Results 21 to 30 of about 93,036 (258)

Chronochemistry in neurodegeneration [PDF]

Frontiers in Molecular Neuroscience, 2014
The problem of distinguishing causes from effects is not a trivial one, as illustrated by the science fiction writer Isaac Asimov in a novel dedicated to an imaginary compound with surprising "chronochemistry" properties. The problem is particularly important when trying to establish the etiology of diseases.
Pastore Annalisa, Adinolfi Salvatore
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C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Ridler, CE, Pickering-Brown, Stuart, Norona, FE, Woollacott, I., Fratta, P., Norona, Frances E, Woollacott, IOC, Ridler, Charlotte E, Devoy, A, Pietrzyk, J, Fisher, EMC, Devoy, Anny, Dols, J, Dols, Jacqueline, Moens, T., Cleverley, K., Fratta, Pietro, Partridge, Linda, Nicoll, Andrew J, Fisher, E., Ridler, C., Fratta, P, Grönke, S., Pickering-Brown, S., Isaacs, Adrian M, Cabecinha, Melissa, Mizielinska, S, Moens, Thomas, Clayton, E., Partridge, L., Pietrzyk, J., Clayton, Emma L, Mizielinska, Sarah, Niccoli, T., Devoy, Anny; id_orcid, Mizielinska, Sarah; id_orcid, Isaacs, A., Woollacott, Ione O C, Cleverley, Karen, Nicoll, AJ, Hendrich, O., Moens, T, Dols, J., Grönke, Sebastian, Cabecinha, M., Cabecinha, M, Fisher, Elizabeth M C, Mizielinska, S., Clayton, EL, Nicoll, A., Hendrich, Oliver, Grönke, S, Niccoli, Teresa, Pietrzyk, Julian, Devoy, A., Norona, F., Isaacs, AM, Pickering-Brown, S, Cleverley, K, Hendrich, O, Niccoli, T, Partridge, L   +61 more
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Transglutaminases and neurodegeneration [PDF]

Journal of Neurochemistry, 2009
AbstractTransglutaminases (TGs) are Ca2+‐dependent enzymes that catalyze a variety of modifications of glutaminyl (Q) residues. In the brain, these modifications include the covalent attachment of a number of amine‐bearing compounds, including lysyl (K) residues and polyamines, which serve to either regulate enzyme activity or attach the TG substrates ...
Thomas M, Jeitner, John T, Pinto, Boris F, Krasnikov, Mark, Horswill, Arthur J L, Cooper   +4 more
openaire   +2 more sources

Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration [PDF]

, 2013
Background Epidemiological and molecular findings suggest a relationship between Alzheimer’s disease (AD) and dyslipidemia, although the nature of this association is not well understood ...
McEvoy, LK, Blennow, Kaj,, Brewer, JB, Zetterberg, H, Desikan, RS, Zetterberg, Henrik,, Zetterberg, Henrik, Andreassen, Ole A, Hyman, Bradley T, Holland, Dominic, Desikan, Rahul S, Thompson, Wesley K, Dale, Anders M, Dale, AM, Hess, CP, Blennow, K, Hyman, BT, Brewer, James B, Thompson, WK, Holland, D, Andreassen, OA, Blennow, Kaj, McEvoy, Linda K, Hess, Christopher P   +23 more
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Tau and neurodegeneration

Cytoskeleton, 2023
AbstractFirst identified in 1975, tau was implicated in Alzheimer's disease 10 years later. Filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. In 1998, mutations in MAPT, the gene that encodes tau, were identified
Goedert, Michel, Crowther, R Anthony, Scheres, Sjors HW, Spillantini, Maria Grazia   +3 more
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Neurodegeneration: New Road Leads Back to the Synapse [PDF]

, 2012
Much of Parkinson’s research over the last decade has focused on cellular stress as a candidate mechanism. In this issue of Neuron, a new study by Matta et al.
Heutink, Peter, Verhage, Matthijs, Heutink, P., Verhage, M.   +3 more
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Ecstasy and neurodegeneration [PDF]

BMJ, 1996
Publicity in the popular press and medical journals1 on the dangers of using ecstasy (3,4-methylenedioxymethamphetamine) has concentrated almost exclusively on the problems of acute toxicity. While the unnecessary death of any young person is rightly deplored, it is strange that so little attention is being paid to the long term effects of this ...
A R, Green, G M, Goodwin
openaire   +2 more sources

Striatal neuroinflammation promotes parkinsonism in rats [PDF]

, 2008
The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Randy L Hunter, Wayne Cass, Patrick G Sullivan, Pandya, Jignesh D., Dong-Young Choi, Don Gash, Patrick Sullivan, Hyoung-Chun Kim, Cass, Wayne A., Jignesh D Pandya, Hunter, Randy L., Don M Gash, Bing, Guoying, Randy Hunter, Eun-Joo Shin, Jignesh Pandya, Wayne A Cass, Gash, Don M., Sullivan, Patrick G., Choi, Dong-Young, Shin, Eun-Joo, Liu, Mei, Kim, Hyoung-Chun, Mei Liu, Guoying Bing   +24 more
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Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition

, 2022
Background: Glial fibrillary acidic protein (GFAP) is a promising candidate blood-based biomarker for Alzheimer's disease (AD) diagnosis and prognostication.

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Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

, 2021
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue ...
Roth, Vanessa, Schwencke-Westphal, Celina, Schubert, Charlotte, Bal, Lukas Can, Witte, Maarten E., Pless, Ole, Rosenkranz, Sina C., Vieira, Vanessa, Bauer, Simone, Shaposhnykov, Artem A., van Horssen, Jack, Friese, Manuel A., Schattling, Benjamin, Paauw, Nanne, Traeger, Simone, Freichel, Marc, Engler, Jan Broder   +16 more
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