Results 61 to 70 of about 40,126 (261)

Ubiquitin, proteasome and parkin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004
The ubiquitin-proteasome system (UPS) is important for intracellular proteolysis, and is responsible for a diverse array of biologically important cellular processes, such as cell-cycle progression, signaling cascades and developmental programs. This system is also involved in the protein quality control, which maintains the health of the cell.
Tanaka, Keiji, Suzuki, Toshiaki, Hattori, Nobutaka, Mizuno, Yoshikuni   +3 more
openaire   +2 more sources

Cloning of Rat Parkin cDNA and Distribution of Parkin in Rat Brain [PDF]

Journal of Neurochemistry, 2000
Abstract: The rat parkin cDNA sequence was characterized after screening a rat hypothalamus cDNA library with a 32P‐labeled probe containing the entire open reading frame of the human parkin cDNA. This sequence encompasses 1,576 bp and contains a single open reading frame that encodes a 465‐amino acid protein.
W J, Gu, N, Abbas, M Z, Lagunes, A, Parent, L, Pradier, G A, Bohme, Y, Agid, E C, Hirsch, R, Raisman-Vozari, A, Brice   +9 more
openaire   +2 more sources

Study on the Reaction Mechanism of RuOx and Its Enhanced Hydrogen Evolution Reaction Activity

Advanced Science, EarlyView.
In situ Raman spectroscopy and DFT calculations reveal that, prior to the onset of HER, the surface of RuOx undergoes reversible reduction and structural reconstruction. The resulting Ru(II)O/Ru(IV)O2 configuration is identified as the true catalytically active species.
Liquan Zhang, Haobo Dong, Jianrui Feng, Longxiang Liu, Fei Guo, Liqun Kang, Guoliang Chai, Mohamed A. Ghanem, Xinde Chen, Ivan P. Parkin   +9 more
wiley   +1 more source

The Interactive Effect of Interval Training Intensity and Curcumin Supplementation on Mitochondrial Bnip3 and Parkin Gene Expression in the Heart Tissue of Male Rats\' Model of Heart Infarction

Journal of Ardabil University of Medical Sciences, 2022
Background & objectives: The increase of Bnip3 and Parkin plays an important role in maintaining mitochondrial function and inhibiting ROS. A correlation was observed between the mitochondrial respiratory capacity and the subjects' mRNA levels of Bnip3 ...
Mohammad Rasoul Mirzaei, Shahram Gholamrezaei, Ramin Shabani   +2 more
doaj  

Parkin Regulation and Neurodegenerative Disorders [PDF]

Frontiers in Aging Neuroscience, 2016
Parkin is a unique, multifunctional ubiquitin ligase whose various roles in the cell, particularly in neurons, are widely thought to be protective. The pivotal role that Parkin plays in maintaining neuronal survival is underscored by our current recognition that Parkin dysfunction represents not only a predominant cause of familial parkinsonism but ...
Chengwu eZhang, Liting eHang, Tso-Pang eYao, Kah-Leong eLim, Kah-Leong eLim   +4 more
openaire   +3 more sources

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Recent Advances in Carbon Cathode Materials toward High‐Performing Zinc‐Ion Hybrid Supercapacitors

Advanced Science, EarlyView.
Aqueous zinc‐ion hybrid supercapacitors (ZHSCs) have emerged as promising next‐generation electrochemical energy‐storage devices. Porous carbon materials have been extensively studied as cathodes, with advances in tailoring pore structures and material properties to enhance performance.
Take Hirooka, Zhaolin Liu, Ivan P. Parkin, Guanjie He   +3 more
wiley   +1 more source

Parkin mitochondria in the autophagosome [PDF]

The Journal of Cell Biology, 2008
Narendra et al. (see p. 795 of this issue) have made an exciting new discovery that links the fields of mitochondrial quality control and the genetics of Parkinson's disease (PD). Through an elegant series of high-resolution imaging experiments, they are the first to provide evidence that the PARK2 gene product Parkin is selectively recruited to ...
openaire   +2 more sources

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Optimized Antimony‐Doped Tin Oxide Thin Films With Enhanced Electrical Properties for Low‐Emissivity Architectural Coatings

Advanced Science, EarlyView.
Antimony‐doped tin oxide (ATO) thin films were deposited by aerosol‐assisted chemical vapor deposition (AACVD) and systematically investigated to establish correlations between Sb doping level, structural properties and optoelectronic performance. Optimized films exhibited low sheet resistance, high carrier concentrations, and high visible transparency
Iqra Ramzan, Ivan P. Parkin, Claire J. Carmalt   +2 more
wiley   +1 more source