Results 51 to 60 of about 432,033 (262)
Nanoparticles in relation to peptide and protein aggregation
International Journal of Nanomedicine, 2014 Masihuz Zaman, Ejaz Ahmad, Atiyatul Qadeer, Gulam Rabbani, Rizwan Hasan Khan Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India Abstract: Over the past two decades, there has been considerable research interest in the use of
Zaman M +4 more
doaj
CPAD, Curated Protein Aggregation Database: A Repository of Manually Curated Experimental Data on Protein and Peptide Aggregation. [PDF]
PLoS ONE, 2016 Accurate distinction between peptide sequences that can form amyloid-fibrils or amorphous β-aggregates, identification of potential aggregation prone regions in proteins, and prediction of change in aggregation rate of a protein upon mutation(s) are ...
A Mary Thangakani +5 more
doaj +1 more source
mAbs, 2021 Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature.
Salla Valtonen +5 more
doaj +1 more source
Protein aggregation. Studies of larger aggregates of C-phycocyanin [PDF]
Biochemical Journal, 1968 Aggregates of phycocyanin sedimenting at 17s, 22s and 27s are demonstrated to constitute more than 40% of crude blue–green-algal extracts, pH6·0 and I0·1, and are retained in highly purified preparations. Sedimentation-velocity studies of the large aggregates as a function of pH are reported. Sucrose-density-gradient experiments performed as a function
J J, Lee, D S, Berns
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Amyloidogenic regions and interaction surfaces overlap in globular proteins related to conformational diseases. [PDF]
PLoS Computational Biology, 2009 Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure.
Virginia Castillo, Salvador Ventura
doaj +1 more source
Protein aggregation in Huntington’s disease
Biochimie, 2002 The presence of an expanded polyglutamine produces a toxic gain of function in huntingtin. Protein aggregation resulting from this gain of function is likely to be the cause of neuronal death. Two main mechanisms of aggregation have been proposed: hydrogen bonding by polar-zipper formation and covalent bonding by transglutaminase-catalyzed cross ...
Hoffner, Guylaine, Djian, Philippe
openaire +3 more sources
Protein aggregation and lyophilization: Protein structural descriptors as predictors of aggregation propensity [PDF]
Computers & Chemical Engineering, 2013 Lyophilization can induce aggregation in therapeutic proteins, but the relative importance of protein structure, formulation and processing conditions are poorly understood. To evaluate the contribution of protein structure to lyophilization-induced aggregation, fifteen proteins were co-lyophilized with each of five excipients.
Brock C. Roughton +4 more
openaire +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source