Results 61 to 70 of about 4,406,131 (273)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of SRP9/SRP14 in regulating Alu RNA

RNA Biology
SRP9/SRP14 is a protein heterodimer that plays a critical role in the signal recognition particle through its interaction with the scaffolding signal recognition particle RNA (7SL).
Daniel Gussakovsky, Nicole A. Black, Evan P. Booy, Sean A. McKenna   +3 more
doaj   +1 more source

Multi-feature radar signal modulation recognition based on improved PSO algorithm

The Journal of Engineering, 2019
In order to solve the problem that radar emitter signal modulation recognition under low signal-to-noise ratio (SNR) has difficulty in selecting the parameters of the classifier and the problem of low recognition rate caused by the improper selection of ...
Jing-Peng Gao, Liang-Xi Shen, Fang Ye, Shang-Yue Wang, Ran Zhang   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A nomenclature for all signal recognition particle RNAs [PDF]

RNA, 2004
The signal recognition particle (SRP) is a cytosolic ribonucleoprotein complex that guides secretory proteins to biological membranes in all organisms. The SRP RNA is at the center of the structure and function of the SRP. The comparison of the growing number of SRP RNA sequences provides a rich source for gaining valuable insight into the composition,
Zwieb C, Van Nues RW, Rosenblad MA, Brown JD, Samuelsson T   +4 more
openaire   +3 more sources

Gene Dosage Analysis on the Single-Cell Transcriptomes Linking Cotranslational Protein Targeting to Metastatic Triple-Negative Breast Cancer

Pharmaceuticals, 2021
Many recent efforts have been put into the association between expression heterogeneity and different cell types and states using single-cell RNA transcriptome analysis.
Yining Liu, Min Zhao
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Yet another job for the bacterial ribosome

Microbial Cell, 2019
The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information,
Andrea Origi, Ana Natriashivili, Lara Knüpffer, Clara Fehrenbach, Kärt Denks, Rosella Asti, Hans-Georg Koch   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Communicating Recognition & Rewards experiences: Tips and tricks

These guidelines support communications and marketing employees in the preparation and execution stages of creating a story about someone’s experiences with Recognition & Rewards (R&R) principles and themes.
Recognition & Rewards
core   +2 more sources