Results 41 to 50 of about 15,713 (203)

Genetic Elements at the Alpha-Synuclein Locus

Frontiers in Neuroscience, 2022
Genome-wide association studies have consistently shown that the alpha-synuclein locus is significantly associated with Parkinson’s disease. The mechanism by which this locus modulates the disease pathology and etiology remains largely under-investigated.
Jordan Prahl, Gerhard A. Coetzee
doaj   +1 more source

In vivo silencing of alpha-synuclein using naked siRNA

Molecular Neurodegeneration, 2008
Background Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem.
Charisse Klaus, Toudjarska Ivanka, Kent Caroline, Hinkle Kelly, Ogholikhan Sina, He Zhen, Braithwaite Adam, Lincoln Sarah, Zehr Cynthia, Hope Andrew, Bumcrot David, Melrose Heather, Lewis Jada, Braich Ravi, Pandey Rajendra K, Heckman Michael, Maraganore Demetrius M, Crook Julia, Farrer Matthew J   +18 more
doaj   +1 more source

Prospective of SNCA in nervous system diseases [PDF]

Ibrain, 2017
Synuclein alpha (SNCA), a protein isolated from the Pacific Electric sturgeon, is well‐known for its distribution in the nuclei of neurons and could charge the organ choline. Immunohistochemical staining showed that synuclein were distributed in the synaptic terminal, also expressed in the postsynaptic membrane and synaptic cleft, involving in the ...
Chao Jia, Wei Liu
openaire   +1 more source

Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain

Parkinson's Disease, 2012
Duplications and triplications of the α-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk.
Alexandra Dumitriu, Carlee Moser, Tiffany C. Hadzi, Sally L. Williamson, Christopher D. Pacheco, Audrey E. Hendricks, Jeanne C. Latourelle, Jemma B. Wilk, Anita L. DeStefano, Richard H. Myers   +9 more
doaj   +1 more source

A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism

Frontiers in Neurology, 2018
Chronic alpha-synuclein (SNCA) overexpression is a relatively homogenous and well-defined cause of parkinsonism and dementia. Parkinson's disease (PD), PD with dementia, dementia with Lewy bodies and multiple system atrophy all manifest in SNCA ...
Adam Book, Ilaria Guella, Tara Candido, Alexis Brice, Nobutaka Hattori, Beomseok Jeon, Matthew J. Farrer, SNCA Multiplication Investigators of the GEoPD Consortium   +7 more
doaj   +1 more source

A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease [PDF]

, 2021
There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson’s disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater understanding of the risk factors that
Forland, Marthe Gurine Gunnarsdatter, Macleod, Angus D., Pedersen, Camilla C, Førland, Marthe Gurine, Maple-Grødem, Jodi, Maple-Grodem, Jodi, Alves, Guido, Alves, Guido Werner, Lange, Johannes, Pedersen, Camilla Christina   +9 more
core   +1 more source

Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease [PDF]

Frontiers in Aging Neuroscience, 2019
Background: Genetic factors have a well-known influence on Parkinson's disease (PD) susceptibility; however, no previous studies have investigated the influence of SNCA mutations on the natural history of PD using a prospective follow-up study. The aim of this study was to assess the risk factors of variation of SNCA on the prognosis symptoms of PD ...
Ningdi Luo, Yuanyuan Li, Mengyue Niu, Liche Zhou, Mengsha Yao, Lin Zhu, Guanyu Ye, Wenyan Kang, Wenyan Kang, Jun Liu, Jun Liu   +10 more
openaire   +3 more sources

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies

, 2004
The authors recently have shown that triplication of the alpha-synuclein gene (SNCA) can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients
Singleton, A. A., Hague, S. M., McKeith, I. G., Eerola, J., Perry, R. H., Wilson, K. E., Burn, D. J., Evans, E. W., Ravina, B., Ryu, M., McInerney-Leo, A., Gallardo, M., Hardy, J., Tienari, P., Hanson, M., Johnson, J., Weiser, R., Singleton, A. B., Hernandez, D. G., Gibson, A., Jaros, E., Morris, C. M., Hellstrom, O., Nussbaum, R. L., Gwinn-Hardy, K.   +24 more
core   +1 more source

Спосіб ПЛР-ПДФР аналізу поліморфізму гена альфа-синуклеїну SNCA rs2583988 [PDF]

, 2018
Винахід належить до способу ПЛР-ПДРФ аналізу однонуклеотидного поліморфізму гена альфасинуклеїну SNCA rs2583988, шляхом рестриктного аналізу фрагмента гена SNCA, попередньо ампліфікованого за допомогою полімеразної ланцюгової ...
Таряник, Катерина Анатоліївна, Литвиненко, Наталія Володимирівна   +1 more
core   +1 more source