Results 21 to 30 of about 22,982,554 (304)
Protein quality control at the Golgi.
Current Opinion in Cell Biology, 2022 The majority of the proteome in eukaryotic cells is targeted to organelles. To maintain protein homeostasis (proteostasis), distinct protein quality control (PQC) machineries operate on organelles, where they detect misfolded proteins, orphaned and mis ...
S. Schwabl, D. Teis
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Molecular mechanism of Asi- mediated protein quality control [PDF]
, 2020 Misfolded proteins in the membrane and lumen of the endoplasmic reticulum (ER) are eliminated by a quality control system called ER-associated protein degradation (ERAD).
Natarajan, Nivedita
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Nature Communications, 2021 Sarcopenia is a degenerative condition that consists in age-induced atrophy and functional decline of skeletal muscle cells (myofibers). A common hypothesis is that inducing myofiber hypertrophy should also reinstate myofiber contractile function but ...
L. Hunt +9 more
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Cell Death and Disease, 2021 Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown.
Zhipeng Su +16 more
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Mechanism of client selection by the protein quality control factor UBE2O
Nature Structural & Molecular Biology, 2022 The E2/E3 enzyme UBE2O ubiquitylates diverse clients to mediate important processes, including targeting unassembled ‘orphan’ proteins for quality control and clearing ribosomes during erythropoiesis.
M.-C.-J. Yip, Samantha Sedor, S. Shao
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Nuclear protein quality control in yeast: The latest INQuiries
Journal of Biological Chemistry, 2022 The nucleus is a highly organized organelle with an intricate substructure of chromatin, RNAs, and proteins. This environment represents a challenge for maintaining protein quality control, since non-native proteins may interact inappropriately with ...
Arun Kumar +2 more
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N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth
Redox Biology, 2022 Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular carcinoma (HCC) remains undefined. We explored the functional effects of MerTK and
Yongzhang Liu +13 more
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Cell & Bioscience, 2022 Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer +16 more
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Molecular Oncology, 2022 Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia +14 more
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Roles and Mechanisms of the Protein Quality Control System in Alzheimer’s Disease
International Journal of Molecular Sciences, 2021 Alzheimer’s disease (AD) is characterized by the deposition of senile plaques (SPs) and the formation of neurofibrillary tangles (NTFs), as well as neuronal dysfunctions in the brain, but in fact, patients have shown a sustained disease progression for ...
Ya-Ping Liu +7 more
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