Results 11 to 20 of about 300,100 (258)

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Ridler, CE, Pickering-Brown, Stuart, Norona, FE, Woollacott, I., Fratta, P., Norona, Frances E, Woollacott, IOC, Ridler, Charlotte E, Devoy, A, Pietrzyk, J, Fisher, EMC, Devoy, Anny, Dols, J, Dols, Jacqueline, Moens, T., Cleverley, K., Fratta, Pietro, Partridge, Linda, Nicoll, Andrew J, Fisher, E., Ridler, C., Fratta, P, Grönke, S., Pickering-Brown, S., Isaacs, Adrian M, Cabecinha, Melissa, Mizielinska, S, Moens, Thomas, Clayton, E., Partridge, L., Pietrzyk, J., Clayton, Emma L, Mizielinska, Sarah, Niccoli, T., Devoy, Anny; id_orcid, Mizielinska, Sarah; id_orcid, Isaacs, A., Woollacott, Ione O C, Cleverley, Karen, Nicoll, AJ, Hendrich, O., Moens, T, Dols, J., Grönke, Sebastian, Cabecinha, M., Cabecinha, M, Fisher, Elizabeth M C, Mizielinska, S., Clayton, EL, Nicoll, A., Hendrich, Oliver, Grönke, S, Niccoli, Teresa, Pietrzyk, Julian, Devoy, A., Norona, F., Isaacs, AM, Pickering-Brown, S, Cleverley, K, Hendrich, O, Niccoli, T, Partridge, L   +61 more
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Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration [PDF]

, 2013
Microglia, the resident immune cells of the central nervous system (CNS), play an important role in CNS homeostasis during development, adulthood and ageing.
Perry, V. Hugh, Teeling, Jessica, Jessica Teeling, V. Hugh Perry   +3 more
core   +1 more source

Anti-IgLON5 disease: relationship between neuroimmunology and neurodegeneration [PDF]

, 2022
Anti-IgLON5 disease is a rare autoimmune encephalitis (AE) with anti-IgLON5 antibodies in serum and/or CSF, which was first reported in 2014. Different from the traditional AE, anti-IgLON5 disease presents dual characteristics of neuroimmunity and ...
CHEN Sheng, ZHANG Yizongheng
core   +1 more source

Neurodegeneration and multiple sclerosis [PDF]

, 2018
Neurodegeneration causes inexorable loss of neurons and function in both diseases and aging. Neurodegeneration damage produces a range of progressive disabilities from cognitive decline, behavioral and mood disorders to problems with movement, co ...
Petzold, A
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NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE [PDF]

, 2014
There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L., James P. Fuller, Jeffrey B. Stavenhagen, Jessica L. Teeling, Stavenhagen, Jeffrey B., Fuller, James P.   +5 more
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High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci

Nature Communications, 2022
The genome-wide high-resolution chromatin contact of the human retina identifies genetic control of cell-type specific gene expression pattern, missing heritability in retinopathies, and candidate genes/variants for diseases including AMD and glaucoma.
Claire Marchal, Nivedita Singh, Zachary Batz, Jayshree Advani, Catherine Jaeger, Ximena Corso-Díaz, Anand Swaroop   +6 more
doaj   +1 more source

Relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging [PDF]

, 2020
Introduction: Studies have demonstrated a relationship between neurodegeneration and lifestyle factors. Neurodegeneration in midlife (40 – 59 years old) can be assessed using neuroimaging. The aim of the thesis was to evaluate the relationship between
Topiwala, Hinesh
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Striatal neuroinflammation promotes parkinsonism in rats [PDF]

, 2008
The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Randy L Hunter, Wayne Cass, Patrick G Sullivan, Pandya, Jignesh D., Dong-Young Choi, Don Gash, Patrick Sullivan, Hyoung-Chun Kim, Cass, Wayne A., Jignesh D Pandya, Hunter, Randy L., Don M Gash, Bing, Guoying, Randy Hunter, Eun-Joo Shin, Jignesh Pandya, Wayne A Cass, Gash, Don M., Sullivan, Patrick G., Choi, Dong-Young, Shin, Eun-Joo, Liu, Mei, Kim, Hyoung-Chun, Mei Liu, Guoying Bing, Bing Guoying, Hunter Randy L., Pandya Jignesh D., Choi Dong-Young, Liu Mei, Gash Don M., Sullivan Patrick G., Kim Hyoung-Chun, Cass Wayne A., Shin Eun-Joo   +34 more
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Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function

Acta Neuropathologica Communications, 2022
Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pathological protein aggregates that are ...
Rose B. Creed, Adeel A. Memon, Sindhu P. Komaragiri, Sandeep K. Barodia, Matthew S. Goldberg   +4 more
doaj   +1 more source

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease

Brain Sciences, 2023
Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels in the peripheral circulatory system of Parkinson’s disease (PD) patients.
Wei Quan, Chen-Meng Qiao, Gu-Yu Niu, Jian Wu, Li-Ping Zhao, Chun Cui, Wei-Jiang Zhao, Yan-Qin Shen   +7 more
doaj   +1 more source