Open Biology, 2023 Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Athanasios K Anagnostopoulos +2 more
exaly +3 more sources
Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. [PDF]
PLoS ONE, 2015 Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons of the substantia nigra. The hallmark of PD is the appearance of neuronal protein aggregations known as Lewy bodies and Lewy neurites, of which α ...
Warunee Dansithong +4 more
doaj +2 more sources
Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review. [PDF]
Mov Disord Clin PractAbstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Meneghini C +5 more
europepmc +2 more sources
Prognostic significance of SNCA and its methylation in bladder cancer
BMC Cancer, 2022 Background The epidemiological investigation of different cancer types in the global population has reported a decreased risk of bladder cancer (BLCA) in Parkinson’s diseases (PD).
Zhengcun Wu +4 more
doaj +3 more sources
Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines. [PDF]
Brain PatholOmics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Cartas-Cejudo P +7 more
europepmc +2 more sources
Expanded Hepatic Progenitor Cells Featured with Aggregation of α-Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia. [PDF]
Adv Sci (Weinh)Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Xie H +12 more
europepmc +2 more sources
Assessment of Mitochondrial Gene Activity in Dopaminergic Neuron Cultures Derived from Induced Pluripotent Stem Cells Obtained from Parkinson's Disease Patients [PDF]
Анналы клинической и экспериментальной неврологии, 2023 Introduction. Induced pluripotent stem cells (iPSCs) culturing allows modelling of neurodegenerative diseases in vitro and discovering its early biomarkers.
Anna S. Vetchinova +3 more
doaj +1 more source
Exploration of Neuroprotective Therapy, 2023 Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)].
Bianca Vlcek +5 more
doaj +1 more source
SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma
BMC Cancer, 2022 Background The SNCA gene is a critical gene in Parkinson’s disease (PD) pathology. Accumulating evidence indicates that SNCA is involved in tumorigenesis; however, the role of SNCA in lung adenocarcinoma (LUAD) remains unclear.
Xiuao Zhang, Zhengcun Wu, Kaili Ma
doaj +1 more source
Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. [PDF]
PLoS ONE, 2009 Genetic variability across the SNCA locus has been repeatedly associated with susceptibility to sporadic Parkinson's disease (PD). Accumulated evidence emphasizes the importance of SNCA dosage and expression levels in PD pathogenesis.
Colton Linnertz +8 more
doaj +1 more source