Results 31 to 40 of about 188,463 (312)

Brain injury, neuroinflammation and Alzheimer’s disease

Frontiers in Aging Neuroscience, 2013
With as many as 300,000 United States troops in Iraq and Afghanistan having suffered head injuries (Miller 2012), traumatic brain injury (TBI) has garnered much recent attention.
Joshua eBreunig, Marie-Victoire eGuillot-Sestier, Terrence eTown   +2 more
doaj   +1 more source

Synthesis and Properties of Twisted and Helical Azulene Oligomers and Azulene‐Based Polycyclic Hydrocarbons

ChemistryOpen, 2023
The construction of 1,2‐position‐connected azulene oligomers was achieved. In the crystal packing structure of the terazulene, two molecules of (Ra)‐ and (Sa)‐configurations formed a pair.
Prof. Dr. Takahiro Tsuchiya, Makoto Higashibeppu, Prof. Dr. Yasuhiro Mazaki   +2 more
doaj   +1 more source

A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer’s disease

Cell Stress, 2022
Alzheimer’s disease (AD) is the most common form of dementia with millions of people affected worldwide. Pathophysiological manifestations of AD include the extracellular accumulation of amyloid beta (Abeta) pep-tides, products of the proteolytic ...
Jelena Tadic, Julia Ring, Andrea Jerkovic, Selena Ristic, Marta Maglione, Jörn Dengjel, Stephan J. Sigrist, Tobias Eisenberg   +7 more
doaj   +1 more source

Consequences of Dispersity on the Self-Assembly of ABA-Type Amphiphilic Block Co-Oligomers

, 2018
Intriguingly, little is known about the impact of dispersity on the crystallization driven self-assembly (CDSA) of amphiphilic block copolymers in aqueous media.
Anindita Das (306285), E. W. Meijer (1454104), Gilian Klerks (5105477), René P. M. Lafleur (5105480), Anja R. A. Palmans (1454110), Katja Petkau-Milroy (2083318), Bas van Genabeek (2567818)   +6 more
core   +1 more source

Oligomeropathies, inflammation and prion protein binding

Frontiers in Neuroscience, 2022
The central role of oligomers, small soluble aggregates of misfolded proteins, in the pathogenesis of neurodegenerative disorders is recognized in numerous experimental conditions and is compatible with clinical evidence.
Gianluigi Forloni, Pietro La Vitola, Claudia Balducci   +2 more
doaj   +1 more source

Bacterial responses to plant antimicrobials: the case of alkannin and shikonin derivatives

Frontiers in Pharmacology, 2023
Alkannin, shikonin and their derivatives (A/S) are secondary metabolites produced in the roots of certain plants of the Boraginaceae family such as Lithospermum erythrorhizon Siebold & Zucc. and Alkanna tinctoria (L.) Tausch.
Angélique Rat, Antigoni E. Koletti, Antigoni E. Koletti, Nebojša Rodić, Nebojša Rodić, Vassilios P. Papageorgiou, Vassilios P. Papageorgiou, Anne Willems, Andreana N. Assimopoulou, Andreana N. Assimopoulou   +9 more
doaj   +1 more source

C^α-Methyl, C^α-n-Propylglycine Homo-oligomers

, 2016
A series of Nα-protected, monodispersed homo-oligopeptide esters to the octamer level from l-Cα-methyl, Cα-n-propylglycine [or Cα-methylnorvaline, (αMe)Nva] has been synthesized by solution methods and fully characterized.
Quirinus B. Broxterman (2462869), Marco Crisma (1522954), Ettore Benedetti (2257849), Fernando Formaggio (1760632), Catherine Corbier (602994), Bernard Kaptein (2336899), Michele Saviano (166208), Claudio Toniolo (1723621), Pasquale Palladino (807619)   +8 more
core   +1 more source

High-Temperature Polymer Components Reimagined: Scalable Syntheses and de novo Routes to Structurally Versatile Precursors

Журнал органічної та фармацевтичної хімії
Developing efficient and scalable synthetic protocols for key polymer precursors is crucial to advancing high-performance materials designed to withstand severe thermal environments.
Roman M. Kurganov, Oleh V. Svaliavyn, Yevgen O. Pashchenko, Denis O. Savchenko, Alexander B. Rozhenko, Serhiy V. Ryabukhin, Dmitriy M. Volochnyuk   +6 more
doaj   +1 more source

Detection of Amyloid-β(1–42) Aggregation With a Nanostructured Electrochemical Sandwich Immunoassay Biosensor

Frontiers in Bioengineering and Biotechnology, 2022
Amyloid-β(1–42) [Aβ(1–42)] oligomer accumulations are associated with physiologic alterations in the brains of individuals with Alzheimer’s disease. In this study, we demonstrate that a nanostructured gold electrode with deposited gold nanoparticles ...
Bing-Yu Wang, Bien-Chen Gu, Gou-Jen Wang, Gou-Jen Wang, Yuan-Han Yang, Yuan-Han Yang, Yuan-Han Yang, Chia-Che Wu, Chia-Che Wu, Chia-Che Wu   +9 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source