Results 31 to 40 of about 59,114 (301)
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
PLoS Biology, 2010 Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy.
Derek P Narendra +7 more
doaj +1 more source
Chinese Journal of Physiology, 2023 As a malignant head and neck cancer, nasopharyngeal carcinoma (NPC) has high morbidity. Parkin expression has been reported to be reduced in NPC tissues and its upregulation could enhance paclitaxel-resistant cell cycle arrest.
Haifeng Ni +4 more
doaj +1 more source
JAMA Neurology, 2013 Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal recessive juvenile-onset and young-onset parkinsonism. The few available detailed neuropathologic reports suggest that homozygous and compound heterozygous parkin mutations are characterized by severe substantia nigra pars compacta neuronal loss.To investigate whether ...
Doherty, K +15 more
openaire +2 more sources
Central Parkin: The evolving role of Parkin in the heart
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2016 Parkin is familiar to many because of its link to Parkinson's disease, and to others because of its well-characterized role as a central factor mediating selective mitophagy of damaged mitochondria for mitochondrial quality control. The genetic connection between Parkin and Parkinson's disease derives from clinical gene-association studies, whereas our
openaire +2 more sources
The synaptic function of parkin [PDF]
Brain, 2017 Loss of function mutations in the gene PARK2, which encodes the protein parkin, cause autosomal recessive juvenile parkinsonism, a neurodegenerative disease characterized by degeneration of the dopaminergic neurons localized in the substantia nigra pars compacta.
SASSONE PAGANO, JENNY +5 more
openaire +5 more sources
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.
PLoS ONE, 2010 Loss-of-function mutations in the PINK1 or parkin genes result in recessive heritable forms of parkinsonism. Genetic studies of Drosophila orthologs of PINK1 and parkin indicate that PINK1, a mitochondrially targeted serine/threonine kinase, acts ...
Angela C Poole +4 more
doaj +1 more source
Phenotypic Discordance in Siblings with Identical Compound Heterozygous PARK2 Mutations
Brain Sciences, 2017 PARK2 mutations are the most common cause of early-onset Parkinson’s disease. No genotype-phenotype correlation exists, and phenotypic variability is quite common.
David Isaacs +3 more
doaj +1 more source
Exploring the consequences of NLRP3 inflammasome pathway overactivation in Parkin-deficient models
, 2022 reservedCompelling evidence have highlighted the central role played by mitochondrial dysfunction and neuroinflammation in the susceptibility and progression of Parkinson’s disease (PD).
SGARBOSSA, LINDA
core
Evidence for Itinerant Ferromagnetic Flat Bands Producing Large Transverse Responses
Advanced Materials, EarlyView.Itinerant ferromagnetic flat bands are demonstrated in GdCo5 with a high Curie temperature of 940K, a stacked honeycomb–kagome lattice, through angle‐resolved photoemission spectroscopy and magneto‐thermoelectric measurements. These topological flat bands generate large Berry curvaturte, producing gigantic anomalous Nernst effect with record‐high ...
Susumu Minami +15 more
wiley +1 more source
Measuring the Hall Effect in Hysteretic Materials
Advanced Materials, EarlyView.The authors highlight common pitfalls in measuring the Hall effect: in hysteretic magnets, improper data processing can create signals that look exotic but are not real. This Perspective explains the origin of these artifacts and presents practical measurement strategies that help researchers identify reliable Hall responses in complex magnetic ...
Jaime M. Moya +6 more
wiley +1 more source