Results 41 to 50 of about 188,463 (312)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
ADMET and DMPK, 2016 This commentary addresses data quality in equilibrium solubility measurement in aqueous solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to measure equilibrium solubility of ionizable drug-like molecules as a function of pH.
Alex Avdeef +8 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Zhipu XuebaoPoly (glycolic acid) (PGA) is an environmentally friendly, biodegradable polymer commonly utilized in biomedical applications. Due to its high thermal deformation temperature, favorable mechanical properties, and effective gas barrier capabilities, PGA ...
Sheng-feng LIU +7 more
doaj +1 more source
Polycarbonate/Titania Hybrid Films with Localized Photo-Induced Magnetic-Phase Transition
Nanomaterials, 2020 Materials that exhibit the photo-induced magnetic-phase transition of titania are receiving significant attention because they can be easily switched between diamagnetism and paramagnetism by UV irradiation.
Shuta Hara +7 more
doaj +1 more source
Analysis of Pseudo-Symmetry in Protein Homo-Oligomers
, 2020 Symmetry plays a significant role in protein structural assembly and function. This is especially true for large homo-oligomeric protein complexes due to stability and finite control of function.
Catherine Jenifer Rajam Rajendran (5931113)
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
3,5-Bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one
Molbank, 2012 3,5-Dichloro-4H-1,2,6-thiadiazin-4-one 1 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 4 (2.2 equiv.) and Pd(Ph3P)2Cl2 (5 mol%) in acetonitrile at ca. 82 °C to give 3,5-bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one 5 in 93% yield.
Panayiotis A. Koutentis +1 more
doaj +1 more source