Results 1 to 10 of about 4,543,051 (305)
Autotransporter protein secretion [PDF]
Biomolecular Concepts, 2011 Autotransporter proteins are a large family of virulence factors secreted from Gram-negative bacteria by a unique mechanism. First described in the 1980s, these proteins have a C-terminal region that folds into a β-barrel in the bacterial outer membrane.
Tame Jeremy R.H.
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Regulation of Protein Secretion by … Protein Secretion? [PDF]
Cell Host & Microbe, 2008 Mycobacterium tuberculosis (Mtb) requires an alternative protein secretion system, ESX1, for virulence. Recently, Raghavan et al. (2008) reported a new regulatory circuit that may explain how ESX1 activity is controlled during infection. Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of ...
Atmakuri, Krishnamohan +1 more
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mSystems, 2021 The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a contractile outer sheath to inject a rigid spear-like inner tube into target bacterial and eukaryotic cells.
Hao-Yu Zheng, Liang Yang, Tao Dong
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Protein secretion and secreted proteins in pathogenicNeisseriaceae [PDF]
FEMS Microbiology Reviews, 2006 Secreted proteins of pathogenic bacteria are often essential virulence factors. They are involved, for example, in the adherence of the bacteria to host cells or required to suppress the host's defence mechanisms. Until recently, only IgA1 protease had been studied in detail in the NeisseriaceaeNeisseria meningitidis and Neisseria gonorrhoeae.
van Ulsen, J.P., Tommassen, J.P.M.
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Secreted protein kinases [PDF]
Trends in Biochemical Sciences, 2013 Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci +2 more
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Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane
Redox Biology, 2020 Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9).
Stefano Bestetti +6 more
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Secretin interactions in the type II secretion system [PDF]
, 2012 PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
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EMBO Molecular Medicine, 2020 Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi +20 more
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Viruses, 2021 Hepatitis B virus (HBV) expresses co-terminal large (L), middle (M), and small (S) envelope proteins. S protein drives virion and subviral particle secretion, whereas L protein inhibits subviral particle secretion but coordinates virion morphogenesis. We
Jing Zhang +8 more
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