Results 81 to 90 of about 59,114 (301)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson’s Disease Patients

Parkinson's Disease, 2016
Mutations in the parkin gene are the most common cause of early-onset Parkinson’s disease (PD). Parkin, an E3 ubiquitin ligase, is involved in respiratory chain function, mitophagy, and mitochondrial dynamics.
William Haylett, Chrisna Swart, Francois van der Westhuizen, Hayley van Dyk, Lize van der Merwe, Celia van der Merwe, Ben Loos, Jonathan Carr, Craig Kinnear, Soraya Bardien   +9 more
doaj   +1 more source

Clinical, 18f-Dopa Pet, and Genetic Analysis of an Ethnic Chinese Kindred with Early-Onset Parkinsonism and Parkin Gene Mutations

, 2009
We report on clinical F-18-labeled 6-fluorodopa (F-18-dopa) positron emission tomography (PET) and molecular genetic analyses of an ethnic Chinese family in which three siblings presented with early-onset Parkinson's disease.
WU, RUEY-MEEI;HWU, WUH-LIANG, 吳瑞美;胡務亮   +1 more
core  

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, EarlyView.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

Arrestin‐3 binds parkin and enhances parkin‐dependent mitophagy

Journal of Neurochemistry
Abstract Arrestins were discovered for their role in homologous desensitization of G‐protein‐coupled receptors (GPCRs). Later non‐visual arrestins were shown to regulate several signaling pathways. Some of these pathways require arrestin binding to GPCRs, the regulation of others is receptor independent.
Chen Zheng, Kevin K. Nguyen, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Eugenia V. Gurevich   +4 more
openaire   +3 more sources

ESLO1: interview de personnalité 430

, 2015
Extrait du corpus d'Orléans, réalisé dans le cadre de l'Enquête SocioLinguistique à Orléans à la fin des années 1960.Syndicats/politiquedescription et historique Charbonnages de France ; répartition des houillères ; conseil d'administration ; la CECA ...
Blanc, Michel, Biggs, Patricia, Laboratoire Ligérien de Linguistique, Parkin, Dorothy   +3 more
core   +1 more source

Development of a sustainable water treatment process using biochar as substrate for filtration and coliform removal

The Canadian Journal of Chemical Engineering, EarlyView.
Preparation, modification, and characterization of biochar from woodchips and its application in stream water filtration, evaluated through physicochemical and microbiological analyses. Abstract Global microbial water contamination affects 1.8 billion people, necessitating efficient and sustainable treatment methods.
Tariq Khalil, Muhammad Ishtiaq Ali, Rameesha Abid, Anab Mujtaba, Rabia Asghar, Asif Jamal, Yusuf Tutar, Ahsan Habib, Fakhraddin Yusubov   +8 more
wiley   +1 more source

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

Cell Reports, 2014
Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defective mitochondria via mitophagy. Because Parkin mutations
Richard G. Carroll, Emilie Hollville, Seamus J. Martin   +2 more
doaj   +1 more source

Parkin Mutations and Early-Onset Parkinsonism in a Taiwanese Cohort

, 2008
Background: Loss of function of the parkin gene (PRKN) is the predominant genetic cause of juvenile and earlyonset parkinsonism in Japan, Europe, and the United States. Objectives: To evaluate the frequency of PRKN mutations in Taiwanese (ethnic Chinese)
吳瑞美;林靜嫻;胡務亮, Wu, Ruey-Meei; Bounds, Rebecca; Lincoln, Sarah; Hulihan, Mary; Lin, Chin-Hsien; Hwu, Wuh-Liang; Chen, Judy; Gwinn-Hardy, Katrina; Farrer, Matt   +1 more
core  

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source