Results 61 to 70 of about 44,057 (302)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2

Journal of Translational Medicine
Background Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch ondrial Stomatin-like protein 2 (SLP-2), which functions in the ...
Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks, Irene Pichler   +9 more
doaj   +1 more source

How phosphoubiquitin activates Parkin [PDF]

Cell Research, 2015
A recent report, solving the structure of a Parkin-phosphoubiquitin complex, greatly advances the understanding of the Parkin activation mechanism.
Xinde, Zheng, Tony, Hunter
openaire   +2 more sources

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

3D Engineered Dual‐Redox Zinc‐Iodine Microbatteries for Intrinsically Safe on‐Chip Energy Storage

Advanced Science, EarlyView.
Dual‐redox Zn//I2 microbatteries enable high‐performance on‐chip energy storage by combining Zn2+ plating/stripping with reversible I−/I3− chemistry. Integrated with PANI micro‐cathode and 3D porous Au collectors, the system delivers enhanced capacity, energy, and power, advancing safe, CMOS‐compatible microsystems for next‐generation electronics ...
Nibagani Naresh, Sanat Nalini Paltasingh, Yijia Zhu, Xiaopeng Liu, Yujia Fan, Monojit Mondal, Su Jin Heo, Shuhui Li, Mingqing Wang, Shaoliang Guan, Yanzhuo Li, Georgios Nikiforidis, Shahab Akhavan, Ivan P. Parkin, Saroj Kumar Nayak, Michael De Volder, Buddha Deka Boruah   +16 more
wiley   +1 more source

Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson’s disease model

Scientific Reports, 2017
Dysfunctional parkin due to mutations or post-translational modifications contributes to dopaminergic neurodegeneration in Parkinson’s disease (PD). Overexpression of parkin provides protection against cellular stresses and prevents dopamine cell loss in
Sangwoo Ham, Yun-Il Lee, Minkyung Jo, Hyojung Kim, Hojin Kang, Areum Jo, Gum Hwa Lee, Yun Jeong Mo, Sang Chul Park, Yun Song Lee, Joo-Ho Shin, Yunjong Lee   +11 more
doaj   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Phenotypic Discordance in Siblings with Identical Compound Heterozygous PARK2 Mutations

Brain Sciences, 2017
PARK2 mutations are the most common cause of early-onset Parkinson’s disease. No genotype-phenotype correlation exists, and phenotypic variability is quite common.
David Isaacs, Daniel Claassen, Aaron B. Bowman, Peter Hedera   +3 more
doaj   +1 more source

The normal parkin sequence [PDF]

Movement Disorders, 2011
The recruitment of parkin to mitochondria in response to mitochondrial membrane depolarization1 is an important aspect of parkin biology that has attracted extensive research2. We found that parkin with the sequence ({"type":"entrez-nucleotide","attrs":{"text":"AB009973.1","term_id":"3063387","term_text":"AB009973.1"}}AB009973.1) reported in the ...
Yong, Ren, Xiaojun, Liu, Suzanne, Lesage, Miao, Cai, Jiali, Pu, Baorong, Zhang, Alexis, Brice, Jian, Feng   +7 more
openaire   +2 more sources

Topological Materials and Related Applications

Advanced Electronic Materials, EarlyView.
This review covers topological materials—including topological insulators, quantum valley Hall and quantum spin Hall insulators, and topological Weyl and Dirac semimetals—as well as their most recent advancements in fields such as spintronics, electronics, photonics, thermoelectrics, and catalysis.
Carlo Grazianetti, Roberto Mantovan, Emanuele Longo, Harold J. W. Zandvliet, Pantelis Bampoulis, Yu Pan, Fan Li, Xia Wang, Payton Downey, Alessandro Molle   +9 more
wiley   +1 more source