Results 11 to 20 of about 659,948 (302)
Alpha synuclein and inflammaging
HeliyonThe α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Geneviève L. Putnam, Robert W. Maitta
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PLoS ONE, 2011 The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh +2 more
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Alpha synuclein in hematopoiesis and immunity
Heliyon, 2019 Parkinson's disease (PD) is the second most common neurodegenerative condition and intracellular deposition of Lewy bodies in the substantia nigra (SN), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. α-synuclein (syn) is a
Yu Pei, Robert W. Maitta
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Alpha-Synuclein to the Rescue: Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection [PDF]
Journal of Innate Immunity, 2017 Intraneuronal accumulation of misfolded alpha-synuclein in the central and peripheral nervous systems is strongly linked to Parkinson disease (PD) and other related synucleinopathies. In rare inherited forms of PD, point mutations or gene multiplications mediate the formation of alpha-synuclein protein aggregates.
Viviane, Labrie, Patrik, Brundin
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Microtubule depolymerization potentiates alpha-synuclein oligomerization
Frontiers in Aging Neuroscience, 2010 Parkinson’s disease (PD) is associated with perturbed mitochondria function and alpha-synuclein fibrillization. We evaluated potential mechanistic links between mitochondrial dysfunction and alpha-synuclein aggregation.
Russell H Swerdlow, Catarina Oliveira
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Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
Scientific Reports, 2022 Abstract Parkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the seeding effect of endocytosed alpha-synuclein (ASYN) on the endogenous ASYN. The appearance
Yanina Dening +16 more
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, 2019 Alpha-synuclein oligomers are thought to be toxic mediators of Parkinson's disease and other alpha-synucleinopathies, but their histological detection in situ in diseased brain has been a challenge in the field for some time. Here we describe a method, the alpha-synuclein proximity ligation assay (AS-PLA), to detect alpha-synuclein oligomers in ...
Roberts, RF +2 more
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The Membrane Interaction of Alpha-Synuclein [PDF]
Frontiers in Cellular Neuroscience, 2021 A presynaptic protein closely related to Parkinson's disease (PD), α-synuclein (α-Syn), has been studied extensively regarding its pathogenic mechanisms. As a physiological protein in presynapses, however, α-Syn's physiological function remains unclear.
Cencen Liu +7 more
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Protein and peptide letters, 2004 Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology.
Bodles, A.M., Irvine, Brent
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SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine [PDF]
Frontiers in Cellular Neuroscience, 2018 Methamphetamine (METH) is an illegal and widely abused psychoactive stimulant. METH abusers are at high risk of neurodegenerative disorders, including Parkinson's disease (PD). Previous studies have demonstrated that METH causes alpha-synuclein (α-syn) aggregation in the both laboratory animal and human.
Lin-nan Zhu +11 more
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