Results 11 to 20 of about 93,036 (258)
Mitochondrial Neurodegeneration [PDF]
Cells, 2022 Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the universal energy currency of the cell. This process is carried out by coupling electron stripping through oxidation of nutrient substrates with the formation of a proton-based electrochemical gradient across the inner mitochondrial membrane.
Zeviani, Massimo, Viscomi, Carlo
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Nanomaterials and neurodegeneration [PDF]
Environmental and Molecular Mutagenesis, 2015 The increasing application of nanotechnology in various industrial, environmental, and human settings raises questions surrounding the potential adverse effects induced by nanosized materials to human health, including the possible neurotoxic and neuroinflammatory properties of those substances and their capability to induce neurodegeneration.
MIGLIORE, LUCIA +3 more
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Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories. [PDF]
, 2016 Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C +7 more
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Mitochondria and Neurodegeneration
Bioscience Reports, 2007 Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in ...
PETROZZI, LUCIA +4 more
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, 2022 Wave V measures of neurodegeneration were based on venous blood collected via phlebotomy. The blood was collected by field examiners (FEs) certified in phlebotomy, chilled at 4°C during the remainder of the home exam, centrifuged immediately afterward ...
Whitsel, Eric A. +5 more
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Association of tear fluid amyloid and tau levels with disease severity and neurodegeneration
, 2021 There has been increasing interest in finding non-invasive biomarkers for neurodegenerative diseases such as Alzheimer’s disease (AD). This observational study investigated AD-specific biomarkers in tear fluid. Tear fluid was collected from a total of 65
Gijs, Marlies +7 more
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Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration [PDF]
, 2013 Microglia, the resident immune cells of the central nervous system (CNS), play an important role in CNS homeostasis during development, adulthood and ageing.
Perry, V. Hugh +3 more
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Deubiquitinases in Neurodegeneration [PDF]
Cells, 2022 Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly conserved among eukaryotes) to itself or to other proteins through differential use of ubiquitin’s seven internal linkage sites or the amino-terminal amino group. By creating different chain lengths, an enormous proteomic diversity may be formed.
Abudu I. Bello +7 more
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NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]
, 2014 There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L. +5 more
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Beyond the Primary Infarction: Focus on Mechanisms Related to Secondary Neurodegeneration after Stroke [PDF]
, 2022 Recently, a growing body of evidence has indicated that secondary neurodegeneration after stroke occurs at remote regions of the brain that are connected to the primary infarction site [...
Lin Kooi Ong, Ong, Lin Kooi
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