Results 31 to 40 of about 15,713 (203)

Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen

Scientific Reports, 2021
Multiplications, mutations and dysregulation of the alpha synuclein gene (SNCA) are associated with the demise of dopaminergic neurons and are considered to play important roles in the pathogenesis of familial and sporadic forms of Parkinson’s disease ...
Fabian Stahl, Philip Denner, Dominik Piston, Bernd O. Evert, Laura de Boni, Ina Schmitt, Peter Breuer, Ullrich Wüllner   +7 more
doaj   +1 more source

Evidence of a role for SNCA in impulse control in humans [PDF]

neurogenetics, 2013
Alpha-synuclein has been implicated in impulsivity in mice [1] and in addictive behavior (suggestive of impaired impulse control) in both rodents and humans [1, 2]; therefore, the α-synuclein gene (SNCA) may influence the development of impulsivity in humans, although to date no study has examined this relationship.
Casey R, Guillot, Jennifer R, Fanning, Tiebing, Liang, Mitchell E, Berman   +3 more
openaire   +2 more sources

Implications for alpha-synuclein antisense transcript SNCA-AS1 in Parkinson’s Disease: role in synaptogenesis and aging-related pathways [PDF]

, 2021
SNCA protein product, alpha-synuclein, is widely renowned for its role in synaptogenesis and implication in both aging and Parkinson’s Disease, but research efforts are still needed to elucidate its physiological functions and regulation.
Cecilia Pandini, Gian Vincenzo Zuccotti, Federica Rey, Roberta Zangaglia, Letizia Messa, Cristina Cereda, Stella Gagliardi, Stefana Carelli, Rossella Launi   +8 more
core   +2 more sources

Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson’s disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007)

Stem Cell Research, 2021
Mutations in the SNCA (α-synuclein, PARK1) gene significantly contribute to Parkinson’s disease and SNCA inclusions are strongly associated with PD. Fibroblasts from a 51-year-old female patient with disease onset at 39 years, carrying the A53T SNCA ...
Gabriela Novak, Steven Finkbeiner, Gaia Skibinski, Alexander Skupin   +3 more
doaj   +1 more source

Isogenic human SNCA gene dosage induced pluripotent stem cells to model Parkinson’s disease

Stem Cell Research, 2022
Alpha-synuclein overexpression and aggregation are critical factors in the pathogenesis of Parkinson’s disease (PD). Clinical cases with alpha-synuclein (SNCA) multiplications or deletions indicate that gene expression levels are essential for ...
Faria Zafar, Vasavi Nallur Srinivasaraghavan, Max Yang Chen, C. Alejandra Morato Torres, Birgitt Schüle   +4 more
doaj   +1 more source

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

, 2014
\ua9 2014 Taylor & Francis Group, LLC. SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating SNCA species are degraded by the autophagy-lysosomal
Meixner H, Poehler A-M, Rockenstein E, Spitzer P, Chutna O, Winkler J, Outeiro TF, Klucken J, Xiang W, May VEL, Masliah E   +10 more
core   +4 more sources

Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients and healthy controls.

Frontiers in Aging Neuroscience, 2014
Alpha-synuclein (Snca) plays a major role in Parkinson Disease (PD). Circulating anti-Snca antibodies have been described in PD patients and healthy controls, but they have been poorly characterized.
Beatriz eAlvarez-Castelao, Ana eGorostidi, Javier eRuiz-Martinez, Adolfo eLópez de Munain, Jose G Castaño   +4 more
doaj   +1 more source

Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation

Stem Cell Research, 2018
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. PD can result from a mutation of alpha-synuclein (α-SNCA), such as α-SNCA A53T.
Seo-Young Lee, SangKyun Jeong, Janghwan Kim, Sun-Ku Chung   +3 more
doaj   +1 more source

Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy Brains

Frontiers in Neuroscience, 2021
Parkinson’s disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. SNCA gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of ...
Jeffrey Gu, Jeffrey Gu, Julio Barrera, Julio Barrera, Young Yun, Young Yun, Susan K. Murphy, Thomas G. Beach, Randy L. Woltjer, Geidy E. Serrano, Boris Kantor, Boris Kantor, Ornit Chiba-Falek, Ornit Chiba-Falek   +13 more
doaj   +1 more source

A protocol for the study of environmental risk factors and candidate gene–environment interactions in neurodegenerative disorders in Nigeria (SERGEND): A cross-sectional descriptive study

Journal of Clinical Sciences
Introduction: The risk of developing neurodegenerative disorders (NDDs) such as Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease and atypical parkinsonism (PDAP), has been alluded to arise predominantly from the interplay between ...
Oluwadamilola Omolara Ojo, Osigwe P Agabi, Ismail O Ishola, Olajumoke O Oshinaike, Sani A Abubakar, Kolawole W Wahab, Abiodun H Bello, Rufus O Akinyemi, Uduak Williams, Simon I Ozomma, Oluchi Ekenze, Emmanuel Iwuozo, Yakub W Nyandaiti, Francis I Ojini, Henry Houlden, John Hardy, Njideka Ulunma Okubadejo   +16 more
doaj   +1 more source