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Genetic Analysis of Protein Translocation. [PDF]
Protein J, 2019 Cells in all domains of life must translocate newly synthesized proteins both across membranes and into membranes. In eukaryotes, proteins are translocated into the lumen of the ER or the ER membrane. In prokaryotes, proteins are translocated into the cytoplasmic membrane or through the membrane into the periplasm for Gram-negative bacteria or the ...
Silhavy TJ, Mitchell AM.
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The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans [PDF]
mBio, 2023 The fungal pathogen Cryptococcus neoformans is distinguished by a cell-wall-anchored polysaccharide capsule that is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway.
Felipe H. Santiago-Tirado +6 more
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Protein Translocation Control in E. coli via Temperature-Dependent Aggregation: Application to a Conditionally Lethal Enzyme, Levansucrase [PDF]
BiomoleculesPrecise control of protein translocation is essential for synthetic biology and protein engineering. Here, we present a temperature-responsive system using elastin-like polypeptides (ELPs) to regulate the translocation of a conditionally lethal enzyme in
Young Kee Chae
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How Quality Control Systems AID Sec-Dependent Protein Translocation [PDF]
Frontiers in Molecular Biosciences, 2021 The evolutionarily conserved Sec machinery is responsible for transporting proteins across the cytoplasmic membrane. Protein substrates of the Sec machinery must be in an unfolded conformation in order to be translocated across (or inserted into) the ...
Chen Jiang, Max Wynne, Damon Huber
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Clearing Traffic Jams During Protein Translocation Across Membranes [PDF]
Frontiers in Cell and Developmental Biology, 2021 Protein translocation across membranes is a critical facet of protein biogenesis in compartmentalized cells as proteins synthesized in the cytoplasm often need to traverse across lipid bilayers via proteinaceous channels to reach their final destinations.
Lihui Wang, Yihong Ye
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Central role of Tim17 in mitochondrial presequence protein translocation [PDF]
Nature, 2023 Hans-Georg Koch +2 more
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The Translocator Protein [PDF]
Journal of Nuclear Medicine, 2011 The translocator protein (TSPO) is expressed at low levels in the healthy human brain and is markedly upregulated in response to brain injury and inflammation. This increase in TSPO expression is correlated to the extent of microglial activation, making the measurement of TSPO density a useful indicator of active brain disease.
Alana M, Scarf, Michael, Kassiou
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Frontiers in Microbiology, 2022 Most motile bacteria utilize the flagellar type III secretion system (fT3SS) to construct the flagellum, which is a supramolecular motility machine consisting of basal body rings and an axial structure.
Tohru Minamino +4 more
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Understanding protein import in diverse non-green plastids
Frontiers in Genetics, 2023 The spectacular diversity of plastids in non-green organs such as flowers, fruits, roots, tubers, and senescing leaves represents a Universe of metabolic processes in higher plants that remain to be completely characterized.
Ryan Christian +5 more
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Translocator protein and steroidogenesis [PDF]
Biochemical Journal, 2018 Two interesting papers by Barren et al. and Owen et al. have been very recently published in Biochemical Journal, reporting the role of translocator protein (TSPO) in steroidogenesis. The involvement of TSPO in the steroid biosynthesis has been suggested by 30 years of researches, using biochemical, pharmacological and genetic experimental approaches ...
Costa, Barbara +2 more
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