Results 11 to 20 of about 4,543,051 (305)

Post-Transcriptional Control of mRNA Metabolism and Protein Secretion: The Third Level of Regulation within the NF-κB System

Biomedicines, 2022
The NF-κB system is a key transcriptional pathway that regulates innate and adaptive immunity because it triggers the activation and differentiation processes of lymphocytes and myeloid cells during immune responses.
Jasmin Priester, Jan Dreute, Michael Kracht, M. Lienhard Schmitz   +3 more
doaj   +1 more source

Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum Bacteroidetes

mBio, 2022
Gliding motility using cell surface adhesins, and export of proteins by the type IX secretion system (T9SS) are two phylum-specific features of the Bacteroidetes.
Rory Hennell James, Justin C. Deme, Alicia Hunter, Ben C. Berks, Susan M. Lea   +4 more
doaj   +1 more source

Type VI secretion: a beginner's guide [PDF]

, 2008
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Bailey, Christopher, Bailey, Christopher M., Bingle, Lewis E. H., Bailey, Christopher M, Pallen, Mark J, Pallen, Mark J., Bingle, Lewis, Pallen, Mark   +7 more
core   +1 more source

An optimized growth medium for increased recombinant protein secretion titer via the type III secretion system

Microbial Cell Factories, 2021
Background Protein secretion in bacteria is an attractive strategy for heterologous protein production because it retains the high titers and tractability of bacterial hosts while simplifying downstream processing.
Lisa Ann Burdette, Han Teng Wong, Danielle Tullman-Ercek   +2 more
doaj   +1 more source

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens [PDF]

, 2014
Pathogenic bacteria adapt to their environment and manipulate the biochemistry of hosts by secretion of effector molecules. Serratia marcescens is an opportunistic pathogen associated with healthcare-acquired infections and is a prolific secretor of ...
Guo, Manman, Sargent, Frank, Sarah J. Coulthurst, Buchanan, Grant, Stanley-Wall, Nicola R.; id_orcid, Nicola R. Stanley-Wall, Owen, Richard A., Trost, Matthias, Govind Chandra, Coulthurst, Sarah J.; id_orcid, Matthias Trost, Tracy Palmer, Costa, Marília de Assis Alcoforado, Victoria L. Marlow, Richard A. Owen, Palmer, Tracy, Jaeger J. Hamilton, Hamilton, Jaeger J., Manman Guo, Marlow, Victoria L., Grant Buchanan, Chandra, Govind, Marília de Assis Alcoforado Costa, Frank Sargent   +23 more
core   +1 more source

The Plasma Membrane: A Platform for Intra- and Intercellular Redox Signaling

Antioxidants, 2018
Membranes are of outmost importance to allow for specific signal transduction due to their ability to localize, amplify, and direct signals. However, due to the double-edged nature of reactive oxygen species (ROS)—toxic at high concentrations but ...
Daniela E. Nordzieke, Iria Medraño-Fernandez   +1 more
doaj   +1 more source

Environmental salinity determines the specificity and need for tat-dependent secretion of the YwbN protein in bacillus subtilis [PDF]

, 2011
Twin-arginine protein translocation (Tat) pathways are required for transport of folded proteins across bacterial, archaeal and chloroplast membranes. Recent studies indicate that Tat has evolved into a mainstream pathway for protein secretion in certain
Miethke, Marcus, Theresa Winter, Schaffer Marc, van der Ploeg, René, Jan Maarten van Dijl, Harwood, Colin R., Denham, Emma, Monteferrante, Carmine G., Ulrike Mäder, Marcus Miethke, Maeder, Ulrike, van der Ploeg René, René van der Ploeg, Mohamed A Marahiel, Denham, Emma L., Harwood Colin R., Colin R. Harwood, van Dijl, Jan Maarten, Homuth, Georg, Hecker Michael, Monteferrante Carmine G., Carmine G Monteferrante, Georg Homuth, Mäder Ulrike, Mäder, Ulrike, van Dijl Jan Maarten, Winter Theresa, Emma L. Denham, Homuth Georg, Miethke Marcus, Schaffer, Marc, Michael Hecker, Marahiel Mohamed A., Hecker, Michael, Dijl, Jan Maarten van, Winter, Theresa, Haike Antelmann, Marahiel, Mohamed A., Antelmann, Haike, Antelmann Haike, Carmine G. Monteferrante, Emma L Denham, Denham Emma L., Colin R Harwood, Marc Schaffer, Mohamed A. Marahiel   +45 more
core   +2 more sources

Developing Gram-negative bacteria for the secretion of heterologous proteins

Microbial Cell Factories, 2018
Gram-negative bacteria are attractive hosts for recombinant protein production because they are fast growing, easy to manipulate, and genetically stable in large cultures. However, the utility of these microbes would expand if they also could secrete the
Lisa Ann Burdette, Samuel Alexander Leach, Han Teng Wong, Danielle Tullman-Ercek   +3 more
doaj   +1 more source

Structural analysis of Salmonella enterica effector protein SopD [PDF]

, 2004
Salmonella outer protein D (SopD) is a type III secreted virulence effector protein from Salmonella enterica. Full-length SopD and SopD lacking 16 amino acids at the N-terminus (SopDDeltaN) have been expressed as fusions with GST in Escherichia coli ...
Williams, C, Gill, A C, Galyov, E E, van den Elsen, J M H, Upadhyay, A, Bagby, S, Wood, M W, Philippe, D L   +7 more
core   +1 more source

Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A. [PDF]

, 2012
nefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production.
Tonn, Torsten, Milanov, Peter, Schüttrumpf, Jörg, Seifried, Erhard, Patricia Quade-Lyssy, Quade-Lyssy, Patricia, Jörg Schüttrumpf, Roth, Stefanie D., Simpson, Jeremy C., Christopher Ungerer, Erhard Seifried, Abriss, Daniela, Pepperkok, Rainer, Rainer Pepperkok, Stefanie D Roth, Jeremy C Simpson, Torsten Tonn, Ungerer, Christopher, Peter Milanov, Daniela Abriss   +19 more
core   +1 more source