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A Co-attention Mechanism of Jointly Capturing Sequence and Structure Features for Signal Peptide Prediction [PDF]
Computational and Structural Biotechnology JournalHighlights • Signal-3L 4.0 integrates sequence and structure via a VisualBERT-style co-attention and protein language model.• Class-balanced label-distribution-aware margin loss improves performance on rare signal peptide types.• Signal-3L 4.0 enhances ...
Zhixuan Piao +3 more
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Structural basis of signal peptide recognition by the signal peptidase complex [PDF]
Nature CommunicationsThe signal peptidase complex (SPC) is responsible for cleaving signal peptides (SPs) from approximately 10% of the human proteome. SPs are characterized by a tripartite structure, consisting of an N-terminal n-region, a central helical h-region and a C ...
A. Manuel Liaci +9 more
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Frontiers in Bioengineering and Biotechnology, 2019 Signal peptides are short peptides directing newly synthesized proteins toward the secretory pathway. These N-terminal signal sequences are ubiquitous to all prokaryotes and eukaryotes.
Chong Peng +17 more
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Efficient secretory production of recombinant proteins in microalgae using an exogenous signal peptide [PDF]
Frontiers in MicrobiologyMicroalgae are promising platforms for recombinant protein production due to their scalability, rapid growth, safety, and sustainability. One strategy to reduce downstream processing costs is to secrete recombinant proteins directly into the culture ...
Trang Thi Le +14 more
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Molecules, 2022 The COVID-19 pandemic is caused by SARS-CoV-2; the spike protein is a key structural protein that mediates infection of the host by SARS-CoV-2. In this study, we aimed to evaluate the effects of signal peptide on the secretion and release of SARS-CoV-2 ...
Zhikai Zhang +3 more
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The Journal of Qazvin University of Medical Sciences, 2022 Background: The heparin-binding hemagglutinin (HBHA) protein belonging to Mycobacterium tuberculosis is known as a molecular adjuvant. Objective: Hence, the expression of this protein in the prokaryotic system is essential.
Ali Forouharmehr +4 more
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Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region
Biochemistry and Biophysics Reports, 2022 AA amyloidosis is the result of overproduction and aberrant processing of acute-phase serum amyloid A1 (SAA1) by hepatocytes. Proteolytic cleavage of SAA1 is believed to play a central role in AA amyloid formation.
Morgan S. Haines +3 more
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Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2020 Location of the proteases would affect on protease stability and photorespiratory bypass pathway, while it is unsolved. Potato rbcS signal peptide was analyzed and constructed into the protease for study of their localization site.
Zhen YAO +3 more
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Microbiology Spectrum, 2023 Escherichia coli signal peptidase I (LepB) has been shown to inefficiently cleave secreted proteins with aromatic amino acids at the second position after the signal peptidase cleavage site (P2′).
Joanna E. Musik +8 more
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The PAR2 signal peptide prevents premature receptor cleavage and activation.
PLoS ONE, 2020 Unlike closely related GPCRs, protease-activated receptors (PAR1, PAR2, PAR3, and PAR4) have a predicted signal peptide at their N-terminus, which is encoded by a separate exon, suggesting that the signal peptides of PARs may serve an important and ...
Belinda Liu +10 more
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