Results 71 to 80 of about 659,948 (302)

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes. [PDF]

PLoS ONE, 2016
Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is likely
Jakob Domert, Christopher Sackmann, Emelie Severinsson, Lotta Agholme, Joakim Bergström, Martin Ingelsson, Martin Hallbeck   +6 more
doaj   +1 more source

Alpha-Synuclein Interactions with Membranes

, 2011
Synucleinopathies are a group of neurodegenerative disorders that share common pathological intracellular deposits that contain aggregates of the protein ┙-synuclein. Substantial evidence suggests that fibril formation by ┙-synuclein is a critical step in the development of Parkinson's disease (PD).
Pirc, Katja, Poklar Ulrih, Nataša
openaire   +3 more sources

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases. [PDF]

PLoS ONE, 2018
Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.
Thomas Mund, Masami Masuda-Suzukake, Michel Goedert, Hugh R Pelham   +3 more
doaj   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Vassallo, Neville, Caruana Grech Perry, Mario   +1 more
core  

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K.

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
Chad M Rienstra, Julia M. George (386756), Rikardsen, LK, Shin W Lee, Lars K. Rikardsen (386754), Gemma Comellas, Luisel R. Lemkau, Shin W. Lee (386753), Lars K Rikardsen, Rienstra Chad M., Lee, SW, Lee Shin W., Woods, WS, Lemkau, LR, Julia M. George, Luisel R. Lemkau (386752), Comellas, G, George, JM, Rikardsen Lars K., Wendy S. Woods (386755), Wendy S Woods, Woods Wendy S., Chad M. Rienstra, George Julia M., Shin W. Lee, Rienstra, CM, Lars K. Rikardsen, Chad M. Rienstra (386757), Luisel R Lemkau, Julia M George, Wendy S. Woods, Lemkau Luisel R., Comellas Gemma, Gemma Comellas (371865)   +33 more
core   +1 more source

Tau and Alpha Synuclein Synergistic Effect in Neurodegenerative Diseases: When the Periphery Is the Core. [PDF]

, 2020
In neuronal cells, tau is a microtubule-associated protein placed in axons and alpha synuclein is enriched at presynaptic terminals. They display a propensity to form pathologic aggregates, which are considered the underlying cause of Alzheimer's and ...
Melli, Giorgia, Vacchi, Elena, Giorgia Melli, Elena Vacchi, Kaelin-Lang, Alain, Alain Kaelin-Lang   +5 more
core   +1 more source

Label‐Free Detection of a Neurotransmitter Using an Aptamer‐Functionalized Amorphous IGZO Transistor

Advanced Materials Interfaces, EarlyView.
An aptamer‐functionalized amorphous IGZO thin‐film transistor enables label‐free electrical detection of the neurotransmitter serotonin under liquid‐gated operation. Stepwise surface functionalization ensures stable biomolecule integration and efficient electrostatic coupling.
Ngoc Thanh Ho, Sina Jamali, Nam‐Trung Nguyen, Tuan‐Khoa Nguyen   +3 more
wiley   +1 more source

In situ exogenous alpha-synuclein aggregates inhibit murine ventricular voltage-gated inward sodium and outward potassium currents

Journal of Parkinson’s Disease
Background Alpha-synuclein is associated with neurodegeneration in Parkinson's disease (PD). Recent studies have increasingly recognized incidences of cardiac complaints in PD patients.
Bonn Lee, Shiraz Ahmad, Charlotte E Edling, Hugh R Matthews, Christopher L-H Huang, Fiona EN LeBeau, Kamalan Jeevaratnam   +6 more
doaj   +1 more source