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Interaction of alpha-synuclein with lipids
2022Alpha-synuclein (α-syn) is a natively unfolded protein that is abundantly expressed in the central nervous system. Although it has been shown to be involved in neurotransmission and cognition, its exact functions remain elusive. The misfolding of this protein into β-sheet-rich amyloid structures and subsequent aggregation has been associated with ...
Neha, Kachappilly +3 more
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The fold of alpha-synuclein fibrils.
Proceedings of the National Academy of Sciences of the United States of America, 2008The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases. In Parkinson's disease it is believed that the aggregation of alpha-synuclein (alpha-syn) from monomers by intermediates into amyloid fibrils is the toxic disease-causative mechanism.
Vilar, Marcal +8 more
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Prion Properties of Alpha-Synuclein
Molecular Biology, 2019The prion properties of alpha-synuclein, a key aggregating protein involved in the pathogenesis of so-called synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and its various conformers are discussed.
A L, Schwarzman +3 more
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Alpha-synuclein and Parkinson's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in alpha-syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease (PD). The physiological functions of alpha-
RECCHIA, ALESSANDRA +5 more
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Alpha-synuclein and Parkinson's disease
Cellular and Molecular Life Sciences, 2000The involvement of alpha-synuclein in neurodegenerative diseases was first suspected after the isolation of an alpha-synuclein fragment (NAC) from amyloid plaques in Alzheimer's disease (AD). Later, two different alpha-synuclein mutations were shown to be associated with autosomal-dominant Parkinson's disease (PD), but only in a small number of ...
C B, Lücking, A, Brice
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Ubiquitination of alpha-synuclein.
Biochemistry, 2005Filamentous alpha-synuclein depositions are the defining hallmarks of a subset of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. We previously reported that alpha-synuclein in those brains are extensively phosphorylated at Ser129 [Fujiwara et al. (2002) Nat. Cell Biol.
Takashi, Nonaka +2 more
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Alpha-synuclein and neurodegenerative diseases
Nature Reviews Neuroscience, 2001In recent years, two developments have imparted a new direction to research on the aetiology and pathogenesis of Parkinson's disease. First, the discovery that a missense mutation in the α-synuclein gene is a rare genetic cause of Parkinson's disease.
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Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation.
Glycobiology, 2006Recent studies have begun to investigate the role of agrin in brain and suggest that agrin's function likely extends beyond that of a synaptogenic protein. Particularly, it has been shown that agrin is associated with the pathological lesions of Alzheimer's disease (AD) and may contribute to the formation of beta-amyloid (Abeta) plaques in AD.
I-Hsuan, Liu +5 more
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