Results 61 to 70 of about 23,205 (164)

PINK1 phosphorylates ubiquitin predominantly in astrocytes [PDF]

npj Parkinson's Disease, 2019
AbstractLoss-of-function mutations in PINK1 are causally linked to recessively inherited Parkinson’s disease (PD), with marked loss of dopaminergic neurons in the substantia nigra that are required for normal movement. PINK1 is a nuclear-encoded mitochondrial-targeted kinase that phosphorylates a conserved serine at amino acid 65 (pS65) in ubiquitin as
Sandeep K. Barodia, Laura J. McMeekin, Rose B. Creed, Elijah K. Quinones, Rita M. Cowell, Matthew S. Goldberg   +5 more
openaire   +2 more sources

PINK1 and Parkin to control mitochondria remodeling [PDF]

Anatomy & Cell Biology, 2010
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is characterized by movement disorders and a loss of dopaminergic (DA) neurons. PD mainly occurs sporadically, but may also result from genetic mutations in several PD-linked genes.
Koh, Hyongjong, Chung, Jongkyeong
openaire   +2 more sources

PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import [PDF]

The Journal of Biochemistry, 2019
Abstract PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase whose activity is tightly regulated by the mitochondrial health status. In response to mitochondrial damage, activated PINK1 can promote mitophagy, an autophagic elimination of damaged mitochondria, by cooperating with Parkin ubiquitin ligase.
openaire   +2 more sources

The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants.

PLoS Genetics, 2012
Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery.
Sven Vilain, Giovanni Esposito, Dominik Haddad, Onno Schaap, Mariya P Dobreva, Melissa Vos, Stefanie Van Meensel, Vanessa A Morais, Bart De Strooper, Patrik Verstreken   +9 more
doaj   +1 more source

Increased cysteine metabolism in PINK1 models of Parkinson's disease

Disease Models & Mechanisms, 2023
Marco Travaglio, Filippos Michopoulos, Yizhou Yu, Rebeka Popovic, Edmund Foster, Muireann Coen, L. Miguel Martins   +6 more
doaj   +1 more source

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions.

PLoS ONE, 2015
Mutations of the PTEN-induced putative kinase 1 (PINK1) gene are a cause of autosomal recessive forms of Parkinson's disease. Recent studies have revealed that PINK1 is an essential factor for controlling mitochondrial quality, and that it protects cells
Hitoshi Murata, Hitoshi Takamatsu, Sulai Liu, Ken Kataoka, Nam-Ho Huh, Masakiyo Sakaguchi   +5 more
doaj   +1 more source

A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

Cell Discovery
PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy.
Mingzhu Tang, Dade Rong, Xiangzheng Gao, Guang Lu, Haimei Tang, Peng Wang, Ning-Yi Shao, Dajing Xia, Xin-Hua Feng, Wei-Feng He, Weilin Chen, Jia-Hong Lu, Wei Liu, Han-Ming Shen   +13 more
doaj   +1 more source

Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice.

PLoS ONE, 2011
BackgroundPTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice. To reveal additional mechanisms of Pink1-related
Ravi S Akundi, Zhenyu Huang, Joshua Eason, Jignesh D Pandya, Lianteng Zhi, Wayne A Cass, Patrick G Sullivan, Hansruedi Büeler   +7 more
doaj   +1 more source

The Roles of PINK1 and Parkin in Parkinson's Disease

PLoS Biology, 2010
​ResearchResearch into the causes of both sporadic and familial Parkinson's disease have led to the idea that a key risk factor might be mitochondrial dysfunction. The neurons of the substantia nigra, which are specifically lost in Parkinson's disease, seem to be especially vulnerable to the effects of mitochondrial damage.
openaire   +4 more sources

PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction

Clinical and Translational Medicine
Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex condition characterized by metabolic dysfunction and myocardial lipotoxicity.
Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren   +10 more
doaj   +1 more source