Results 41 to 50 of about 436,505 (303)

Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation. [PDF]

PLoS ONE, 2009
Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Bernhard Helk, Kurt Forrer, Heidi Zhang, Cornelius Fritsch, Holger Heine, Bernhardt L Trout   +8 more
doaj   +1 more source

Introduction and technical survey: protein aggregation and fibrillogenesis

, 2012
In this chapter we provided the overall background to the subject of protein aggregation and fibrillogenesis in amyloidogenesis, with introduction and brief discussion of the various topics that are included with the coming chapters.
Harris, J.R., Milton, N.G.N.
core   +1 more source

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

eLife, 2022
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer.
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink   +16 more
doaj   +1 more source

Contribution of Milk components on Protein Aggregation

, 2023
Protein aggregation is a known health hazard that has been implicated in more than 50 human diseases. These diseases have been linked to lifestyle as they mostly prevail in the western world.
Lor, Kong Peng, NC DOCKS at East Carolina University   +1 more
core  

Research Progress on the Effects of Parameters of Alkali Extraction and Acid Precipitation on the Denaturation, Aggregation, and Rheological Characteristics of Soybean Protein Isolate [PDF]

Shipin Kexue
pH, NaCl and temperature are important process parameters for the manufacturing of soybean protein isolate (SPI). pH and NaCl affect protein aggregation by modifying the surface charge and electrostatic repulsion, whereas temperature affects protein ...
MENG Ang, LUAN Binyu, GUO Boli, ZHANG Bo, YU Wenhua, CUI Kai
doaj   +1 more source

Pathological AT1R-B2R Protein Aggregation and Preeclampsia

Cells, 2021
Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria.
Ursula Quitterer, Said AbdAlla
doaj   +1 more source

Aging and the aggregating proteome

Frontiers in Genetics, 2012
For all organisms promoting protein homeostasis is a high priority in order to optimize cellular functions and resources. However, there is accumulating evidence that aging leads to a collapse in protein homeostasis and widespread non-disease protein ...
Della C David
doaj   +1 more source

FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis

Frontiers in Neuroscience, 2020
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative illness that is unremittingly fatal and for which no effective treatment exists. All forms of ALS are characterized by protein aggregation.
Hiroaki Kaku, Hiroaki Kaku, Alexander V. Ludlow, Michael F. Gutknecht, Thomas L. Rothstein, Thomas L. Rothstein   +5 more
doaj   +1 more source

Prediction of Protein Aggregation Propensity via Data-driven Approaches_Database

, 2023
 Protein aggregation is the phenomenon which occurs when misfolded or unfolded protein physically binds together and can cause the development of various amyloidosis diseases.
Myeonghun Lee (13117707), Sun Jiwon (15060016), Minseon Kim (15059212)   +2 more
core   +1 more source

Chaperone Like Attributes of Biogenic Fluorescent Gold Nanoparticles: Potential to Alleviate Toxicity Induced by Intermediate State Fibrils Against Neuroblastoma Cells

Frontiers in Chemistry, 2019
In general, neurodegenerative disorders have a great deal of correlation with the misfolded as well as aggregated forms of protein-based macromolecules.
Anzar Abdul Mujeeb, Khan Farheen Badre Alam, Ansam Wadia Faid Alshameri, Fauzia Jamal, Saba Farheen, Mohd Kashif, Anees Ahmed, Irfan Ahmad Ghazi, Mohammad Owais   +8 more
doaj   +1 more source