Results 11 to 20 of about 4,406,131 (273)

Recognition of a signal peptide by the signal recognition particle [PDF]

Nature, 2010
Targeting of proteins to appropriate subcellular compartments is a crucial process in all living cells. Secretory and membrane proteins usually contain an amino-terminal signal peptide, which is recognized by the signal recognition particle (SRP) when nascent polypeptide chains emerge from the ribosome.
Janda, C, Li, J, Oubridge, C, Hernández, H, Robinson, C, Nagai, K   +5 more
openaire   +3 more sources

SRPDB: Signal Recognition Particle Database [PDF]

Nucleic Acids Research, 2003
The Signal Recognition Particle Database (SRPDB) at http://psyche.uthct.edu/dbs/SRPDB/SRPDB.html and http://bio.lundberg.gu.se/dbs/SRPDB/SRPDB.html assists in the better understanding of the structure and function of the signal recognition particle (SRP), a ribonucleoprotein complex that recognizes signal sequences as they emerge from the ribosome ...
Magnus Alm Rosenblad, Jan Gorodkin, Bjarne Knudsen, Christian Zwieb, Tore Samuelsson   +4 more
openaire   +5 more sources

Interaction of signal-recognition particle 54 GTPase domain and signal-recognition particle RNA in the free signal-recognition particle [PDF]

Proceedings of the National Academy of Sciences, 2007
The signal-recognition particle (SRP) is a ubiquitous protein–RNA complex that targets proteins to cellular membranes for insertion or secretion. A key player in SRP-mediated protein targeting is the evolutionarily conserved core consisting of the SRP RNA and the multidomain protein SRP54. Communication between the SRP54 domains is
Tobias, Hainzl, Shenghua, Huang, A Elisabeth, Sauer-Eriksson   +2 more
openaire   +3 more sources

Structural basis of signal-sequence recognition by the signal recognition particle

Nature Structural & Molecular Biology, 2011
The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-Å structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker ...
Tobias, Hainzl, Shenghua, Huang, Gitte, Meriläinen, Kristoffer, Brännström, A Elisabeth, Sauer-Eriksson   +4 more
openaire   +3 more sources

Anti‐signal recognition particle antibodies induce cardiac diastolic dysfunction via oxidative stress injury [PDF]

Clinical & Translational Immunology
Objectives Anti‐signal recognition particle (SRP) antibodies, markers of immune‐mediated necrotising myopathy, are reportedly related to cardiac involvement; however, whether they are pathogenic to the myocardium remains unclear.
Hao Zhang, Yunjing Shi, Yingze Fan, Dehao Zhu, Zeping Qiu, Huihui Chi, Qiongyi Hu, Liangzhe Xie, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Zhuochao Zhou, Jianfen Meng, Jialin Teng, Chengde Yang, Wei Jin, Yutong Su   +18 more
doaj   +2 more sources

A signal recognition particle-related joint model of LASSO regression, SVM-RFE and artificial neural network for the diagnosis of systemic sclerosis-associated pulmonary hypertension [PDF]

Frontiers in Genetics, 2022
Background: Systemic sclerosis-associated pulmonary hypertension (SSc-PH) is one of the most common causes of death in patients with systemic sclerosis (SSc).
Jingxi Xu, Jingxi Xu, Chaoyang Liang, Jiangtao Li   +3 more
doaj   +2 more sources

Factors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies [PDF]

Orphanet Journal of Rare Diseases, 2020
Background Autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (ANM-SRP) is regarded as refractory myositis, whereby some patients respond poorly to conventional immunosuppression and require B cell depletion treatment.
Yawen Zhao, Wei Zhang, Yilin Liu, Zhaoxia Wang, Yun Yuan   +4 more
doaj   +2 more sources

Signal Recognition Particle RNA Contributes to Oxidative Stress Response in Deinococcus radiodurans by Modulating Catalase Localization [PDF]

Frontiers in Microbiology, 2020
The proper functioning of many proteins requires their transport to the correct cellular compartment or their secretion. Signal recognition particle (SRP) is a major protein transport pathway responsible for the co-translational movement of integral ...
Runhua Han, Jaden Fang, Jessie Jiang, Elena K. Gaidamakova, Elena K. Gaidamakova, Rok Tkavc, Rok Tkavc, Rok Tkavc, Michael J. Daly, Lydia M. Contreras, Lydia M. Contreras   +10 more
doaj   +2 more sources

New Insights into Signal Recognition and Elongation Arrest Activities of the Signal Recognition Particle

Biological Chemistry, 1999
AbstractThe signal recognition particle (SRP), a ubiquitous cytoplasmic ribonucleoprotein particle, plays an essential role in promoting co-translational translocation of proteins into the endoplasmic reticulum. Here, we summarise recent progress made in the understanding of two essential SRP functions: the signal recognition function, which ensures ...
Bui, Nazarena, Strub, Katharina
openaire   +3 more sources

Recognition model and algorithm of projectiles by combining particle swarm optimization support vector and spatial-temporal constrain

Defence Technology, 2023
In order to improve the recognition rate and accuracy rate of projectiles in six sky-screens intersection test system, this work proposes a new recognition method of projectiles by combining particle swarm optimization support vector and spatial-temporal
Han-shan Li
doaj   +1 more source