Results 41 to 50 of about 4,543,051 (305)

Identification of 2-Amino Benzothiazoles with Bactericidal Activity against Mycobacterium tuberculosis

Microbiology Spectrum, 2023
We identified an amino-benzothiazole scaffold from a whole-cell screen against recombinant Mycobacterium tuberculosis under expressing the essential signal peptidase LepB. The seed molecule had 2-fold higher activity against the LepB hypomorph. Through a
Shilah Bonnett, Jo-Ann Jee, Somsundaram Chettiar, Yulia Ovechkina, Aaron Korkegian, Eric Greve, Joshua Odingo, Tanya Parish   +7 more
doaj   +1 more source

Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains [PDF]

, 2014
The Type VII protein secretion system, found in Gram-positive bacteria, secretes small proteins, containing a conserved W-x-G amino acid sequence motif, to the growth medium.
Chalmers, James, Jäger, Franziska, van der Kooi - Pol, Magda, Cargill, James S, Cao, Zhen Ping, van der Kooi-Pol, Magdalena M., Hunter, William N., Palmer, Tracy, Ryan, Robert P., Kneuper, Holger, Twomey, Kate B., Ryan, Robert P, Zoltner, Martin, Twomey, Kate B, Cargill, James S., van Dijl, Jan Maarten, Hunter, William N   +16 more
core   +2 more sources

Efficient Secretion and Recombinant Production of a Lactobacillal α-amylase in Lactiplantibacillus plantarum WCFS1: Analysis and Comparison of the Secretion Using Different Signal Peptides

Frontiers in Microbiology, 2021
Lactic acid bacteria (LAB) have been used as starter cultures and producers of enzymes, antimicrobial peptides or metabolites that contribute to the flavor, texture and safety of food products.
Anh-Minh Tran, Anh-Minh Tran, Kridsada Unban, Apinun Kanpiengjai, Apinun Kanpiengjai, Chartchai Khanongnuch, Geir Mathiesen, Dietmar Haltrich, Thu-Ha Nguyen   +8 more
doaj   +1 more source

snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification [PDF]

Cell
Yuhao Zhong
exaly   +2 more sources

Exocytosis and protein secretion in Trypanosoma [PDF]

BMC Microbiology, 2010
Human African trypanosomiasis is a lethal disease caused by the extracellular parasite Trypanosoma brucei. The proteins secreted by T. brucei inhibit the maturation of dendritic cells and their ability to induce lymphocytic allogenic responses. To better understand the pathogenic process, we combined different approaches to characterize these secreted ...
Geiger, Anne, Hirtz, Christophe, Becue, Thierry, Bellard, Eric, Centeno, Delphine, Gargani, Daniel, Rossignol, Michel, Cuny, Gérard, Peltier, Jean-Benoît   +8 more
openaire   +8 more sources

High-Level Production of Bacteriotoxic Phospholipase A1 in Bacterial Host Pseudomonas fluorescens via ABC Transporter-Mediated Secretion and Inducible Expression

Microorganisms, 2020
Bacterial phospholipase A1 (PLA1) is used in various industrial fields because it can catalyze the hydrolysis, esterification, and transesterification of phospholipids to their functional derivatives.
Jiyeon Park, Gyeong Tae Eom, Joon Young Oh, Ji Hyun Park, Sun Chang Kim, Jae Kwang Song, Jung Hoon Ahn   +6 more
doaj   +1 more source

Calmodulin antagonists stimulate renin secretion and inhibit renin synthesis in vitro [PDF]

, 1992
To find out whether calmodulin activity could be a common denominator for the cellular control of renin secretion and synthesis, we have examined the effects of calmodulin antagonists on the secretion and the synthesis of renin in primary cultures of ...
Kurtz, Armin, Della Bruna, R., R. Della Bruna, Corvol, P., A. Kurtz, F. Pinet, P. Corvol, Pinet, F.   +7 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex [PDF]

, 2013
The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia.
Guowei Yang, Yang Guowei, Yang, Guowei, Guowei Yang (163967), Waterfield, Nicholas R., Nicholas R. Waterfield (163985), Nicholas R Waterfield, Waterfield Nicholas R.   +7 more
core   +1 more source

Lipoprotein assembly capacity of the mammary tumor-derived cell line C127 is due to the expression of functional microsomal triglyceride transfer protein

Journal of Lipid Research, 2001
C127, a murine mammary tumor-derived cell line, is capable of lipidating and secreting apolipoprotein B-41 (apoB-41) in the apparent absence of microsomal triglyceride transfer protein (MTP).
Jeremy A. Sellers, Gregory S. Shelness
doaj   +1 more source