Results 11 to 20 of about 307,834 (316)
Microglia in neurodegeneration
Nature Neuroscience, 2018 The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century ago, are the main neuroimmune cells and have three essential functions: a sentinel function ...
S. Hickman +4 more
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Mitochondrial Neurodegeneration [PDF]
Cells, 2022 Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the universal energy currency of the cell. This process is carried out by coupling electron stripping through oxidation of nutrient substrates with the formation of a proton-based electrochemical gradient across the inner mitochondrial membrane.
Zeviani, Massimo, Viscomi, Carlo
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Nanomaterials and neurodegeneration [PDF]
Environmental and Molecular Mutagenesis, 2015 The increasing application of nanotechnology in various industrial, environmental, and human settings raises questions surrounding the potential adverse effects induced by nanosized materials to human health, including the possible neurotoxic and neuroinflammatory properties of those substances and their capability to induce neurodegeneration.
MIGLIORE, LUCIA +3 more
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Transglutaminases and neurodegeneration [PDF]
Journal of Neurochemistry, 2009 AbstractTransglutaminases (TGs) are Ca2+‐dependent enzymes that catalyze a variety of modifications of glutaminyl (Q) residues. In the brain, these modifications include the covalent attachment of a number of amine‐bearing compounds, including lysyl (K) residues and polyamines, which serve to either regulate enzyme activity or attach the TG substrates ...
Thomas M, Jeitner +4 more
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The Different Autophagy Degradation Pathways and Neurodegeneration
Neuron, 2022 The term autophagy encompasses different pathways that route cytoplasmic material to lysosomes for degradation and include macroautophagy, chaperone-mediated autophagy and microautophagy.
Angeleen Fleming +15 more
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Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies
Cells, 2021 The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis.
Inês C. Brás, Tiago F. Outeiro
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Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Translational Neurodegeneration, 2022 Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell death ...
M. Verma, Britney N. Lizama, C. Chu
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Deubiquitinases in Neurodegeneration [PDF]
Cells, 2022 Ubiquitination refers to the conjugation of the ubiquitin protein (a small protein highly conserved among eukaryotes) to itself or to other proteins through differential use of ubiquitin’s seven internal linkage sites or the amino-terminal amino group. By creating different chain lengths, an enormous proteomic diversity may be formed.
Abudu I. Bello +7 more
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Pharmacological Modulators of Tau Aggregation and Spreading
Brain Sciences, 2020 Tauopathies are neurodegenerative disorders characterized by the deposition of aggregates composed of abnormal tau protein in the brain. Additionally, misfolded forms of tau can propagate from cell to cell and throughout the brain.
Antonio Dominguez-Meijide +2 more
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Solving neurodegeneration: common mechanisms and strategies for new treatments
Molecular Neurodegeneration, 2022 Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology.
L. Wareham +20 more
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