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Identification of protein secretion systems and type III effectors in wood-associated bacteria of the genus Xylophilus [PDF]
To gain insights into the biology of bacteria of the genus Xylophilus, including the grapevine pathogen Xylophilus ampelinus, we scrutinized all available genome sequences of the genus for the presence of type III secretion and flagellar systems.
Zoe Roux +4 more
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Evaluation of Unconventional Protein Secretion by Saccharomyces cerevisiae and other Fungi
Development of proteome analysis of extracellular proteins has revealed that a wide variety of proteins, including fungal allergens are present outside the cell. These secreted allergens often do not contain known secretion signal sequences.
Natsuko Miura, Mitsuyoshi Ueda
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The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a contractile outer sheath to inject a rigid spear-like inner tube into target bacterial and eukaryotic cells.
Hao-Yu Zheng, Liang Yang, Tao Dong
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Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane
Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9).
Stefano Bestetti +6 more
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Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi +20 more
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Background Protein secretion in bacteria is an attractive strategy for heterologous protein production because it retains the high titers and tractability of bacterial hosts while simplifying downstream processing.
Lisa Ann Burdette +2 more
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Hepatitis B virus (HBV) expresses co-terminal large (L), middle (M), and small (S) envelope proteins. S protein drives virion and subviral particle secretion, whereas L protein inhibits subviral particle secretion but coordinates virion morphogenesis. We
Jing Zhang +8 more
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Background The budding yeast Komagataella phaffii (Pichia pastoris) is widely employed to secrete proteins of academic and industrial interest.
Chenwei Zou +6 more
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Tannerella forsythia and Porphyromonas gingivalis target distinct virulence factors bearing a structurally conserved C-terminal domain (CTD) to the type IX protein secretion system (T9SS).
Matthias L. Braun +7 more
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The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling
Membranes are of outmost importance to allow for specific signal transduction due to their ability to localize, amplify, and direct signals. However, due to the double-edged nature of reactive oxygen species (ROS)—toxic at high concentrations but ...
Daniela E. Nordzieke +1 more
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