Results 21 to 30 of about 300,100 (258)

The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis

Molecular Medicine, 2023
Background Soluble oligomeric forms of alpha-synuclein (aSyn-O) are believed to be one of the main toxic species in Parkinson’s disease (PD) leading to degeneration.
Ricardo Sant’Anna, Bruno K. Robbs, Júlia Araújo de Freitas, Patrícia Pires dos Santos, Annekatrin König, Tiago Fleming Outeiro, Debora Foguel   +6 more
doaj   +1 more source

AMPK-autophagy-mediated inhibition of microRNA-30a-5p alleviates morphine tolerance via SOCS3-dependent neuroinflammation suppression

Journal of Neuroinflammation, 2022
Background The development of morphine tolerance is a clinical challenge for managing severe pain. Studies have shown that neuroinflammation is a critical aspect for the development of analgesic tolerance.
Li Wan, Ru-Meng Jia, Lu-Lu Ji, Xin-Miao Qin, Liang Hu, Fan Hu, Yuan Han, Yin-Bing Pan, Chun-Yi Jiang, Wen-Tao Liu   +9 more
doaj   +1 more source

Zoom in on neurodegeneration [PDF]

, 2006
Despite the existence of several scientific journals that publish research papers and reviews related to neurodegenerative diseases, a journal specifically devoted to the molecular and cellular aspects of disease mechanisms is lacking.
Huaxi, Xu, Bu, Guojun, Golde, Todd E., Huaxi Xu, Xu Huaxi, Guojun, Bu, Bu Guojun, Guojun Bu, Golde Todd E, Xu, Huaxi, Golde, Todd E, Todd E Golde   +11 more
core   +1 more source

Behavioral defects associated with amygdala and cortical dysfunction in mice with seeded α-synuclein inclusions

Neurobiology of Disease, 2020
Parkinson's disease (PD) is defined by motor symptoms such as tremor at rest, bradykinesia, postural instability, and stiffness. In addition to the classical motor defects that define PD, up to 80% of patients experience cognitive changes and psychiatric
Lindsay E. Stoyka, Andrew E. Arrant, Drake R. Thrasher, Dreson L. Russell, Jennifer Freire, Casey L. Mahoney, Ashwin Narayanan, Aseel G. Dib, David G. Standaert, Laura A. Volpicelli-Daley   +9 more
doaj   +1 more source

Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons

Molecular Brain, 2021
Rho-associated kinase isoform 2 (ROCK2) is an attractive drug target for several neurologic disorders. A critical barrier to ROCK2-based research and therapeutics is the lack of a mouse model that enables investigation of ROCK2 with spatial and temporal ...
Audrey J. Weber, Ashley B. Adamson, Kelsey M. Greathouse, Julia P. Andrade, Cameron D. Freeman, Jung Vin Seo, Rosaria J. Rae, Courtney K. Walker, Jeremy H. Herskowitz   +8 more
doaj   +1 more source

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

Molecular Neurodegeneration, 2022
Background Leucine rich repeat kinase 2 (LRRK2) and SNCA are genetically linked to late-onset Parkinson’s disease (PD). Aggregated α-synuclein pathologically defines PD.
Enquan Xu, Ravindra Boddu, Hisham A. Abdelmotilib, Arpine Sokratian, Kaela Kelly, Zhiyong Liu, Nicole Bryant, Sidhanth Chandra, Samantha M. Carlisle, Elliot J. Lefkowitz, Ashley S. Harms, Etty N. Benveniste, Talene A. Yacoubian, Laura A. Volpicelli-Daley, David G. Standaert, Andrew B. West   +15 more
doaj   +1 more source

Microglia inhibit astrocyte-mediated neurodegeneration [PDF]

, 2020
Prion diseases are infectious protein-misfolding disorders associated with neurodegeneration and glial activation in the CNS. Microglia have been suggested to play a critical role during prion disease.
Bradford, Barry; id_orcid, Hume, David A., Mabbott, Neil; id_orcid, Pridans, Clare; id_orcid   +3 more
core   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A manifesto for Alzheimer’s disease drug discovery in the era of disease-modifying therapies

Molecular Neurodegeneration
After decades of disappointment, three disease-modifying therapies for Alzheimer’s disease (AD) have been approved since 2021. Burgeoning clinical data on these amyloid β-protein (Aβ) targeting drugs validate the amyloid cascade hypothesis as a molecular
Heike Hering, Thierry Bussiere, Chia-Chen Liu, Kelly E. Glajch, Andreas Weihofen, Jane Grogan, Dominic M. Walsh   +6 more
doaj   +1 more source

Stress granules formation in HEI-OC1 auditory cells and in H4 human neuroglioma cells secondary to cisplatin exposure

Cell Stress
Stress granules (SGs) are highly dynamic micromolecular membraneless condensates that generate in cells subjected to stress. Formed from pools of untranslating messenger ribonucleoproteins (RNP), SGs dynamics constitute vital processes essential for cell
Hebatallah Abdelrasol, Avika Chopra, Liana Shvachiy, Dirk Beutner, Tiago F Outeiro, Cristian Setz   +5 more
doaj   +1 more source