Results 51 to 60 of about 59,114 (301)

Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2

Journal of Translational Medicine
Background Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch ondrial Stomatin-like protein 2 (SLP-2), which functions in the ...
Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks, Irene Pichler   +9 more
doaj   +1 more source

Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

eLife
Loss-of-function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by the PINK1 kinase. Herein, we demonstrate a
Dipti Ranjan Lenka, Shakti Virendra Dahe, Odetta Antico, Pritiranjan Sahoo, Alan R Prescott, Miratul MK Muqit, Atul Kumar   +6 more
doaj   +1 more source

3D Engineered Dual‐Redox Zinc‐Iodine Microbatteries for Intrinsically Safe on‐Chip Energy Storage

Advanced Science, EarlyView.
Dual‐redox Zn//I2 microbatteries enable high‐performance on‐chip energy storage by combining Zn2+ plating/stripping with reversible I−/I3− chemistry. Integrated with PANI micro‐cathode and 3D porous Au collectors, the system delivers enhanced capacity, energy, and power, advancing safe, CMOS‐compatible microsystems for next‐generation electronics ...
Nibagani Naresh, Sanat Nalini Paltasingh, Yijia Zhu, Xiaopeng Liu, Yujia Fan, Monojit Mondal, Su Jin Heo, Shuhui Li, Mingqing Wang, Shaoliang Guan, Yanzhuo Li, Georgios Nikiforidis, Shahab Akhavan, Ivan P. Parkin, Saroj Kumar Nayak, Michael De Volder, Buddha Deka Boruah   +16 more
wiley   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Cloning of Rat Parkin cDNA and Distribution of Parkin in Rat Brain [PDF]

Journal of Neurochemistry, 2000
Abstract: The rat parkin cDNA sequence was characterized after screening a rat hypothalamus cDNA library with a 32P‐labeled probe containing the entire open reading frame of the human parkin cDNA. This sequence encompasses 1,576 bp and contains a single open reading frame that encodes a 465‐amino acid protein.
W J, Gu, N, Abbas, M Z, Lagunes, A, Parent, L, Pradier, G A, Bohme, Y, Agid, E C, Hirsch, R, Raisman-Vozari, A, Brice   +9 more
openaire   +2 more sources

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Neurobiology of Disease, 2015
Disruption of the dynamic properties of mitochondria (fission, fusion, transport, degradation, and biogenesis) has been implicated in the pathogenesis of neurodegenerative disorders, including Parkinson's disease (PD).
Victor S. Van Laar, Nikita Roy, Annie Liu, Swati Rajprohat, Beth Arnold, April A. Dukes, Cory D. Holbein, Sarah B. Berman   +7 more
doaj   +1 more source

A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit

Cell Reports, 2023
Summary: Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on healthy mitochondria are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback loop
Christopher S. Waters, Sigurd B. Angenent, Steven J. Altschuler, Lani F. Wu   +3 more
doaj   +1 more source

Herba Lysimachiae Polysaccharide‐Modified Selenium Nanoparticles Alleviate Oxidative Injury in Kidney Stones via TOMM22‐Regulated Mitophagy Activation

Advanced Science, EarlyView.
HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang, Guoruiyu Lyu, Wenlong Wan, Dongfeng Yuan, Jiabo Li, Yongqi Wang, Baokang Wang, Zhilong Ma, Yuanyuan Yang, Yang Xun, Xiao Yu   +10 more
wiley   +1 more source

Implication of alterations in Parkin gene among North Indian patients with colorectal cancer

The Turkish Journal of Gastroenterology, 2020
Background/Aims: Alterations in Parkin (PRKN) have been described in many cancers; however, the molecular mechanism that contributes to loss of Parkin expression in colorectal cancer (CRC) remains unclear.
Raj Ranjan Tiwari, Khushnuma Wahabi, Ahmad Perwez, Zafar Iqbal Bhat, Syed Shamimul Hasan, Sundeep Singh Saluja, Moshahid Alam Rizvi   +6 more
doaj   +1 more source

Cannabidiol activates PINK1-Parkin-dependent mitophagy and mitochondrial-derived vesicles

European Journal of Cell Biology, 2022
The PINK1/Parkin pathway plays an important role in maintaining a healthy pool of mitochondria. Activation of this pathway can lead to apoptosis, mitophagy, or mitochondrial-derived vesicle formation, depending on the nature of mitochondrial damage.
Adrian Ramirez, William Old, David L. Selwood, Xuedong Liu   +3 more
doaj   +1 more source