Results 61 to 70 of about 4,543,051 (305)
Frontiers in Endocrinology, 2018 O-linked β-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation of O-GlcNAcylation occurs in a wide range of diseases, including cancer, diabetes, and ...
Nathan J. Cox +5 more
doaj +1 more source
Dual Targeting Factors Are Required for LXG Toxin Export by the Bacterial Type VIIb Secretion System
mBio, 2022 Bacterial type VIIb secretion systems (T7SSb) are multisubunit integral membrane protein complexes found in Firmicutes that play a role in both bacterial competition and virulence by secreting toxic effector proteins.
Timothy A. Klein +7 more
doaj +1 more source
The Secrets of Secretion: Protein Transport in Cells
Frontiers for Young Minds, 2023 Secretion is a fundamental process in which cells release substances to their external environments. Secretion is essential for many body functions, including growth, digestion, and cell communication. To be secreted, proteins must pass through various stations inside cells, which together form what is called the secretory pathway.
openaire +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
The central metabolism regulator EIIAGlc switches Salmonella from growth arrest to acute virulence through activation of virulence factor secretion [PDF]
, 2014 The ability of Salmonella to cause disease depends on metabolic activities and virulence factors. Here, we show that a key metabolic protein, EIIAGlc, is absolutely essential for acute infection, but not for Salmonella survival, in a mouse typhoid fever ...
Timo Glatter +11 more
core +1 more source
Structural Basis of the Subcellular Topology Landscape of Escherichia coli
Frontiers in Microbiology, 2019 Cellular proteomes are distributed in multiple compartments: on DNA, ribosomes, on and inside membranes, or they become secreted. Structural properties that allow polypeptides to occupy subcellular niches, particularly to after crossing membranes, remain
Maria S. Loos +17 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Tannerella forsythia and Porphyromonas gingivalis target distinct virulence factors bearing a structurally conserved C-terminal domain (CTD) to the type IX protein secretion system (T9SS).
Matthias L. Braun +7 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. [PDF]
, 2009 Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer.
Haas, Rainer +42 more
core +2 more sources
Frontiers in Plant Science, 2015 The steadily increasing number of sequenced fungal and oomycete genomes has enabled detailed studies of how these eukaryotic microbes infect plants and cause devastating losses in food crops.
Jana eSperschneider +7 more
doaj +1 more source