Results 21 to 30 of about 15,713 (203)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation [PDF]

Acta Naturae, 2020
Neurodegeneration in Parkinsons disease is characterized by the accumulation of alpha-synuclein, aprotein encoded by theSNCAgene, in neurons. In addition to mutations, many polymorphisms have been identified in this gene, and one of theseis a dinucleotide microsatellite:SNCA-Rep1.The mechanisms by which specific configurations ofSNCA-Rep1 may ...
Iakovenko, E. V., Abramycheva, N. Yu., Fedotova, E. Yu., Illarioshkin, S. N.   +3 more
openaire   +2 more sources

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated mutation of the SNCA gene [PDF]

, 2020
An experimental treatment for Parkinson’s disease (PD) involved the transplantation of fetal midbrain tissue, a source of midbrain dopaminergic (mDA) progenitors, into the striatum of patients to restore dopaminergic innervation.
Chen, Yixi
core   +1 more source

CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. [PDF]

PLoS ONE, 2010
BACKGROUND: Alpha-synuclein (SNCA) gene expression is an important factor in the pathogenesis of Parkinson's disease (PD). Gene multiplication can cause inherited PD, and promoter polymorphisms that increase SNCA expression are associated with sporadic ...
Lumine Matsumoto, Hiroshi Takuma, Akira Tamaoka, Hiroshi Kurisaki, Hidetoshi Date, Shoji Tsuji, Atsushi Iwata   +6 more
doaj   +1 more source

SNCA-AS1, antisense transcript to the SNCA gene, regulates alpha-synuclein and synaptic modulation with possible implications in Parkinson’s Disease and aging. [PDF]

, 2023
Background/Objectives: SNCA protein product, alpha-synuclein (alpha-syn), is widely renowned for its role in synaptogenesis and implication in both Parkinson’s Disease (PD) and aging, but research efforts are needed to clarify its physiological functions.
Esposito L., Zuccotti GV., Pandini C., Rey F., Maghraby E., Messa L., Carelli S. Cereda C.   +6 more
core   +1 more source

DNA methylation in Parkinson disease

Анналы клинической и экспериментальной неврологии, 2020
Parkinson disease (PD) is one of the most widespread neurodegenerative diseases in the elderly. It causes motor impairment and the development of non-motor symptoms, which reduce the quality of life and gradually lead to patient disability.
Elena V. Yakovenko, Ekaterina Yu. Fedotova, Sergey N. Illarioshkin   +2 more
doaj   +1 more source

α-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease [alpha-Synuclein antisense transcript SNCA-AS1 regulates synapses- and aging-related genes suggesting its implication in Parkinson's disease] [PDF]

, 2021
SNCA protein product, α-synuclein, is widely renowned for its role in synaptogenesis and implication in both aging and Parkinson's disease (PD), but research efforts are still needed to elucidate its physiological functions and mechanisms of regulation ...
Gagliardi S., Pandini C., Cereda C., Rey F., Messa L., Zangaglia R., Launi R., Barzaghini B., Carelli S., Raimondi M. T., Zuccotti G. V.   +10 more
core   +2 more sources

Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

Cells, 2020
Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk
Chien-Tai Hong, Kai-Yun Chen, Weu Wang, Jing-Yuan Chiu, Dean Wu, Tsu-Yi Chao, Chaur-Jong Hu, Kai-Yin David Chau, Oluwaseun Adebayo Bamodu   +8 more
doaj   +1 more source

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. [PDF]

