Results 31 to 40 of about 659,948 (302)

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress [PDF]

, 2010
The presynaptic protein alpha-synuclein has received much attention because its gain-of-function is associated with Parkinson’s disease. However, its physiological function is still poorly understood.
Paul Thornalley, Gispert, Suzana, Kurz, Alexander, Naila Rabbani, Suzana Gispert, Bonin, Michael, Thornalley, Paul J., Michael Bonin, Rabbani, Naila, Michael Walter, Georg Auburger, Auburger, Georg, Alexander Kurz, Thornalley, Paul, Walter, Michael   +14 more
core   +1 more source

Alpha-synuclein levels in blood plasma decline with healthy aging. [PDF]

PLoS ONE, 2015
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies.
Niklas K U Koehler, Elke Stransky, Mirjam Meyer, Susanne Gaertner, Mona Shing, Martina Schnaidt, Maria S Celej, Thomas M Jovin, Thomas Leyhe, Christoph Laske, Anil Batra, Gerhard Buchkremer, Andreas J Fallgatter, Dorothee Wernet, Elke Richartz-Salzburger   +14 more
doaj   +1 more source

The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein

Molecular Neurodegeneration, 2010
Background Parkinson's disease (PD) involves the selective damage of dopaminergic neuron cells resulting from the accumulation and fibril formation of alpha-synuclein.
Kobayashi Natsuki, Kobayashi Masaki, Harada Ryuichi, Kim Jihoon, Sode Koji   +4 more
doaj   +1 more source

Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation

Neurobiology of Disease, 2020
In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Christopher Mezias, Nolwen Rey, Patrik Brundin, Ashish Raj   +3 more
doaj   +1 more source

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]

, 2013
Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Christine L Kragh, Lubetzki Catherine, Kragh, Christine L, Manuela Neumann, Neumann, Manuela, Lubetzki, Catherine, Bernard Zalc, Glenda M Halliday, Jensen, Poul H, Gai, Wei-Ping, Wei-Ping Gai, Kragh, Christine, Zalc Bernard, Jensen, Poul, Christian Haass, Fillon, Gwenaëlle, Gysbers Amanda, Philipp J Kahle, Richter-Landsberg, Christiane, Fillon Gwenaëlle, Halliday, Glenda M., Hansen, Hanne D, Gwenaëlle Fillon, Gai, Wei Ping, Kragh, Christine L., Hansen, Hanne, Amanda Gysbers, Catherine Lubetzki, Smith, Wanli, Christiane Richter-Landsberg, Kahle Philipp J., Zalc, Bernard, Haass Christian, Richter-Landsberg, Christian, Halliday, Glenda,, Kahle, Philipp J., Kahle, Philipp, Gysbers, Amanda, Hansen, Hanne D., Jensen, Poul H., Richter-Landsberg Christiane, Halliday Glenda M., Kahle, Philipp J, Halliday, Glenda M, Kragh Christine L., Jensen Poul H., Neumann Manuela, Hansen Hanne D., Poul H Jensen, Haass, Christian, Hanne D Hansen, Gai Wei-Ping   +51 more
core   +1 more source

Alpha Synuclein: Neurodegeneration and Inflammation

International Journal of Molecular Sciences, 2023
Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson’s disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role. This review analyzes the activities of α-Syn, in different conformational states, monomeric, oligomeric and fibrils ...
openaire   +2 more sources

Deposits of disease-associated alpha-synuclein may be present in the dura mater in Lewy body disorders: implications for potential inadvertent transmission by surgery

Free Neuropathology, 2020
Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties.
Ellen Gelpi, Naomi P. Visanji, Selma Hönigschnabl, Angelika Reiner, Peter Fischer, Anthony Lang, Herbert Budka, Gabor G. Kovacs   +7 more
doaj   +1 more source

Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Scientific Reports, 2023
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need.
Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, L. Stanley Qi, Birgitt Schüle   +7 more
doaj   +1 more source

Alpha-synuclein spreading in Parkinson’s disease [PDF]

Frontiers in Neuroanatomy, 2014
Formation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson's disease (PD), the aggregation-prone protein alpha-synuclein (α-syn) is the culprit. In the past few years, another piece of the puzzle has been added with data suggesting that α-syn may self-propagate, thereby ...
Recasens, Ariadna, Dehay, Benjamin
openaire   +4 more sources

High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface

Journal of Analytical Methods in Chemistry, 2019
Parkinson’s disease (PD) is a progressive health issue and influences an increasingly larger number of people, especially at older ages, affecting the central nervous system (CNS).
Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li   +3 more
doaj   +1 more source