Results 31 to 40 of about 44,057 (302)

Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

Cell Communication and Signaling, 2019
Background Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation.
Dong Hun Lee, Mi Hee Park, Chul Ju Hwang, Youngsoo Kim, Dae Yeon Hwang, Sang Bae Han, Jin Tae Hong   +6 more
doaj   +1 more source

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function [PDF]

Human Molecular Genetics, 2005
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the development of the more common, sporadic form of Parkinson's disease (PD).
Wang, C., Chew, K.C.M., Tay, S.-P., Ho, M.W.L., Lim, K.-L., Lim, T.-M., Tsang, F., Soong, T.-W., Ko, H.S., Thomas, B., Dawson, V.L., Dawson, T.M., Troncoso, J., Pletnikova, O.   +13 more
openaire   +2 more sources

Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice

Frontiers in Aging Neuroscience, 2023
Brain aging is a complex biological process that is affected by both genetic background and environment. The transcriptomic analysis of aged human and rodent brains has been applied to identify age-associated molecular and cellular processes for which ...
Hyojung Kim, Yu-Jin Huh, Yu-Jin Huh, Ji Hun Kim, Minkyung Jo, Joo-Heon Shin, Joo-Heon Shin, Sang Chul Park, Sang Chul Park, Jee-Yin Ahn, Yun-Il Lee, Yunjong Lee   +11 more
doaj   +1 more source

Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

Scientific Reports, 2017
The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to
Kim Han, Shahin Hassanzadeh, Komudi Singh, Sara Menazza, Tiffany T. Nguyen, Mark V. Stevens, An Nguyen, Hong San, Stasia A. Anderson, Yongshun Lin, Jizhong Zou, Elizabeth Murphy, Michael N. Sack   +12 more
doaj   +1 more source

Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2

Journal of Integrative Neuroscience, 2023
Background: Synucleinopathies, which are major pathological features of Parkinson’s disease (PD), are characterized by misfolded aggregates of α-synuclein in the peripheral and central nervous system.
Denglei Ma, Cong Shen, Xu Zhang, Lan Zhang, Lin Li   +4 more
doaj   +1 more source

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PLoS Genetics, 2014
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria ...
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai   +9 more
doaj   +1 more source

Implication of alterations in Parkin gene among North Indian patients with colorectal cancer

The Turkish Journal of Gastroenterology, 2020
Background/Aims: Alterations in Parkin (PRKN) have been described in many cancers; however, the molecular mechanism that contributes to loss of Parkin expression in colorectal cancer (CRC) remains unclear.
Raj Ranjan Tiwari, Khushnuma Wahabi, Ahmad Perwez, Zafar Iqbal Bhat, Syed Shamimul Hasan, Sundeep Singh Saluja, Moshahid Alam Rizvi   +6 more
doaj   +1 more source

Mitophagy in Diabetic Kidney Disease

Frontiers in Cell and Developmental Biology, 2021
Diabetic kidney disease (DKD) is the most common cause of end-stage kidney disease worldwide and is the main microvascular complication of diabetes.
Xiaofeng Zhang, Jing Feng, Xia Li, Dan Wu, Qian Wang, Shuyu Li, Changhua Shi   +6 more
doaj   +1 more source

PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models

Biomedicines, 2023
Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait.
Kyong-hwa Kang, Ji Eun Han, Hyunjin Kim, Sohee Kim, Young Bin Hong, Jeanho Yun, Soo Hyun Nam, Byung-Ok Choi, Hyongjong Koh   +8 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source