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AFM observation of protein translocation mediated by one unit of SecYEG-SecA complex. [PDF]

open access: yesNat Commun
Protein translocation across cellular membranes is an essential and nano-scale dynamic process. In the bacterial cytoplasmic membrane, the core proteins in this process are a membrane protein complex, SecYEG, corresponding to the eukaryotic Sec61 complex,
Kanaoka Y   +11 more
europepmc   +2 more sources

SecA inhibitors as potential antimicrobial agents: differential actions on SecA-only and SecA-SecYEG protein-conducting channels

open access: yesFEMS Microbiology Letters, 2018
Sec-dependent protein translocation is an essential process in bacteria. SecA is a key component of the translocation machinery and has multiple domains that interact with various ligands.
Sen-Fang Sui, Binghe Wang, Phang C Tai
exaly   +2 more sources

Structural basis of SecA-mediated protein translocation

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2023
Significance The vast majority of secretory proteins in bacteria are translocated across the cell membranes through the SecY channel by a highly conserved ATPase, SecA.
Linlin Dong   +6 more
semanticscholar   +1 more source

Ribosome profiling reveals multiple roles of SecA in cotranslational protein export

open access: yesNature Communications, 2022
SecA, an ATPase known to posttranslationally translocate secretory proteins across the bacterial plasma membrane, also binds ribosomes, but the role of SecA’s ribosome interaction has been unclear.
Zikun Zhu, Shuai Wang, S. Shan
semanticscholar   +1 more source

Comparison of the Sub-Tour Elimination Methods for the Asymmetric Traveling Salesman Problem Applying the SECA Method

open access: yesAxioms, 2021
There are many sub-tour elimination constraint (SEC) formulations for the traveling salesman problem (TSP). Among the different methods found in articles, usually three apply more than others.
Ramin Bazrafshan   +2 more
semanticscholar   +1 more source

Cellular dynamics of the SecA ATPase at the single molecule level

open access: yesScientific Reports, 2021
In bacteria, the SecA ATPase provides the driving force for protein secretion via the SecYEG translocon. While the dynamic interplay between SecA and SecYEG in translocation is widely appreciated, it is not clear how SecA associates with the translocon ...
Anne-Bart Seinen   +3 more
semanticscholar   +1 more source

Growth of Rescues in Natural Areas during the First Summer of COVID-19 Pandemic in Catalonia

open access: yesLand, 2021
This article analyzes the impact of the end of the COVID-19 lockdown on the number of rescues in natural areas in Catalonia (Spain) during July and August 2020.
Òscar Saladié   +2 more
doaj   +1 more source

Eficiência agronômica e qualidade sanitária de biofertilizantes aplicados no solo em cultivo orgânico da alface

open access: yesRevista Verde de Agroecologia e Desenvolvimento Sustentável, 2020
A adubação de hortaliças por meio de biofertilizantes é utilizada principalmente pela agricultura orgânica. No entanto, são escassos os trabalhos publicados avaliando a microbiota potencialmente patogênica a humanos nos biofertilizantes, assim como sua ...
Álisson Queiroz Moura   +5 more
doaj   +1 more source

Identifying the Socio-Spatial Logics of Foreclosed Housing Accumulated by Large Private Landlords in Post-Crisis Catalan Cities

open access: yesISPRS International Journal of Geo-Information, 2020
The article analyses the socio-spatial logic behind the accumulation of foreclosed housing in the hands of large private landlords in the neighbourhoods of all the Catalan cities with over 100,000 inhabitants. Spatial regression and clustering techniques
Aaron Gutiérrez, Antoni Domènech
doaj   +1 more source

Liver transplantation for unresectable colorectal liver metastases in patients and donors with extended criteria (SECA‐II arm D study)

open access: yesBJS Open, 2020
Patients with metastatic colorectal cancer receiving palliative chemotherapy have a 5‐year survival rate of approximately 10 per cent. Liver transplantation using strict selection criteria in patients with colorectal cancer and unresectable liver‐only ...
T. M. Smedman   +5 more
semanticscholar   +1 more source

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