Results 61 to 70 of about 271,126 (314)

Correction: Dominguez-Meijide et al. Pharmacological Modulators of Tau Aggregation and Spreading. Brain Sci. 2020, 10, 858

Brain Sciences
There was an error in the original publication [...]
Antonio Dominguez-Meijide, Eftychia Vasili, Tiago Fleming Outeiro   +2 more
doaj   +1 more source

Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

Journal of Neuroinflammation, 2018
Background Parkinson’s disease (PD) is a neurodegenerative disorder with progressive loss of dopaminergic (DA) neurons. Systemic inflammation is shown to initiate and exacerbate DA neuronal degeneration in the substantia nigra.
Chen Qiao, Qian Zhang, Qingling Jiang, Ting Zhang, Miaomiao Chen, Yi Fan, Jianhua Ding, Ming Lu, Gang Hu   +8 more
doaj   +1 more source

Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson’s disease

npj Parkinson's Disease, 2021
Hyposmia is prodromal, and male sex is a risk marker for an enhanced likelihood ratio of Parkinson’s disease. The literature regarding olfactory bulb volume reduction is controversial, although the olfactory bulb has been largely reported as an early and
Alicia Flores-Cuadrado, Daniel Saiz-Sanchez, Alicia Mohedano-Moriano, Elena Lamas-Cenjor, Victor Leon-Olmo, Alino Martinez-Marcos, Isabel Ubeda-Bañon   +6 more
doaj   +1 more source

Sphingolipids in Neurodegeneration [PDF]

NeuroMolecular Medicine, 2010
Although the brain contains a high content of sphingolipids, we know relatively little about the roles that sphingolipids play in regulating neural functions. Once regarded only for their structural roles in maintaining the integrity of cellular and sub-cellular compartments, it is now apparent that many sphingolipid species are biologically active and
openaire   +2 more sources

Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay [PDF]

, 2015
BACKGROUND: Currently there are no effective treatments for many neurodegenerative diseases. Reliable biomarkers for identifying and stratifying these diseases will be important in the development of future novel therapies.
Zetterburg, H, J. M. Schott, Galimberti, D., Heales, S, Heywood, W. E., Bahtia, K, Schott, JM, E. Reid, Reid, E., Fox, N. C., A. Heslegrave, Hardy, J, Sirka, E., Hardy, J., Sebire, N. J., E. Scarpini, Zetterberg, Henrik,, Heslegrave, A., Mills, K., Fenoglio, C, Heales, S., D. Galimberti, S. Heales, Schott, J. M., Sebire, NJ, Heywood, WE, Scarpini, E., Fenoglio, C., Carecchio, M., M. Carecchio, Fox, NC, E. Sirka, N. C. Fox, W. E. Heywood, Mills, K, N. J. Sebire, C. Fenoglio, Bliss, E., J. Hardy, Galimberti, D, Paterson, RW, H. Zetterburg, Magdalinou, NK, Reid, E, Heslegrave, A, K. Bahtia, R. W. Paterson, Magdalinou, N. K., Bliss, E, Carecchio, M, Sirka, E, E. Bliss, N. K. Magdalinou, Bahtia, K., Scarpini, E, K. Mills, Paterson, R. W.   +56 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The epitranscriptomic m6A RNA modification modulates the synapse in ageing and in a mouse model of synucleinopathy

npj Parkinson's Disease
N6-methyladenosine (m6A) is the most abundant transcriptional modification in eukaryotic RNA, regulating RNA fate. While the functions of m6A in the development of the mammalian brain have been extensively studied, its role in synaptic plasticity, and ...
Avika Chopra, Mary Xylaki, Fanzheng Yin, Ricardo Castro-Hernández, Madiha Merghani, Valentina Grande, Brit Mollenhauer, André Fischer, Tiago F. Outeiro   +8 more
doaj   +1 more source

Evolution of Neurodegeneration [PDF]

Current Biology, 2012
A number of neurodegenerative diseases principally affect humans as they age and are characterized by the loss of specific groups of neurons in different brain regions. Although these disorders are generally sporadic, it is now clear that many of them have a substantial genetic component.
openaire   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic

Alzheimer’s Research & Therapy
Background Alzheimer’s disease (AD) is a common, complex and multifactorial disease that may require screening across multiple routes of referral to enable early detection and subsequent future implementation of tailored interventions.
Ilse Bader, Colin Groot, H. Stevie Tan, Jean-Marie A. Milongo, Jurre den Haan, Inge M. W. Verberk, Keir Yong, Julie Orellina, Shannon Campbell, David Wilson, Argonde C. van Harten, Pauline H. B. Kok, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Frederik Barkhof, Elsmarieke van de Giessen, Charlotte E. Teunissen, Femke H. Bouwman, Rik Ossenkoppele   +18 more
doaj   +1 more source