Results 1 to 10 of about 39,849 (120)
Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice
npj Parkinson's Disease, 2022 Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression. Mutations of mitochondrial E3 ligase, PARKIN, have been associated with juvenile PD.
Nesibe Peker +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang +14 more
doaj +1 more source
Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder
Translational Psychiatry, 2021 There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose.
Akhil Sharma +3 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Parkin, an E3 ubiquitin ligase, plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy. Accumulating evidence suggests that the acetylation modification of the key mitophagy machinery influences ...
Xin Sun +7 more
doaj +1 more source
Parkin is protective against proteotoxic stress in a transgenic zebrafish model. [PDF]
PLoS ONE, 2010 Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial ...
Mareike E Fett +7 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2023 Brain aging is a complex biological process that is affected by both genetic background and environment. The transcriptomic analysis of aged human and rodent brains has been applied to identify age-associated molecular and cellular processes for which ...
Hyojung Kim +11 more
doaj +1 more source
Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Cell & Bioscience, 2023 Background Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density.
Eun-Young Kim +10 more
doaj +1 more source
Journal of Integrative Neuroscience, 2023 Background: Synucleinopathies, which are major pathological features of Parkinson’s disease (PD), are characterized by misfolded aggregates of α-synuclein in the peripheral and central nervous system.
Denglei Ma +4 more
doaj +1 more source
Journal of Traditional Chinese Medical Sciences, 2020 Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma +9 more
doaj +1 more source
Post-translational modification of Parkin and its research progress in cancer
Cancer Communications, 2019 Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene, which itself belongs to ...
Dan Ding +7 more
doaj +1 more source