Results 31 to 40 of about 40,126 (261)

Resveratrol Treatment in Human Parkin-Mutant Fibroblasts Modulates cAMP and Calcium Homeostasis Regulating the Expression of Mitochondria-Associated Membranes Resident Proteins

Biomolecules, 2021
Parkin plays an important role in ensuring efficient mitochondrial function and calcium homeostasis. Parkin-mutant human fibroblasts, with defective oxidative phosphorylation activity, showed high basal cAMP level likely ascribed to increased activity ...
Anna Signorile, Anna Ferretta, Consiglia Pacelli, Nazzareno Capitanio, Paola Tanzarella, Maria Laura Matrella, Alessio Valletti, Domenico De Rasmo, Tiziana Cocco   +8 more
doaj   +1 more source

Parkin and Parkinson Disease [PDF]

Clinical Chemistry, 2012
Featured Article: Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000;25:302–5.5 Since the 1970s, Japanese neurologists have described patients with autosomal recessive forms of familial Parkinson disease (PD),6 which have been termed ...
Hideki, Shimura, Yoshikuni, Mizuno, Nobutaka, Hattori   +2 more
openaire   +2 more sources

Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

Scientific Reports, 2017
The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to
Kim Han, Shahin Hassanzadeh, Komudi Singh, Sara Menazza, Tiffany T. Nguyen, Mark V. Stevens, An Nguyen, Hong San, Stasia A. Anderson, Yongshun Lin, Jizhong Zou, Elizabeth Murphy, Michael N. Sack   +12 more
doaj   +1 more source

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function [PDF]

Human Molecular Genetics, 2005
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the development of the more common, sporadic form of Parkinson's disease (PD).
Wang, C., Chew, K.C.M., Tay, S.-P., Ho, M.W.L., Lim, K.-L., Lim, T.-M., Tsang, F., Soong, T.-W., Ko, H.S., Thomas, B., Dawson, V.L., Dawson, T.M., Troncoso, J., Pletnikova, O.   +13 more
openaire   +2 more sources

Parkin Promotes Airway Inflammatory Response to Interferon Gamma

Biomedicines, 2023
Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment.
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Taylor Nichols, Hong Wei Chu   +4 more
doaj   +1 more source

Parkin enhances sensitivity of paclitaxel to nasopharyngeal carcinoma by activating BNIP3/NIX-mediated mitochondrial autophagy

Chinese Journal of Physiology, 2023
As a malignant head and neck cancer, nasopharyngeal carcinoma (NPC) has high morbidity. Parkin expression has been reported to be reduced in NPC tissues and its upregulation could enhance paclitaxel-resistant cell cycle arrest.
Haifeng Ni, Renhui Liu, Zhen Zhou, Bo Jiang, Bin Wang   +4 more
doaj   +1 more source

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.

PLoS Biology, 2010
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy.
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle   +7 more
doaj   +1 more source

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Neurobiology of Disease, 2015
Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation, and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD).
Victor S. Van Laar, Nikita Roy, Annie Liu, Swati Rajprohat, Beth Arnold, April A. Dukes, Cory D. Holbein, Sarah B. Berman   +7 more
doaj   +1 more source

The synaptic function of parkin [PDF]

Brain, 2017
Loss of function mutations in the gene PARK2, which encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by degeneration of the dopaminergic neurons localized in the substantia nigra pars compacta.
SASSONE PAGANO, JENNY, Serratto, Giuliamaia, VALTORTA, FLAVIA, Silani, Vincenzo, Passafaro, Maria, Ciammola, Andrea   +5 more
openaire   +5 more sources

Parkin-deficient mice are not more sensitive to 6-hydroxydopamine or methamphetamine neurotoxicity

BMC Neuroscience, 2005
Background Autosomal recessive juvenile parkinsonism (AR-JP) is caused by mutations in the parkin gene which encodes an E3 ubiquitin-protein ligase. Parkin is thought to be critical for protecting dopaminergic neurons from toxic insults by targeting ...
Palmiter Richard D, Curtis Wendy R, Perez Francisco A   +2 more
doaj   +1 more source