Results 81 to 90 of about 44,057 (302)

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

The costs of extra‐pair behaviours in birds

Biological Reviews, EarlyView.
ABSTRACT Extra‐pair behaviours – reproductive behaviours, including those related to copulation and paternity of offspring, amongst animals outside of a social pair bond – have long intrigued behavioural ecologists, particularly from the female animal's perspective.
Jørgen S. Søraker, Jamie Dunning
wiley   +1 more source

Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin

iScience
Summary: The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate UB transfer to substrate proteins, and mutations affecting Parkin catalysis promote cancer and are associated with Parkinson’s disease. An essential role of
Shuai Fang, Li Zhou, Geng Chen, Jing Zhang, Xiaoyu Wang, In Ho Jeong, Savannah E. Jacobs, Bradley R. Kossmann, Wei Wei, Shu Liu, Geon H. Jeong, Yayun Xie, Duc Duong, Nicholas T. Seyfried, Ivaylo Ivanov, Angela M. Mabb, Hiroaki Kiyokawa, Bo Zhao, Jun Yin   +18 more
doaj   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

The Proteomic Landscape of Parkin-Deficient and Parkin-Overexpressing Rat Nucleus Accumbens: An Insight into the Role of Parkin in Methamphetamine Use Disorder

Biomolecules
In recent years, methamphetamine (METH) misuse in the US has been rapidly increasing, and there is no FDA-approved pharmacotherapy for METH use disorder (MUD). We previously determined that ubiquitin-protein ligase parkin is involved in the regulation of
Akhil Sharma, Tarek Atasi, Florine Collin, Weiwei Wang, TuKiet T. Lam, Rolando Garcia-Milian, Tasnim Arroum, Lucynda Pham, Maik Hüttemann, Anna Moszczynska   +9 more
doaj   +1 more source

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

Cell Reports, 2014
Mitochondrial depolarization promotes Parkin- and PTEN-induced kinase 1 (PINK1)-dependent polyubiquitination of multiple proteins on mitochondrial outer membranes, resulting in the removal of defective mitochondria via mitophagy. Because Parkin mutations
Richard G. Carroll, Emilie Hollville, Seamus J. Martin   +2 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of Cardiac Interoceptive Accuracy in Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Interoceptive impairments have been suggested as an etiological factor in anorexia nervosa (AN) but have not been consistently confirmed across interoceptive dimensions and bodily systems. This systematic review and meta‐analysis provides a focused investigation of cardiac interoceptive accuracy (IAcc) in AN.
Claire Gend, Laure Remy, Annika P. C. Lutz   +2 more
wiley   +1 more source

PARKIN is not required to sustain OXPHOS function in adult mammalian tissues

npj Parkinson's Disease
Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pathways of ...
Roberta Filograna, Jule Gerlach, Hae-Na Choi, Giovanni Rigoni, Michela Barbaro, Mikael Oscarson, Seungmin Lee, Katarina Tiklova, Markus Ringnér, Camilla Koolmeister, Rolf Wibom, Sara Riggare, Inger Nennesmo, Thomas Perlmann, Anna Wredenberg, Anna Wedell, Elisa Motori, Per Svenningsson, Nils-Göran Larsson   +18 more
doaj   +1 more source

Nature‐Based Solutions for Climate Adaptation: Review of Barriers to Adoption and Guidelines for Policymakers

Environmental Policy and Governance, EarlyView.
ABSTRACT Nature‐based solutions (NBS) for climate adaptation encompass a range of approaches that work with nature to increase resilience to climate change while providing ecological, economic and social co‐benefits. These solutions have frequently been put forward for application in urban contexts, such as the creation of urban forests, but can ...
Anita Vollmer, Stefano Ceolotto, Niall Farrell   +2 more
wiley   +1 more source

Ubiquitin, proteasome and parkin

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004
The ubiquitin-proteasome system (UPS) is important for intracellular proteolysis, and is responsible for a diverse array of biologically important cellular processes, such as cell-cycle progression, signaling cascades and developmental programs. This system is also involved in the protein quality control, which maintains the health of the cell.
Tanaka, Keiji, Suzuki, Toshiaki, Hattori, Nobutaka, Mizuno, Yoshikuni   +3 more
openaire   +2 more sources