Results 21 to 30 of about 19,078,260 (300)
Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network [PDF]
, 2020 Alzheimer’s Disease is driven by protein aggregation and is characterized by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raises the ...
Rüdiger, Stefan G.D. +1 more
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Molecular mechanism of Asi- mediated protein quality control [PDF]
, 2020 Misfolded proteins in the membrane and lumen of the endoplasmic reticulum (ER) are eliminated by a quality control system called ER-associated protein degradation (ERAD).
Natarajan, Nivedita
core +1 more source
Quality control of mislocalized and orphan proteins
Experimental Cell Research, 2021 A healthy and functional proteome is essential to cell physiology. However, this is constantly being challenged as most steps of protein metabolism are error-prone and changes in the physico-chemical environment can affect protein structure and function, thereby disrupting proteome homeostasis.
Kong, Ka-Yiu Edwin +3 more
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Quality Control of Orphaned Proteins [PDF]
Molecular Cell, 2018 The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular compartments, within which they are further organized into protein complexes. The maintenance of both levels of organization is crucial for normal cellular function. Newly made proteins that fail to be segregated to the correct compartment or assembled into the
Szymon, Juszkiewicz, Ramanujan S, Hegde
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Cell & Bioscience, 2022 Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer +16 more
doaj +1 more source
Molecular Oncology, 2022 Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia +14 more
doaj +1 more source
Protein quality control in the endoplasmic reticulum [PDF]
F1000Prime Reports, 2014 THE TOPOLOGICAL BARRIERS DEFINED BY BIOLOGICAL MEMBRANES ARE NOT IMPERMEABLE: from small solutes to intact proteins, specialized transport and translocation mechanisms adjust to the cell's needs. Here, we review the removal of unwanted proteins from the endoplasmic reticulum (ER) and emphasize the need to extend observations from tissue culture models ...
Koenig, Paul-Albert, Ploegh, Hidde L.
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Charactering the spoilage mechanism of “three sticks” of Jinhua ham
Food Science and Human Wellness, 2022 To investigate the spoilage characteristics of Jinhua ham, sensory scores, volatile compounds, biogenic amine, physicochemical parameters and microbial counts were evaluated between normal and spoiled hams.
Changyu Zhou +6 more
doaj +1 more source
Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]
, 2014 Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core +1 more source
Mitochondrial Protein Quality Control Mechanisms [PDF]
Genes, 2020 Mitochondria serve as a hub for many cellular processes, including bioenergetics, metabolism, cellular signaling, redox balance, calcium homeostasis, and cell death. The mitochondrial proteome includes over a thousand proteins, encoded by both the mitochondrial and nuclear genomes.
Pooja Jadiya, Dhanendra Tomar
openaire +2 more sources