Results 81 to 90 of about 258,150 (276)

Yet another job for the bacterial ribosome

open access: yesMicrobial Cell, 2019
The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information,
Andrea Origi   +6 more
doaj   +1 more source

Feature extraction algorithm of anti-jamming cyclic frequency of electronic communication signal

open access: yesJournal of Intelligent Systems, 2023
Anti-jamming cyclic frequency feature extraction is an important link in identifying communication interference signals, which is of great significance for eliminating electronic communication interference factors and improving the security of electronic
Yang Xuemei
doaj   +1 more source

Gene Dosage Analysis on the Single-Cell Transcriptomes Linking Cotranslational Protein Targeting to Metastatic Triple-Negative Breast Cancer

open access: yesPharmaceuticals, 2021
Many recent efforts have been put into the association between expression heterogeneity and different cell types and states using single-cell RNA transcriptome analysis.
Yining Liu, Min Zhao
doaj   +1 more source

Site-Specific Fluorescent Labeling of Nascent Proteins on the Translating Ribosome [PDF]

open access: yes, 2011
As newly synthesized proteins emerge from the ribosome, they interact with a variety of cotranslational cellular machineries that facilitate their proper folding, maturation, and localization.
Chandrasekaran, Sandhya   +3 more
core   +1 more source

Deep-learned Top Tagging with a Lorentz Layer

open access: yes, 2018
We introduce a new and highly efficient tagger for hadronically decaying top quarks, based on a deep neural network working with Lorentz vectors and the Minkowski metric.
Butter, Anja   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Identification of Gastroenteric Viruses by Electron Microscopy Using Higher Order Spectral Features [PDF]

open access: yes, 2005
Background: Many paediatric illnesses are caused by viral agents, for example, acute gastroenteritis. Electron microscopy can provide images of viral particles and can be used to identify the agents.
Chandran, Vinod, Ong, Chien
core   +2 more sources

GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor. [PDF]

open access: yesThe Journal of cell biology, 1993
Translocation of proteins across the endoplasmic reticulum membrane is a GTP-dependent process. The signal recognition particle (SRP) and the SRP receptor both contain subunits with GTP binding domains. One GTP-dependent reaction during protein translocation is the SRP receptor-mediated dissociation of SRP from the signal sequence of a nascent ...
Connolly, Timothy, Gilmore, Reid
openaire   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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