Results 11 to 20 of about 5,630,720 (303)

Autotransporter protein secretion [PDF]

Biomolecular Concepts, 2011
Autotransporter proteins are a large family of virulence factors secreted from Gram-negative bacteria by a unique mechanism. First described in the 1980s, these proteins have a C-terminal region that folds into a β-barrel in the bacterial outer membrane.
Tame Jeremy R.H.
doaj   +3 more sources

Regulation of Protein Secretion by … Protein Secretion? [PDF]

Cell Host & Microbe, 2008
Mycobacterium tuberculosis (Mtb) requires an alternative protein secretion system, ESX1, for virulence. Recently, Raghavan et al. (2008) reported a new regulatory circuit that may explain how ESX1 activity is controlled during infection. Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of ...
Atmakuri, Krishnamohan, Fortune, Sarah M.   +1 more
openaire   +2 more sources

Protein secretion and secreted proteins in pathogenicNeisseriaceae [PDF]

FEMS Microbiology Reviews, 2006
Secreted proteins of pathogenic bacteria are often essential virulence factors. They are involved, for example, in the adherence of the bacteria to host cells or required to suppress the host's defence mechanisms. Until recently, only IgA1 protease had been studied in detail in the NeisseriaceaeNeisseria meningitidis and Neisseria gonorrhoeae.
van Ulsen, J.P., Tommassen, J.P.M.
openaire   +3 more sources

Secreted protein kinases [PDF]

Trends in Biochemical Sciences, 2013
Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci, PINNA, LORENZO, Jack E. Dixon   +2 more
openaire   +3 more sources

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2013
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K., Guix Arnau, Susana, Katayama, K., Crawford, Sue E., Sharp, T. M.   +4 more
core   +3 more sources

Type VI secretion: a beginner's guide [PDF]

, 2008
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Bailey, Christopher, Bailey, Christopher M., Bingle, Lewis E. H., Bailey, Christopher M, Pallen, Mark J, Pallen, Mark J., Bingle, Lewis, Pallen, Mark   +7 more
core   +1 more source

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens [PDF]

, 2014
Pathogenic bacteria adapt to their environment and manipulate the biochemistry of hosts by secretion of effector molecules. Serratia marcescens is an opportunistic pathogen associated with healthcare-acquired infections and is a prolific secretor of ...
Guo, Manman, Sargent, Frank, Sarah J. Coulthurst, Buchanan, Grant, Stanley-Wall, Nicola R.; id_orcid, Nicola R. Stanley-Wall, Owen, Richard A., Trost, Matthias, Govind Chandra, Coulthurst, Sarah J.; id_orcid, Matthias Trost, Tracy Palmer, Costa, Marília de Assis Alcoforado, Victoria L. Marlow, Richard A. Owen, Palmer, Tracy, Jaeger J. Hamilton, Hamilton, Jaeger J., Manman Guo, Marlow, Victoria L., Grant Buchanan, Chandra, Govind, Marília de Assis Alcoforado Costa, Frank Sargent   +23 more
core   +1 more source

Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A. [PDF]

, 2012
nefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production.
Tonn, Torsten, Milanov, Peter, Schüttrumpf, Jörg, Seifried, Erhard, Patricia Quade-Lyssy, Quade-Lyssy, Patricia, Jörg Schüttrumpf, Roth, Stefanie D., Simpson, Jeremy C., Christopher Ungerer, Erhard Seifried, Abriss, Daniela, Pepperkok, Rainer, Rainer Pepperkok, Stefanie D Roth, Jeremy C Simpson, Torsten Tonn, Ungerer, Christopher, Peter Milanov, Daniela Abriss, Ungerer Christopher, Seifried Erhard, Abriss Daniela, Simpson Jeremy C., Quade-Lyssy Patricia, Milanov Peter, Schüttrumpf Jörg, Roth Stefanie D., Pepperkok Rainer, Tonn Torsten   +29 more
core   +1 more source

Structural analysis of Salmonella enterica effector protein SopD [PDF]

, 2004
Salmonella outer protein D (SopD) is a type III secreted virulence effector protein from Salmonella enterica. Full-length SopD and SopD lacking 16 amino acids at the N-terminus (SopDDeltaN) have been expressed as fusions with GST in Escherichia coli ...
Williams, C, Gill, A C, Galyov, E E, van den Elsen, J M H, Upadhyay, A, Bagby, S, Wood, M W, Philippe, D L, Michael W. Wood, Abhishek Upadhyay, Didier L. Philippe, Christopher Williams, Andrew C. Gill, Stefan Bagby, Edouard E. Galyov, Jean M.H. van den Elsen   +15 more
core   +1 more source

Secretin interactions in the type II secretion system [PDF]

, 2012
PhDThe type II secretion system (T2SS) is the major terminal branch of the general secretory pathway. It is composed of 12-15 proteins, most in multiple copies, and spans the inner and outer membranes of Gram-negative bacteria.
Gu, Shuang
core   +4 more sources