Results 21 to 30 of about 307,834 (316)

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

Acta Neuropathologica Communications, 2021
Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological ...
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao   +15 more
doaj   +1 more source

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

Lancet Neurology, 2013
Summary Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can
J. Wardlaw, Eric E. Smith, G. Biessels, C. Cordonnier, F. Fazekas, R. Frayne, R. Lindley, J. O'Brien, F. Barkhof, O. Benavente, S. Black, C. Brayne, M. Breteler, H. Chabriat, C. DeCarli, F. de Leeuw, F. Doubal, Marco Duering, Nick C Fox, S. Greenberg, V. Hachinski, I. Kilimann, V. Mok, R. V. Oostenbrugge, L. Pantoni, O. Speck, B. Stephan, S. Teipel, A. Viswanathan, D. Werring, C. Chen, Colin Smith, M. van Buchem, B. Norrving, P. Gorelick, M. Dichgans   +35 more
semanticscholar   +1 more source

Mitochondria and Neurodegeneration

Bioscience Reports, 2007
Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in ...
PETROZZI, LUCIA, RICCI G, GIGLIOLI NJ, SICILIANO, GABRIELE, MANCUSO, MICHELANGELO   +4 more
openaire   +3 more sources

The blood-brain barrier in aging and neurodegeneration

Molecular Psychiatry, 2022
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma.
Emily G. Knox, M. R. Aburto, G. Clarke, J. Cryan, C. O’Driscoll   +4 more
semanticscholar   +1 more source

Circadian disruption and sleep disorders in neurodegeneration

Translational Neurodegeneration, 2023
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and ...
Yun Shen, Qian-kun Lv, W. Xie, Siming Gong, Zhuang Sheng, Jun-yi Liu, C. Mao, Chun-feng Liu   +7 more
semanticscholar   +1 more source

Microglia Function in the Central Nervous System During Health and Neurodegeneration

Annual Review of Immunology, 2017
Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct from other tissue macrophages owing to their unique homeostatic ...
M. Colonna, O. Butovsky
semanticscholar   +1 more source

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Journal of Neuroscience, 2006
Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD).
Holly Oakley, Sarah L. Cole, Sreemathi Logan, E. Maus, Peizhen Shao, J. Craft, Angela L. Guillozet-Bongaarts, M. Ohno, J. Disterhoft, Linda J Van Eldik, R. Berry, R. Vassar   +11 more
semanticscholar   +1 more source

Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

Journal of Experimental Medicine, 2022
Tau present in the extracellular fluids has a critical role in the pathogenesis of tauopathies. The authors describe that glymphatic clearance of extracellular tau impacts tau accumulation and neurodegeneration.
K. Ishida, Kaoru Yamada, R. Nishiyama, T. Hashimoto, Itaru Nishida, Yoichiro Abe, Masato Yasui, T. Iwatsubo   +7 more
semanticscholar   +1 more source

Metals and Neurodegeneration [PDF]

F1000Research, 2016
Metals play important roles in the human body, maintaining cell structure and regulating gene expression, neurotransmission, and antioxidant response, to name a few. However, excessive metal accumulation in the nervous system may be toxic, inducing oxidative stress, disrupting mitochondrial function, and impairing the activity of numerous enzymes ...
Pan Chen, Mahfuzur Rahman Miah, Michael Aschner   +2 more
openaire   +2 more sources

High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci

Nature Communications, 2022
The genome-wide high-resolution chromatin contact of the human retina identifies genetic control of cell-type specific gene expression pattern, missing heritability in retinopathies, and candidate genes/variants for diseases including AMD and glaucoma.
Claire Marchal, Nivedita Singh, Zachary Batz, Jayshree Advani, Catherine Jaeger, Ximena Corso-Díaz, Anand Swaroop   +6 more
doaj   +1 more source