Results 31 to 40 of about 33,680 (119)
The relationship of alpha-synuclein to mitochondrial dynamics and quality control
Frontiers in Molecular Neuroscience, 2022 Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the mitochondrial network and effective mitochondrial quality control mechanisms including the mitochondrial-derived vesicle pathway and mitophagy ...
Naomi J. Thorne, David A. Tumbarello
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Alpha synuclein in hematopoiesis and immunity
Heliyon, 2019 Parkinson's disease (PD) is the second most common neurodegenerative condition and intracellular deposition of Lewy bodies in the substantia nigra (SN), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. α-synuclein (syn) is a
Yu Pei, Robert W. Maitta
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Ubiquitination of alpha-synuclein filaments by Nedd4 ligases. [PDF]
PLoS ONE, 2018 Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.
Thomas Mund +3 more
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Journal of Parkinson’s DiseaseBackground Alpha-synuclein is associated with neurodegeneration in Parkinson's disease (PD). Recent studies have increasingly recognized incidences of cardiac complaints in PD patients.
Bonn Lee +6 more
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Natural Product Communications, 2015 Alpha-synuclein belongs to the class of intrinsically disordered proteins lacking a well-folded structure under physiological conditions. The conversion of alpha-synuclein from a soluble monomer to an insoluble fibril may underlie the neurodegeneration ...
Azucena Gonzalez-Horta
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Microtubule depolymerization potentiates alpha-synuclein oligomerization
Frontiers in Aging Neuroscience, 2010 Parkinson’s disease (PD) is associated with perturbed mitochondria function and alpha-synuclein fibrillization. We evaluated potential mechanistic links between mitochondrial dysfunction and alpha-synuclein aggregation.
Russell H Swerdlow, Catarina Oliveira
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Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson’s Disease
Journal of Parkinson’s Disease, 2017 Background: Parkinson disease (PD) is neurodegenerative disorder characterized by tremor, rigidity and bradykinesia and pathologically by the deposition of alpha-synuclein within different tissues. We, and others, have reported the detection of cutaneous
Christopher H. Gibbons +2 more
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Frontiers in Neuroscience, 2019 Accumulation and aggregation of misfolded alpha-synuclein is believed to be a cause of Parkinson’s disease (PD). Phosphorylation of alpha-synuclein at S129 is known to be associated with the pathological misfolding process, but efforts to investigate the
Cristina Cariulo +15 more
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F1000Research, 2014 The accumulation of misfolded a-synuclein is mechanistically linked to neurodegeneration in Parkinson’s disease (PD) and other alpha-synucleinopathies. However, how alpha-synuclein causes neurodegeneration is unresolved.
Yan Liu +5 more
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Frontiers in Aging Neuroscience, 2020 Parkinson’s disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies.
Sarah M. Hernandez +2 more
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