Hypothesis : soluble Aβ oligomers in association with redox-active metal ions are the optimal generators of reactive oxygen species in Alzheimer's disease [PDF]
, 2010 Considerable evidence points to oxidative stress in the brain as an important event in the early stages of Alzheimer's disease (AD). The transition metal ions of Cu, Fe, and Zn are all enriched in the amyloid cores of senile plaques in AD.
Tabner, Brian J +2 more
core +5 more sources
Site Specific NMR Characterization of Abeta-40 Oligomers Cross Seeded by Abeta-42 Oligomers [PDF]
, 2022 Extracellular accumulation of β amyloid peptides of 40 (Aβ40) and 42 residues (Aβ42) has been considered as one of the hallmarks in the pathology of Alzheimer’s disease.
Ho-I, Ma +9 more
core +2 more sources
Solid–Liquid–Gas Phase Equilibria for Small Phenylene-Thiophene Co-Oligomers
, 2022 This work reports a comprehensive experimental evaluation of the solid–liquid–gas phase equilibria for five representative phenylene-thiophene co-oligomers (3-ring aromatic compounds having both phenyl and thienyl units).
Luís M. N. B. F. Santos (4693825) +9 more
core +1 more source
Synthesis and Biophysical Studies of High Affinity Morpholino Oligomers Containing G-clamp Analogs [PDF]
, 2023 Synthesis of chlorophosphoramidate morpholino monomers containing tricyclic cytosine analogs phenoxazine, G-clamp, and G8AE-clamp were achieved and incorporated into 12-mer oligonucleotides using trityl-chemistry by automated synthesizer ...
Martin , Egli +5 more
core +2 more sources
Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]
, 2012 Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Felix Schmidt +17 more
core +2 more sources
Nitrogen Backbone Oligomers [PDF]
Scientific Reports, 2015 AbstractWe found that nitrogen and hydrogen directly react at room temperature and pressures of ~35 GPa forming chains of single-bonded nitrogen atom with the rest of the bonds terminated with hydrogen atoms - as identified by IR absorption, Raman, X-ray diffraction experiments and theoretical calculations.
Hongbo Wang +5 more
openaire +5 more sources
Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease
Frontiers in Molecular Biosciences, 2018 We have recently reported on the preparation of a membrane-associated β-barrel Pore-Forming Aβ42 Oligomer (βPFOAβ42). It corresponds to a stable and homogeneous Aβ42 oligomer that inserts into lipid bilayers as a well-defined pore and adopts a specific ...
Montserrat Serra-Batiste +6 more
doaj +1 more source
Paradigm study on risk assessment methodology of oligomers in food contact materials
Zhongguo shipin weisheng zazhi, 2023 Risk assessment of non-intentionally added substances， including oligomers， in food contact materials is of great importance for ensuring food safety. Research articles and risk assessment reports at home and abroad were collected to analyze the sources ...
ZHOU Shiqi +4 more
doaj +1 more source
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
EMBO Molecular Medicine, 2022 Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive.
Julia Ring +39 more
doaj +1 more source
Bioactive oligomers from natural polyhydroxyalkanoates and their synthetic analogues [PDF]
, 2017 Contemporary reports on the bioactive oligomers derived from natural aliphatic (co)polyesters (PHA) and their synthetic analogues, formed through anionic ring-opening polymerization (ROP) of β-substituted β-lactones are presented.
Radecka, I. +11 more
core +2 more sources