Results 11 to 20 of about 15,713 (203)

Neuronal SNCA transcription during Lewy body formation

Acta Neuropathologica Communications, 2023
Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson’
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Ivan Martinez‑Valbuena, Jun Li, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs   +8 more
doaj   +4 more sources

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation [PDF]

Molecular Neurodegeneration, 2015
BackgroundWe and others have described the neurodegenerative disorder caused by G51D SNCA mutation which shares characteristics of Parkinson’s disease (PD) and multiple system atrophy (MSA).
Quinn, Niall, Holton, Janice L., Lubbe, Steven, Roberts, HC, Kara, E., Lewis, Patrick A., Hardy, John, Revesz, Tamas, Morris, HR, Lees, Andrew J, Roberts, H.C., Hardy, J, Schapira, Anthony H, Schapira, Anthony, Kiely, Aoife P, Hardy, J., Holton, J.L., Proukakis, Christos, Holton, J L, Asi, Y T, Morris, H.R., Asi, Yasmine T., Lees, A J, Lewis, Patrick, Schapira, A.H., Lees, A.J., Asi, Yasmine T, Lubbe, S., Limousin, P., Ling, H, Schapira, A H, Morris, Huw, Lees, Andrew J., Asi, Yasmine, Roberts, Helen C, Kiely, A P, Ling, H., Lewis, PA, Revesz, T, Kiely, AP, Morris, H R, Lees, AJ, Ling, Helen, Revesz, T., Lees, Andrew, Proukakis, C, Schapira, AH, Houlden, H, Kara, E, Limousin, P, Lewis, Patrick A, Lubbe, S, Kiely, Aoife, Morris, Huw R., Asi, YT, Asi, Y.T., Love, S., Kiely, Aoife P., Quinn, N., Quinn, N, Schapira, Anthony H., Limousin, Patricia, Proukakis, C., Holton, Janice L, Morris, Huw R, Lewis, P.A., Roberts, Helen, Houlden, Henry, Kiely, A.P., Love, Seth, Lewis, P A, Holton, JL, Kara, Eleanna, Roberts, Helen C., Holton, Janice, Love, S   +75 more
core   +11 more sources

Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice. [PDF]

PLoS ONE, 2010
BACKGROUND: Alpha-synuclein (α-Syn) is a small neuronal protein that has been found to be expressed throughout the brain. It has been shown that α-Syn regulates the homeostasis of monoamine neurotransmitters and is involved in various degenerative and ...
Natalia N Kudryavtseva, Natalia P Bondar, Ul'yana A Boyarskikh, Maxim L Filipenko   +3 more
doaj   +3 more sources

SNCA 3′ UTR Genetic Variants in Patients with Parkinson’s Disease [PDF]

Biomolecules, 2021
The SNCA (Synuclein Alpha) gene represents a major risk gene for Parkinson’s disease (PD) and SNCA polymorphisms have been associated with the common sporadic form of PD.
Antonela Blažeković, Borovečki, Fran, Fran Borovečki, Gotovac Jerčić, Kristina, Kristina Gotovac Jerčić, Blažeković, Antonela   +5 more
core   +7 more sources

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex [PDF]

Acta Neuropathologica Communications, 2022
Antisense oligonucleotide (ASO) therapy for neurological disease has been successful in clinical settings and its potential has generated hope for Alzheimer’s disease (AD).
Jennifer L. Brown, Damyan W. Hart, Gabriel E. Boyle, Taylor G. Brown, Michael LaCroix, Andrés M. Baraibar, Ross Pelzel, Minwoo Kim, Mathew A. Sherman, Samuel Boes, Michelle Sung, Tracy Cole, Michael K. Lee, Alfonso Araque, Sylvain E. Lesné   +14 more
doaj   +2 more sources

Peripheral SNCA+ cells as a poor prognostic factor for nivolumab therapy in advanced gastric cancer

