Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. [PDF]
PLoS ONE, 2010 BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra ...
Zhongwang Yu +6 more
doaj +1 more source
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
PLoS ONE, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Margot Fournier +22 more
doaj +1 more source
Neurobiology of Disease, 2023 Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza +19 more
doaj +1 more source
C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]
, 2008 Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper +38 more
core +8 more sources
Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
Frontiers in Molecular Neuroscience, 2019 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields +2 more
doaj +1 more source
Pharmaceutics, 2023 The development of effective disease-modifying therapies to halt Parkinson’s disease (PD) progression is required. In a subtype of PD patients, alpha-synuclein pathology may start in the enteric nervous system (ENS) or autonomic peripheral nervous system.
Maria Izco +5 more
doaj +1 more source
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]
, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D +5 more
core +2 more sources
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease [PDF]
, 2015 Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown.
Andrey Y. Abramov +16 more
core +5 more sources
Alpha-synuclein levels in blood plasma decline with healthy aging. [PDF]
PLoS ONE, 2015 There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies.
Niklas K U Koehler +14 more
doaj +1 more source
Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]
, 2017 Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T +9 more
core +1 more source