Results 61 to 70 of about 659,948 (302)

Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders

Bioengineering & Translational Medicine
Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein.
Jose Miguel Flores‐Fernandez, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juarez, Sara Amidian, Xiongyao Wang, Caleb Duckering, Andrew Fang, Sara Reithofer, Liang Ma, Leonardo M. Cortez, Valerie L. Sim, Gültekin Tamgüney, Holger Wille   +13 more
doaj   +1 more source

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice

, 2010
BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Liss Birgit, Paolo Calabresi, Auburger Georg, Silke Nuber, Javier Fernández-Ruiz, Lastres-Becker, Isabel, Double Kay L., Auburger, Georg, Lüddens Hartmut, Nuber Silke, Fernández-Ruiz, Javier, Fernández-Ruiz Javier, Gispert, Suzana, Schlaudraff Falk, Nuber, Silke, García-Arencibia Moisés, García-Arencibia, Moisés, Manfred Gerlach, Gerlach, Manfred, Double, Kay L., Kay L. Double, Alexander Kurz, Tantucci Michela, Bonin Michael, Bockhart, Vanessa, Gispert Suzana, Calabresi, Paolo, Lüddens, Hartmut, Moisés García-Arencibia, Tozzi Alessandro, Michael Bonin, Michela Tantucci, Schlaudraff, Falk, Hartmut Lüddens, Lastres-Becker Isabel, Isabel Lastres-Becker, Tantucci, Michela, Birgit Liss, Wüllner Ullrich, Ullrich Wüllner, Kurz Alexander, Vanessa Bockhart, Liss, Birgit, Falk Schlaudraff, Kurz, Alexander, Suzana Gispert, Bonin, Michael, Calabresi Paolo, Wüllner, Ullrich, Georg Auburger, Tozzi, Alessandro, Kay L Double, Alessandro Tozzi, Gerlach Manfred, Bockhart Vanessa   +54 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Evaluation of Stp2p-dependent alpha-Synuclein Toxicity in Yeast: Role of GAPDH? [PDF]

Impulse: The Premier Undergraduate Neuroscience Journal, 2006
Parkinson's disease (PD) is linked to alpha-synuclein misfolding and aggregation in the substantia nigra par compacta cells of the brain. Discovering and characterizing factors that regulate alpha-synuclein misfolding and toxicity have high therapeutic ...
Arun George Paul
doaj  

Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage

Global Medical & Health Communication, 2022
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances.
Yuliarni Syafrita, Restu Susanti
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Alpha-Synuclein Aggregates Associated with Mitochondria in Tunnelling Nanotubes

, 2020
The interaction of α-synuclein with mitochondria in both typical and atypical Parkinson's disease is a critical component of degeneration. The mechanism of cell-to-cell propagation of pathological α-synuclein in synucleinopathies is unclear ...
Kovarova, Jaromira, Valdinocci, Dario, Neuzil, Jiri, Pountney, Dean L   +3 more
core   +1 more source

The relationship of alpha-synuclein to mitochondrial dynamics and quality control

Frontiers in Molecular Neuroscience, 2022
Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the mitochondrial network and effective mitochondrial quality control mechanisms including the mitochondrial-derived vesicle pathway and mitophagy ...
Naomi J. Thorne, David A. Tumbarello
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source