Results 31 to 40 of about 61,554 (301)

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy. [PDF]

, 2015
BackgroundMultiple system atrophy (MSA) is a neurodegenerative disease characterized by parkinsonism, ataxia and dysautonomia. Histopathologically, the hallmark of MSA is the abnormal accumulation of alpha-synuclein (α-syn) within oligodendroglial cells,
Adame, Anthony, Mandler, Markus, Mante, Michael, Masliah, Eliezer, Mattner, Frank, Patrick, Christina, Rockenstein, Edward, Santic, Radmila, Schmidhuber, Sabine, Schmidt, Walter, Schneeberger, Achim, Valera, Elvira, Weninger, Harald   +12 more
core   +2 more sources

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface

Journal of Analytical Methods in Chemistry, 2019
Parkinson’s disease (PD) is a progressive health issue and influences an increasingly larger number of people, especially at older ages, affecting the central nervous system (CNS).
Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li   +3 more
doaj   +1 more source

Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Scientific Reports, 2023
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need.
Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, L. Stanley Qi, Birgitt Schüle   +7 more
doaj   +1 more source

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice [PDF]

, 2010
BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Auburger, Georg, Bockhart, Vanessa, Bonin, Michael, Calabresi, Paolo, Double, Kay L., Fernández-Ruiz, Javier, García-Arencibia, Moisés, Gerlach, Manfred, Gispert, Suzana, Kurz, Alexander, Lastres-Becker, Isabel, Liss, Birgit, Lüddens, Hartmut, Nuber, Silke, Schlaudraff, Falk, Tantucci, Michela, Tozzi, Alessandro, Wüllner, Ullrich   +17 more
core   +1 more source

Alpha-Synuclein Aggregation in Parkinson's Disease [PDF]

Frontiers in Medicine, 2021
Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region urging toward neuronal loss. Over the decade, various key findings from clinical perspective to molecular pathogenesis have aided in understanding the genetics with assorted ...
E. Srinivasan, E. Srinivasan, G. Chandrasekhar, P. Chandrasekar, K. Anbarasu, A. S. Vickram, Rohini Karunakaran, R. Rajasekaran, P. S. Srikumar   +8 more
openaire   +3 more sources

Deposits of disease-associated alpha-synuclein may be present in the dura mater in Lewy body disorders: implications for potential inadvertent transmission by surgery

Free Neuropathology, 2020
Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties.
Ellen Gelpi, Naomi P. Visanji, Selma Hönigschnabl, Angelika Reiner, Peter Fischer, Anthony Lang, Herbert Budka, Gabor G. Kovacs   +7 more
doaj   +1 more source

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]

, 2015
BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott, Mante, Michael, Masliah, Eliezer, Rockenstein, Edward, Valera, Elvira   +4 more
core   +2 more sources

Alpha Synuclein: Neurodegeneration and Inflammation

International Journal of Molecular Sciences, 2023
Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson’s disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role. This review analyzes the activities of α-Syn, in different conformational states, monomeric, oligomeric and fibrils ...
openaire   +2 more sources

Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk

Frontiers in Cellular Neuroscience, 2021
Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions.
Alix Booms, Gerhard A. Coetzee
doaj   +1 more source