Results 31 to 40 of about 4,543,051 (305)

Non-classical protein secretion in bacteria

BMC Microbiology, 2005
Background We present an overview of bacterial non-classical secretion and a prediction method for identification of proteins following signal peptide independent secretion pathways.
Fausbøll Anders, Kiemer Lars, Bendtsen Jannick D, Brunak Søren   +3 more
doaj   +1 more source

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ, Ashford, ML, Smith, Mark A., Al-Qassab, H, Piipari, K, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A, Viollet, Benoit, Ashford, Michael Lj, Viollet, B, Beall, Craig, Smith, MA, Withers, Dominic J, Parker, N, Carling, David, Parker, Nadeene, Withers, Dominic J., Ashford, Michael L. J.; id_orcid, Beall, C, Carling, D   +20 more
core   +1 more source

Analysis of Mycobacterial Protein Secretion

Bio-Protocol, 2014
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Analysis of proteins secreted by Mtb has been of interest to the field of tuberculosis research since certain secreted proteins interact with the host to promote virulence, while ...
Alka Mehra, Jennifer Philips
doaj   +1 more source

Functional analysis of the short splicing variant encoded by CHI3L1/YKL-40 in glioblastoma

Frontiers in Oncology, 2022
The glycoprotein YKL-40 has been well studied as a serum biomarker of prognosis and disease status in glioblastoma. YKL-40 is a chitinase-like protein with defective chitinase activity that plays an important role in promoting cell proliferation ...
Mengqi Shi, Qianyun Ge, Xinrong Wang, Wenbin Diao, Ben Yang, Sipeng Sun, Guohui Wang, Tian Liu, Andrew Man-Lok Chan, Zhiqin Gao, Yi Wang, Yubing Wang   +11 more
doaj   +1 more source

Large-scale production of a thermostable Rhodothermus marinus cellulase by heterologous secretion from Streptomyces lividans

Microbial Cell Factories, 2017
Background The gene encoding a thermostable cellulase of family 12 was previously isolated from a Rhodothermus marinus through functional screening. CelA is a protein of 260 aminoacyl residues with a 28-residue amino-terminal signal peptide.
Mohamed Belal Hamed, Spyridoula Karamanou, Solveig Ólafsdottir, Joana Sofia Martins Basílio, Kenneth Simoens, Kostantinos C. Tsolis, Lieve Van Mellaert, Eik Elísabet Guðmundsdóttir, Gudmundur Oli Hreggvidsson, Jozef Anné, Kristel Bernaerts, Olafur H. Fridjonsson, Anastassios Economou   +12 more
doaj   +1 more source

Monitoring Protein Secretion in Streptomyces Using Fluorescent Proteins

Frontiers in Microbiology, 2018
Fluorescent proteins are a major cell biology tool to analyze protein sub-cellular topology. Here we have applied this technology to study protein secretion in the Gram-positive bacterium Streptomyces lividans TK24, a widely used host for heterologous ...
Mohamed Belal Hamed, Mohamed Belal Hamed, Kristof Vrancken, Bohdan Bilyk, Joachim Koepff, Renata Novakova, Lieve van Mellaert, Marco Oldiges, Andriy Luzhetskyy, Jan Kormanec, Jozef Anné, Spyridoula Karamanou, Anastassios Economou   +12 more
doaj   +1 more source

Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion

eLife, 2022
Transport of proteins across and into membranes is a fundamental biological process with the vast majority being conducted by the ubiquitous Sec machinery.
William J Allen, Robin A Corey, Daniel W Watkins, A Sofia F Oliveira, Kiel Hards, Gregory M Cook, Ian Collinson   +6 more
doaj   +1 more source

Protein Secretion in Spirochetes [PDF]

Microbiology Spectrum, 2019
ABSTRACT Spirochetes form a separate phylum of bacteria with two membranes but otherwise unusual morphologies and envelope structures. Distinctive common features of Borrelia , Leptospira , and Treponema include the sequestration of flagella to the periplasm ...
openaire   +2 more sources

Regulated Secretion: Helper proteins for neuroendocrine secretion [PDF]

Current Biology, 1995
The granins, known to be general constituents of neuroendocrine secretory granules, are regulators of the proteolytic processing of peptide precursors and promote their aggregation-mediated sorting into secretory granules.
Huttner, Wieland B., Natori, Shoichi
openaire   +2 more sources

Mutants of Xanthomonas oryzae pv. oryzae Deficient in General Secretory Pathway Are Virulence Deficient and Unable to Secrete Xylanase

Molecular Plant-Microbe Interactions, 2000
Xanthomonas oryzae pv. oryzae (Xoo) causes bacterial leaf blight, a serious disease of rice. A virulence- and xylanase-deficient mutant of Xoo was isolated following ethyl methane sulfonate (EMS) mutagenesis.
Suvendra K. Ray, R. Rajeshwari, Ramesh V. Sonti   +2 more
doaj   +1 more source