Results 11 to 20 of about 3,931,468 (303)

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Tropschug, Maximilian, Pfanner, Nikolaus, Becker, Karin, Schleyer, Manfred, Neupert, Walter, Horwich, Arthur, Guiard, Bernard, Wienhues, Ulla   +7 more
core   +2 more sources

Structural basis of substrate recognition by a polypeptide processing and secretion transporter

eLife, 2020
The peptidase-containing ATP-binding cassette transporters (PCATs) are unique members of the ABC transporter family that proteolytically process and export peptides and proteins.
Virapat Kieuvongngam, Paul Dominic B Olinares, Anthony Palillo, Michael L Oldham, Brian T Chait, Jue Chen   +5 more
doaj   +1 more source

Signal Peptide Features Determining the Substrate Specificities of Targeting and Translocation Components in Human ER Protein Import

Frontiers in Physiology, 2022
In human cells, approximately 30% of all polypeptides enter the secretory pathway at the level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal signal peptides (SPs) or more or less amino-terminal transmembrane helices ...
Sven Lang, Duy Nguyen, Pratiti Bhadra, Martin Jung, Volkhard Helms, Richard Zimmermann   +5 more
doaj   +1 more source

Protein Translocation Acquires Substrate Selectivity Through ER Stress-Induced Reassembly of Translocon Auxiliary Components

Cells, 2020
Protein import across the endoplasmic reticulum membrane is physiologically regulated in a substrate-selective manner to ensure the protection of stressed ER from the overload of misfolded proteins. However, it is poorly understood how different types of
Sohee Lee, Yejin Shin, Kyunggon Kim, Youngsup Song, Yongsub Kim, Sang-Wook Kang   +5 more
doaj   +1 more source

Lost in translocation: the functions of the 18-kD translocator protein [PDF]

Trends in Endocrinology & Metabolism, 2015
Research spanning nearly four decades has assigned to the translocator protein (18 kDa) (TSPO) a critical role, among others, in the mitochondrial import of cholesterol, the subsequent steps of (neuro)steroid production, and systemic endocrine regulation, with implications for the pathophysiology of immune, inflammatory, neurodegenerative, and ...
Gut, P, Zweckstetter, M, Banati, RB
openaire   +6 more sources

Protein translocation across mitochondrial membranes [PDF]

, 1992
Protein translocation across biological membranes is of fundamental importance for the biogenesis of organelles and in protein secretion. We will give an overview of the recent achievements in the understanding of protein translocation across ...
Walter Neupert, Ulla Wienhues, Neupert, Walter, Wienhues, Ulla   +3 more
core   +1 more source

Translocation and insertion of precursor proteins into isolated outer membranes of mitochondria [PDF]

, 1993
Nuclear-encoded proteins destined for mitochondria must cross the outer or both outer and inner membranes to reach their final sub- mitochondrial locations. While the inner membrane can translocate preproteins by itself, it is not known whether the outer
W Neupert, Lill, Roland, Neupert, Walter, A Mayer, Mayer, Andreas, R Lill   +5 more
core   +2 more sources

Crosstalk between the chloroplast protein import and SUMO systems revealed through genetic and molecular investigation in Arabidopsis

eLife, 2021
The chloroplast proteome contains thousands of different proteins that are encoded by the nuclear genome. These proteins are imported into the chloroplast via the action of the TOC translocase and associated downstream systems.
Samuel James Watson, Na Li, Yiting Ye, Feijie Wu, Qihua Ling, R Paul Jarvis   +5 more
doaj   +1 more source

Proton Translocation in Proteins

Annual Review of Physical Chemistry, 1989
The active transport of protons across the low dielectric barrier imposed by biological membranes is accomplished by a plethora of proteins that span the ca. 40 A of the phospholipid bilayer. The free energy derived from the proton electrochemical potential established by the translocation of these protons can subsequently be used to drive vital ...
Copeland, Robert A., Chan, Sunney I.
openaire   +3 more sources

Mechanisms of CFTR folding at the endoplasmic reticulum

Frontiers in Pharmacology, 2012
In the past decade much has been learned about how CFTR folds and misfolds as the etiologic cause of cystic fibrosis (CF). CFTR folding is complex and hierarchical, takes place in multiple cellular compartments and physical environments, and involves ...
Soo Jung Kim, William R Skach
doaj   +1 more source