, 2010
We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS.
R. A. Barker, Z. Su, Spencer, C.C.A., Pearson, Justin P., McCarthy, Mark I, Wellcome Trust Case Control Consortium 2, Sawcer, SJ, Craddock, Nicholas John, Markus, Hugh S, Viswanathan, Ananth C., L. Peltonen, Potter, S, Rautanen, A, Gray, E, Hardy, J., Donnelly, P., Casas, J.-P., V. Plagnol, Deloukas, P, CORVIN, AIDEN PETER, Langford, C., Sawcer, Stephen J, Peltonen, L, Jankowski, J., Palmer, Colin N. A., E. Bramon, Edkins, Sarah, M. I. McCarthy, Peltonen, L., null null, G. Band, Craddock, Nicholas, Hudson, Gavin, Gray, E., Palmer, CN, Morrison, KE, Su, Zhan, Evans, Jonathan, Corvin, A, Viswanathan, A.C., A. C. Viswanathan, Morrison, Karen, Mathew, Christopher G.; id_orcid, Palmer, Colin NA, Spencer, C. C., Donnelly, P, Evans, J, Morrison, K.E.; id_orcid, Hunt, S., Palmer, C.N.A., Wood, Nicholas W., Craddock, N, Brown, Martin A., Hunt, S, H. Blackburn, A. Strange, D. Burn, J. Evans, Corvin, A., P. Donnelly, Gardner, M, Chinnery, Patrick F., Palmer, C. N., Burn, D, A. J. Lees, Bramon, E, Potter, Simon, Pirinen, Matti, Trembath, Richard C, Plagnol, V., Hardy, John, McCarthy, M. I., J. P. Pearson, Morris, H. R., C. Freeman, Edkins, S., Clarke, Carl E, Blackburn, Hannah, Morris, H.R., Clarke, Carl; id_orcid, Plagnol, V, Trembath, RC, Bhatia, Kailash, Langford, C, Gardner, M., S. Edkins, Viswanathan, A. C., Peltonen, Leena, Burn, D., R. C. Trembath, Sawcer, Stephen J., K. Bhatia, C. Langford, McCarthy, MI, Spencer, Chris CA, Spencer, Chris, Strange, Amy, C. C. A. Spencer, Bellenguez, C., J. Jankowski, Freeman, C., Brown, M. A., Spencer, Chris C.A., Bhatia, K., Langford, Cordelia, Wood, NW, Barker, R. A., Freeman, Colin, Chinnery, PF, Hunt, Sarah, Clarke, Carl E., C. E. Clarke, Markus, HS, Lees, A. J., Spencer, Chris C. A., P. F. Chinnery, Gray, Emma, Chinnery, P. F., Morris, Huw R., H. R. Morris, Paisan-Ruiz, C., Clarke, C.E., McCarthy, Mark I., Brown, MA, Blackburn, H., Wood, N.W., Clarke, CE, Gardner, Michelle, Plagnol, Vincent, S. Potter, A. Rautanen, Wood, N. W., Pearson, JP, Hardy, J, Evans, J., Morrison, K. E., Morrison, Karen E., Mathew, CG, Donnelly, Peter, C. Paisan-Ruiz, Chinnery, P.F., Pirinen, M., Lees, A.J., A. Corvin, Mathew, Christopher G, Su, Z., Edkins, S, Craddock, N., Brown, Martin A, Morris, Huw Rees, Trembath, Richard C., Wood, Nicholas W, Pirinen, M, Viswanathan, Ananth C, Clarke, C. E., Burn, David, Barker, Roger A, Strange, A., Blackwell, JM, Casas, J. P., C. G. Mathew, Williams, Nigel W, Paisan-Ruiz, C, Lees, AJ, P. Deloukas, N. W. Williams, C. Bellenguez, UK Parkinson's Disease Consortium, Deloukas, P., Mathew, C. G., G. Hudson, Su, Z, Plomin, R., Spencer, Chris C A, N. W. Wood, Plomin, R, S. Hunt, Morris, Huw R, Casas, Juan-Pablo, Barker, Roger A., Barker, Roger, Brown, Matthew A, Casas, JP, Barker, R.A., Rautanen, Anna, Bramon, Elvira, Plomin, Robert, Jankowski, Janusz, Band, G., McCarthy, M.I., Freeman, C, M. A. Brown, Bhatia, K, Brown, M. A, Sawcer, S.J., J. M. Blackwell, H. S. Markus, M. Gardner, Lees, Andrew J, Morris, HR, Band, Gavin, Strange, A, Brown, Matthew A., Markus, H.S., Blackburn, H, Paisan-Ruiz, Coro, Rautanen, A., Williams, Nigel W., Williams, N.W., Pearson, Justin P, C. N. A. Palmer, Blackwell, J. M., Deloukas, Panos, Bellenguez, Celine, Williams, N. W., Morrison, K.E., S. J. Sawcer, Brown, M.A., Bramon, E., Trembath, R. C., Barker, RA, Spencer, CC, Blackwell, Jennie M, Chinnery, Patrick F, Blackwell, Jennie M., Hudson, G, Spencer, C. C. A., Markus, Hugh S., N. Craddock, Morrison, Karen E, Lees, Andrew J., Band, G, Palmer, Colin N A; id_orcid, Jankowski, J, Blackwell, J.M., K. E. Morrison, Hudson, G., E. Gray, Viswanathan, AC, Potter, S., Palmer, C. N. A., Mathew, C.G., Williams, NW, J.-P. Casas, Bellenguez, C, J. Hardy, Williams, Nigel Melville, Pearson, J.P., R. Plomin, Pearson, J. P., Corvin, Aiden, Sawcer, S. J., M. Pirinen, Trembath, R.C., Markus, H. S.   +254 more
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Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region [PDF]

Open Biology, 2016
Genetic and biochemical studies have established a central role for α-synuclein (SNCA) accumulation in the pathogenesis of Parkinson's disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one ...
Pelagia Koukouraki, Epaminondas Doxakis   +1 more
doaj   +1 more source

Rationale for Therapeutic Silencing of Alpha-Synuclein in Parkinson’s Disease [PDF]

Journal of Movement Disorders, 2011
The purpose of this paper is to provide the rationale for therapeutic silencing of the alpha-synuclein gene (SNCA) in Parkinson’s disease (PD). The paper reviews the public health significance of PD; the causal links between rare SNCA variants and ...
Demetrius M. Maraganore
doaj   +1 more source