Results 21 to 30 of about 1,305,355 (298)

Gene Signature Associated With Bromodomain Genes Predicts the Prognosis of Kidney Renal Clear Cell Carcinoma

Frontiers in Genetics, 2021
Bromodomain (BRD) proteins exhibit a variety of activities, such as histone modification, transcription factor recruitment, chromatin remodeling, and mediator or enhancer complex assembly, that affect transcription initiation and elongation.
Junwan Lu, Changrui Qian, Yongan Ji, Qiyu Bao, Bin Lu   +4 more
doaj   +1 more source

Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways

Cell & Bioscience, 2021
Background Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases.
Xianglin Mei, Hanhan Zhao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao   +8 more
doaj   +1 more source

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint [PDF]

, 2021
Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding.
Sub Cellular Protein Chemistry, Quandte, Matthias, Land, Aafke, McCaul, Nicholas, Sanders, Rogier W., Crooks, Ema T., Bontjer, Ilja, Binley, James M., van Zadelhoff, Guus, Braakman, Ineke, Cellular Protein Chemistry   +10 more
core   +1 more source

Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network [PDF]

, 2020
Alzheimer’s Disease is driven by protein aggregation and is characterized by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raises the ...
Rüdiger, Stefan G.D., Koopman, Margreet B.   +1 more
core   +2 more sources

SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates

npj Vaccines, 2022
At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology offers a flexible and scalable platform to address the urgent need for world-wide immunization in pandemic situations.
Reza Alimohammadi, Meysam Porgoo, Mohamad Eftekhary, Seyed Hossein Kiaie, Ehsan Ansari Dezfouli, Maryam Dehghani, Kaveh Nasrollahi, Talieh Malekshahabi, Maryam Heidari, Sedigheh Pouya, Masoumeh Alimohammadi, Dorsa Sattari Khavas, Mohammad Sadra Modaresi, Mohammad Hossein Ghasemi, Hamed Ramyar, Fatemeh Mohammadipour, Fateme Hamzelouei, Ahmadreza Mofayezi, Seyed Saeed Mottaghi, Amirhosein Rahmati, Mohsen Razzaznian, Vista Tirandazi, Mahdi Tat, Fatemeh Borzouee, Hossein Sadeghi, Melika Haji Mohammadi, Leila Rastegar, Seyed Milad Safar Sajadi, Hossein Ehsanbakhsh, Hamed Bazmbar, Zeinab Baghernejadan, Maedeh Shams Nouraei, Pouya Pazooki, Mina Pahlavanneshan, Khadijeh Alishah, Fateme Nasiri, Neda Mokhberian, Seyedeh Shima Mohammadi, Shima Akar, Hamidreza Niknam, Marzieh Azizi, Mohammad Ajoudanian, Mohammad Hossein Moteallehi-Ardakani, Seyed Ali Mousavi Shaegh, Reihaneh Ramezani, Vahid Salimi, Reza Moazzami, Seyed Mahmoud Hashemi, Somaye Dehghanizadeh, Vahid Khoddami   +49 more
doaj   +1 more source

Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
doaj   +1 more source

Protein quality control in the nucleus [PDF]

Current Opinion in Cell Biology, 2016
The nucleus is the repository for the eukaryotic cell's genetic blueprint, which must be protected from harm to ensure survival. Multiple quality control (QC) pathways operate in the nucleus to maintain the integrity of the DNA, the fidelity of the DNA code during replication, its transcription into mRNA, and the functional structure of the proteins ...
Ramon D, Jones, Richard G, Gardner
openaire   +2 more sources

Quality Control of Orphaned Proteins [PDF]

Molecular Cell, 2018
The billions of proteins inside a eukaryotic cell are organized among dozens of sub-cellular compartments, within which they are further organized into protein complexes. The maintenance of both levels of organization is crucial for normal cellular function. Newly made proteins that fail to be segregated to the correct compartment or assembled into the
Szymon, Juszkiewicz, Ramanujan S, Hegde
openaire   +2 more sources

Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling

Cell Death and Disease, 2021
Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown.
Zhipeng Su, Shengnan Han, Qiumei Jin, Ningning Zhou, Junwan Lu, Fugen Shangguan, Shiyi Yu, Yongzhang Liu, Lu Wang, Jianglong Lu, Qun Li, Lin Cai, Chengde Wang, Xiaohe Tian, Lingyan Chen, Weiming Zheng, Bin Lu   +16 more
doaj   +1 more source

Quality control of mislocalized and orphan proteins

Experimental Cell Research, 2021
A healthy and functional proteome is essential to cell physiology. However, this is constantly being challenged as most steps of protein metabolism are error-prone and changes in the physico-chemical environment can affect protein structure and function, thereby disrupting proteome homeostasis.
Kong, Ka-Yiu Edwin, Coelho, João P.L., Feige, Matthias J., Khmelinskii, Anton   +3 more
openaire   +2 more sources