Results 31 to 40 of about 1,305,355 (298)
N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth
Redox Biology, 2022 Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular carcinoma (HCC) remains undefined. We explored the functional effects of MerTK and
Yongzhang Liu +13 more
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Cell & Bioscience, 2022 Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer +16 more
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Molecular Oncology, 2022 Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia +14 more
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The Ribosome as a Hub for Protein Quality Control [PDF]
Molecular Cell, 2013 Cells face a constant challenge as they produce new proteins. The newly synthesized polypeptides must be folded properly to avoid aggregation. If proteins do misfold, they must be cleared to maintain a functional and healthy proteome. Recent work is revealing the complex mechanisms that work cotranslationally to ensure protein quality control during ...
Pechmann, Sebastian +2 more
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Charactering the spoilage mechanism of “three sticks” of Jinhua ham
Food Science and Human Wellness, 2022 To investigate the spoilage characteristics of Jinhua ham, sensory scores, volatile compounds, biogenic amine, physicochemical parameters and microbial counts were evaluated between normal and spoiled hams.
Changyu Zhou +6 more
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Protein Folding and Quality Control in the ER [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER quality control (ERQC) system. The ERQC facilitates folding and modification of secretory and membrane proteins and eliminates terminally misfolded polypeptides through ER-associated degradation (ERAD) or autophagic degradation.
Kazutaka, Araki, Kazuhiro, Nagata
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Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core +1 more source
Ribosome-associated protein quality control [PDF]
Nature Structural & Molecular Biology, 2016 Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA, insufficient availability of charged tRNAs and genetic errors. All organisms have evolved mechanisms to recognize stalled ribosomes and initiate pathways for recycling, quality control and stress signaling. Here we review the discovery and molecular dissection of the
Onn, Brandman, Ramanujan S, Hegde
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionDental caries is one of the most common and costly biofilm-dependent oral diseases in the world. Streptococcus mutans is the major cariogenic pathogen of dental caries. S.
Shuwei Liu +10 more
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Quality control of overexpressed membrane proteins [PDF]
Proceedings of the National Academy of Sciences, 2008 Overexpression of membrane proteins in Escherichia coli frequently leads to the formation of aggregates or inclusion bodies, which is undesirable for most studies. Ideally, one would like to optimize the expression conditions by monitoring simultaneously and rapidly both the amounts of ...
Geertsma, Eric R. +3 more
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