Results 31 to 40 of about 82,494 (244)
Signal recognition particle components in the nucleolus [PDF]
Proceedings of the National Academy of Sciences, 2000 The signal recognition particle (SRP) is a ribonucleoprotein composed of an Alu domain and an S domain. The S domain contains unique sequence SRP RNA and four SRP proteins: SRP19, SRP54, SRP68, and SRP72.
Politz, Joan C. Ritland +5 more
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X-ray structures of the signal recognition particle receptor reveal targeting cycle intermediates. [PDF]
PLoS ONE, 2007 The signal recognition particle (SRP) and its conjugate receptor (SR) mediate cotranslational targeting of a subclass of proteins destined for secretion to the endoplasmic reticulum membrane in eukaryotes or to the plasma membrane in prokaryotes ...
Christopher L Reyes +3 more
doaj +1 more source
SRPDB (Signal Recognition Particle Database) [PDF]
Nucleic Acids Research, 2001 Signal recognition particle (SRP) is a stable cytoplasmic ribonucleoprotein complex that serves to translocate secretory proteins across membranes during translation. The SRP Database (SRPDB) provides compilations of SRP components, ordered alphabetically and phylogenetically.
Jan Gorodkin +3 more
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Frontiers in Molecular Biosciences, 2021 The spatial and temporal coordination of protein transport is an essential cornerstone of the bacterial adaptation to different environmental conditions.
Julia Oswald +7 more
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Antibody to signal recognition particle in polymyositis [PDF]
Arthritis & Rheumatism, 1990 AbstractUsing immunoprecipitation, we identified 13 patients with antibodies to the signal recognition particle (SRP) from a collection of sera representing 265 poly‐myositis/dermatomyositis (PM/DM) patients. Antibody reactivity with SRP was confirmed by enzyme‐linked immunosorbent assay and immunoprecipitation with isolated dog pancreas SRP.
I N, Targoff, A E, Johnson, F W, Miller
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Real-time observation of signal recognition particle binding to actively translating ribosomes
eLife, 2014 The signal recognition particle (SRP) directs translating ribosome-nascent chain complexes (RNCs) that display a signal sequence to protein translocation channels in target membranes.
Thomas R Noriega +3 more
doaj +1 more source
Signal recognition particle prevents N-terminal processing of bacterial membrane proteins
Nature Communications, 2017 Bacterial proteins are synthesized with formyl-methionine in their N-terminus, but most of them are co-translationally deformylated. Here, the authors show that inner-membrane proteins are protected from deformylation by the binding of the signal ...
Amitabh Ranjan +3 more
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Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon
Nature Communications, 2016 The co-translational insertion of proteins into membranes requires interaction between a ribosome-bound signal recognition particle (SRP) and a membrane-bound translocon.
Ahmad Jomaa +3 more
doaj +1 more source
The Identification of ECG Signals Using WT-UKF and IPSO-SVM
Sensors, 2022 The biometric identification method is a current research hotspot in the pattern recognition field. Due to the advantages of electrocardiogram (ECG) signals, which are difficult to replicate and easy to obtain, ECG-based identity identification has ...
Ning Li +6 more
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The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source