Results 21 to 30 of about 271,126 (314)

Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function

Acta Neuropathologica Communications, 2022
Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pathological protein aggregates that are ...
Rose B. Creed, Adeel A. Memon, Sindhu P. Komaragiri, Sandeep K. Barodia, Matthew S. Goldberg   +4 more
doaj   +1 more source

Trimethylamine N-Oxide Exacerbates Neuroinflammation and Motor Dysfunction in an Acute MPTP Mice Model of Parkinson’s Disease

Brain Sciences, 2023
Observational studies have shown abnormal changes in trimethylamine N-oxide (TMAO) levels in the peripheral circulatory system of Parkinson’s disease (PD) patients.
Wei Quan, Chen-Meng Qiao, Gu-Yu Niu, Jian Wu, Li-Ping Zhao, Chun Cui, Wei-Jiang Zhao, Yan-Qin Shen   +7 more
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Relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging [PDF]

, 2020
Introduction: Studies have demonstrated a relationship between neurodegeneration and lifestyle factors. Neurodegeneration in midlife (40 – 59 years old) can be assessed using neuroimaging. The aim of the thesis was to evaluate the relationship between
Topiwala, Hinesh
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Impaired DNA damage response signaling by FUSNLS mutations leads to neurodegeneration and FUS aggregate formation [PDF]

, 2018
Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS.
Jochen H. Weishaupt, Maximilian Naujock, Böckers, Tobias M., Ludolph, Albert C., Petri, Susanne, Tobias M. Boeckers, Susanne Petri, René Günther, Vehlow, Anne, Lojewski, Xenia, Axel Freischmidt, Pal, Arun, Weis, Joachim, Stanslowsky, Nancy, Freischmidt, Axel, Anand Goswami, Sterneckert, Jared, Jared Sterneckert, Peter Reinhardt, Julia Japtok, Poser, Ina, Troost, Dirk, Grill, Stephan W., Hermann, Andreas, Dirk Troost, Pan-Montojo, Francisco, Naujock, Maximilian, Anne Vehlow, Goswami, Anand, Liebau, Stefan, Alexander Storch, Günther, René, Jin, Mengmeng, Marcel Naumann, Marie Frickenhaus, Karlheinz Holzmann, Reinhardt, Peter, Stephan W. Grill, Nancy Stanslowsky, Florian Wegner, Storch, Alexander, Francisco Pan-Montojo, Ina Poser, Stefan Liebau, Holzmann, Karlheinz, Joachim Weis, Frickenhaus, Marie, Storkebaum, Erik, Albert C. Ludolph, Boeckers, Tobias M., Hyman, Anthony A., Andreas Hermann, Cordes, Nils, Naumann, Marcel, Japtok, Julia, Nils Cordes, Weishaupt, Jochen H., Erik Storkebaum, Anthony A. Hyman, Wegner, Florian, Arun Pal, Xenia Lojewski, Mengmeng Jin   +62 more
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Neurodegeneration

, 2022
Wave V measures of neurodegeneration were based on venous blood collected via phlebotomy. The blood was collected by field examiners (FEs) certified in phlebotomy, chilled at 4°C during the remainder of the home exam, centrifuged immediately afterward ...
Whitsel, Eric A., O'Hara, Rick, Harris, Kathleen Mullan, Qu, Lixin, Angel, Robert, Carrier, Kathryn   +5 more
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Insights into molecular mechanisms of disease in Neurodegeneration with Brain Iron Accumulation; unifying theories.

, 2016
Neurodegeneration with brain iron accumulation (NBIA) is a group of disorders characterised by dystonia, parkinsonism and spasticity. Iron accumulates in the basal ganglia and may be accompanied by Lewy bodies, axonal swellings and hyperphosphorylated ...
Arber, C, Houlden, H, H. Houlden, C. E. Arber, S. Wray, Wray, S, A. Li, Li, A   +7 more
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14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model

Acta Neuropathologica Communications, 2021
Alpha-synuclein (αsyn) is the key component of proteinaceous aggregates termed Lewy Bodies that pathologically define a group of disorders known as synucleinopathies, including Parkinson’s Disease (PD) and Dementia with Lewy Bodies.
Rachel Underwood, Mary Gannon, Aneesh Pathak, Navya Kapa, Sidhanth Chandra, Alyssa Klop, Talene A. Yacoubian   +6 more
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Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection

, 2019
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.

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The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

Molecular Medicine, 2023
Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration.
Ricardo Sant’Anna, Bruno K. Robbs, Júlia Araújo de Freitas, Patrícia Pires dos Santos, Annekatrin König, Tiago Fleming Outeiro, Debora Foguel   +6 more
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NEW ROLES FOR FC RECEPTORS IN NEURODEGENERATION-THE IMPACT ON IMMUNOTHERAPY FOR ALZHEIMER’S DISEASE

, 2014
There are an estimated 18 million Alzheimer’s disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Teeling, Jessica L., James P. Fuller, Jeffrey B. Stavenhagen, Jessica L. Teeling, Stavenhagen, Jeffrey B., Fuller, James P.   +5 more
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