Results 61 to 70 of about 307,834 (316)

The immunology of neurodegeneration [PDF]

Journal of Clinical Investigation, 2012
While immune responses in neurodegeneration were regarded as little more than a curiosity a decade ago, they are now increasingly moving toward center stage. Factors driving this movement include the recognition that most of the relevant immune molecules are produced within the brain, that microglia are proficient immune cells shaping neuronal ...
Eva, Czirr, Tony, Wyss-Coray
openaire   +2 more sources

Dysregulated miR-124 mediates impaired social memory behavior caused by paternal early social isolation

Translational Psychiatry
Early social isolation (SI) leads to various abnormalities in emotion and behavior during adulthood. However, the negative impact of SI on offspring remains unclear.
Sijia Chen, Shixin Ding, Yingting Pang, Yuxi Jin, Peng Sun, Yue Li, Min Cao, Yimiao Wang, Ze Wang, Tianqi Wang, Ying Zou, Yanli Zhang, Ming Xiao   +12 more
doaj   +1 more source

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

Neurobiology of Disease, 2017
Proteinaceous inclusions in neurons, composed primarily of α-synuclein, define the pathology in several neurodegenerative disorders. Neurons can internalize α-synuclein fibrils that can seed new inclusions from endogenously expressed α-synuclein.
Hisham Abdelmotilib, Tyler Maltbie, Vedad Delic, Zhiyong Liu, Xianzhen Hu, Kyle B. Fraser, Mark S. Moehle, Lindsay Stoyka, Nadia Anabtawi, Valentina Krendelchtchikova, Laura A. Volpicelli-Daley, Andrew West   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Arhgef7 as a key target for enriched environment rescuing spatial cognitive deficits and anxiety-like behaviors in a mouse model of Alzheimer’s disease following early social isolation

Alzheimer’s Research & Therapy
Background Both social and physical environmental factors influence the progression of Alzheimer’s disease (AD), but the underlying mechanisms are not yet fully understood.
Yimiao Wang, Ze Wang, Yue Li, Min Cao, Shuying Zhang, Shixin Ding, Sijia Chen, Yuxi Jin, Yanli Zhang, Junying Gao, Ming Xiao   +10 more
doaj   +1 more source

Correction: Dominguez-Meijide et al. Pharmacological Modulators of Tau Aggregation and Spreading. Brain Sci. 2020, 10, 858

Brain Sciences
There was an error in the original publication [...]
Antonio Dominguez-Meijide, Eftychia Vasili, Tiago Fleming Outeiro   +2 more
doaj   +1 more source

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

Journal of Neuroinflammation, 2018
Background Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra.
Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu, Gang Hu   +8 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Chaperones in Neurodegeneration [PDF]

The Journal of Neuroscience, 2015
Cellular protein homeostasis (proteostasis) maintains the integrity of the proteome and includes protein synthesis, folding, oligomerization, and turnover; chaperone proteins assist with all of these processes. Neurons appear to be especially susceptible to failures in proteostasis, and this is now increasingly recognized as a major origin of ...
Lindberg, Iris, Shorter, James, Wiseman, R. Luke, CHITI, FABRIZIO, Dickey, Chad A, Mclean, Pamela J.   +5 more
openaire   +2 more sources

Insulin-incubated palladium clusters promote recovery after brain injury

Journal of Nanobiotechnology, 2022
Traumatic brain injury (TBI) is a cause of disability and death worldwide, but there are currently no specific treatments for this condition. Release of excess reactive oxygen species (ROS) in the injured brain leads to a series of pathological changes ...
Shengyang Fu, Shu Zhao, Huili Chen, Weitao Yang, Xiaohuan Xia, Xiaonan Xu, Zhanping Liang, Xuanran Feng, Zhuo Wang, Pu Ai, Lu Ding, Qingyuan Cai, Yi Wang, Yanyan Zhang, Jie Zhu, Bingbo Zhang, Jialin C. Zheng   +16 more
doaj   +1 more source