Results 31 to 40 of about 3,931,468 (303)
A functional link between the co-translational protein translocation pathway and the UPR
eLife, 2015 Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is unclear how the low abundant Ire1α efficiently finds and cleaves the majority of mRNAs at the ER ...
Rachel Plumb +3 more
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FEBS Open Bio, 2020 Many nascent polypeptides synthesized in the cytoplasm are translocated across membranes via a specific ‘translocon’ composed of protein complexes. Recently, a novel targeting pathway for the outer membrane β‐barrel proteins (OMPs) in Gram‐negative ...
Feng Jin
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Functional Organization of Sequence Motifs in Diverse Transit Peptides of Chloroplast Proteins
Frontiers in Physiology, 2021 Although the chloroplasts in plants are characterized by an inherent genome, the chloroplast proteome is composed of proteins encoded by not only the chloroplast genome but also the nuclear genome.
Jinseung Jeong +3 more
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Frontiers in Microbiology, 2019 Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage tissue sites, and evade the immune system. One essential strategy of Gram-negative bacteria is the secretion of virulence factors through both inner and outer membranes ...
Fernando Navarro-Garcia +3 more
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Protein Translocation into Mitochondria
Neurosignals, 2001 The biogenesis of mitochondria requires the translocation of most mitochondrial proteins across two biological membranes. Mitochondrial preproteins are synthesized in the cytosol carrying targeting information, that is recognized by specific receptor proteins.
Schmidt, Sigune +2 more
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Membrane translocation of folded proteins
Journal of Biological Chemistry, 2022 An ever-increasing number of proteins have been shown to translocate across various membranes of bacterial as well as eukaryotic cells in their folded states as a part of physiological and/or pathophysiological processes. Herein, we provide an overview of the systems/processes that are established or likely to involve the membrane translocation of ...
Pei, Dehua, Dalbey, Ross E.
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YidC from Escherichia coli Forms an Ion-Conducting Pore upon Activation by Ribosomes
Biomolecules, 2023 The universally conserved protein YidC aids in the insertion and folding of transmembrane polypeptides. Supposedly, a charged arginine faces its hydrophobic lipid core, facilitating polypeptide sliding along YidC’s surface.
Denis G. Knyazev +9 more
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eLife, 2022 Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery.
William J Allen +6 more
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On the translocation of proteins across membranes. [PDF]
Proceedings of the National Academy of Sciences, 1987 Many proteins of intracellular organelles are first synthesized in the cytoplasm and are then specifically transferred across the membranes of the organelles. On the assumption that these transfers all occur by the same basic mechanism, we enumerate the rather stringent requirements that the mechanism must satisfy. A unitary molecular mechanism is then
Singer, S.J., Maher, P.A., Yaffe, M.P.
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Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]
, 1991 Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Soll, Jürgen, Waegemann, Karin
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