endoplasmic reticulum for protein secretion is assembled in part in the nucleolus where it interacts with numerous ribosome assembly factors.
Amani Issa, Florence Schlotter, Justine Flayac, Jing Chen, Ludivine Wacheul, Manon Philippe, Lucas Sardini, Lalia Mostefa, Franck Vandermoere, Edouard Bertrand, Céline Verheggen, Denis LJ Lafontaine, Séverine Massenet   +12 more
doaj   +1 more source

The Identification of ECG Signals Using WT-UKF and IPSO-SVM

Sensors, 2022
The biometric identification method is a current research hotspot in the pattern recognition field. Due to the advantages of electrocardiogram (ECG) signals, which are difficult to replicate and easy to obtain, ECG-based identity identification has ...
Ning Li, Longhui Zhu, Wentao Ma, Yelin Wang, Fuxing He, Aixiang Zheng, Xiaoping Zhang   +6 more
doaj   +1 more source

Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

Nature Communications, 2016
The co-translational insertion of proteins into membranes requires interaction between a ribosome-bound signal recognition particle (SRP) and a membrane-bound translocon.
Ahmad Jomaa, Daniel Boehringer, Marc Leibundgut, Nenad Ban   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Application of Data Particle Geometrical Divide Algorithms in the Process of Radar Signal Recognition

Sensors, 2023
The process of recognising and classifying radar signals and their radiation sources is currently a key element of operational activities in the electromagnetic environment.
Janusz Dudczyk, Łukasz Rybak
doaj   +1 more source