Discover Oncology
Background We previously demonstrated that immune cells expressing α-synuclein (SNCA) are dramatically increased in peripheral blood of patients with gastric cancer (GC), but rarely in healthy donors, and that blocking SNCA is significantly effective ...
Chie Kudo-Saito, Hiroshi Imazeki, Kengo Nagashima, Hirokazu Shoji, Kai Tsugaru, Naoki Takahashi, Takeshi Kawakami, Yusuke Amanuma, Takeru Wakatsuki, Naohiro Okano, Yukiya Narita, Yoshiyuki Yamamoto, Rika Kizawa, Kei Muro, Narikazu Boku   +14 more
doaj   +2 more sources

Lack of epistatic interaction of SNCA with APOE in synucleinopathies [PDF]

Brain Communications
Two recent studies suggested that the APOE ε4 haplotype was associated with increased α-synuclein pathology in cell and mouse models. Genetic variants in the SNCA region have strong association with Parkinson’s disease (PD), dementia with Lewy bodies ...
Asayesh, Farnaz, Dauvilliers, Yves, Krohn, Lynne, Montplaisir, Jacques Y, Bernardini, Andrea, Spiegelman, Dan, Rudakou, Uladzislau, Kaivola, Karri, Gagnon, Jean-François, Saini, Prabhjyot, Šonka, Karel, Gan-Or, Ziv, Kemlink, David, Hu, Michele T M, Laurent, Sandra B, Ruskey, Jennifer A, Estiar, Mehrdad A, Janzen, Annette, Mufti, Kheireddin, Yu, Eric, Janes, Francesco, Gigli, Gian Luigi, Desautels, Alex, Valente, Mariarosaria, Arnulf, Isabelle, Oertel, Wolfgang H   +25 more
core   +5 more sources

Interpreting Gene Expression Effects of Disease-Associated Variants: A Lesson from SNCA rs356168 [PDF]

Frontiers in Genetics, 2017
The SNCA intronic single nucleotide polymorphism (SNP), rs356168, has been associated with Parkinson’s disease (PD) in large genome wide association studies (GWAS). Recently, the PD-risk allele, rs356168-G was shown to increase SNCA-mRNA expression using
Omolara-Chinue Glenn, Omolara-Chinue Glenn, Lidia Tagliafierro, Lidia Tagliafierro, Thomas G. Beach, Randy L. Woltjer, Ornit Chiba-Falek, Ornit Chiba-Falek   +7 more
doaj   +2 more sources

Four Copies of SNCA Responsible for Autosomal Dominant Parkinson’s Disease in Two Italian Siblings [PDF]

Parkinson's Disease, 2015
Background. Parkinson’s disease (PD) is mostly characterized by alpha-synuclein (SNCA) aggregation and loss of nigrostriatal dopamine-containing neurons.
Rosangela Ferese, Nicola Modugno, Rosa Campopiano, Marco Santilli, Stefania Zampatti, Emiliano Giardina, Annamaria Nardone, Diana Postorivo, Francesco Fornai, Giuseppe Novelli, Edoardo Romoli, Stefano Ruggieri, Stefano Gambardella   +12 more
doaj   +2 more sources

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models [PDF]

, 2022
Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the ...
Dejung, Mario, Werner, Christian, Rose-John, Stefan, Drobny, Alice, Arnold, Philipp, Prieto Huarcaya, Susy, Balta, Denise, Stojkovska, Iva, Mazzulli, Joseph R, Belur, Nandkishore R, Rizo, Tania, Belur, Nandkishore R., Gallwitz, Lisa, Fulzele, Amitkumar, Marques, André R A, Winner, Beate, Zunke, Friederike, Bub, Simon, Fogh, Jens, Xiang, Wei, Dobert, Jan Philipp, Saftig, Paul, Di Spiezio, Alessandro, Marques, André R. A., Sauer, Markus   +24 more
core   +4 more sources