Results 91 to 100 of about 40,126 (261)

Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson’s disease model

Scientific Reports, 2017
Dysfunctional parkin due to mutations or post-translational modifications contributes to dopaminergic neurodegeneration in Parkinson’s disease (PD). Overexpression of parkin provides protection against cellular stresses and prevents dopamine cell loss in
Sangwoo Ham, Yun-Il Lee, Minkyung Jo, Hyojung Kim, Hojin Kang, Areum Jo, Gum Hwa Lee, Yun Jeong Mo, Sang Chul Park, Yun Song Lee, Joo-Ho Shin, Yunjong Lee   +11 more
doaj   +1 more source

The costs of extra‐pair behaviours in birds

Biological Reviews, EarlyView.
ABSTRACT Extra‐pair behaviours – reproductive behaviours, including those related to copulation and paternity of offspring, amongst animals outside of a social pair bond – have long intrigued behavioural ecologists, particularly from the female animal's perspective.
Jørgen S. Søraker, Jamie Dunning
wiley   +1 more source

High‐throughput development and scale‐up of recombinant adeno‐associated virus 5 anion‐exchange chromatography for high‐purity capsid separation

Biotechnology Progress, EarlyView.
High‐throughput anion‐exchange chromatography process development enables scalable purification of high‐purity recombinant adeno‐associated virus capsids. Abstract Recombinant adeno‐associated virus (rAAV) production commonly yields a high proportion of empty and partially filled capsids, necessitating downstream purification to enrich full capsids ...
Kevin Vera, Ivan Gajic, Praveen Kusumanchi, Angela Andaluz, Gabrielle Dela Pena, Clifford A. Froelich, Elizabeth Higgins, Jennifer Johnston, Seyed Pouria Motevalian   +8 more
wiley   +1 more source

Bone morphogenetic protein 4-associated mitochondrial dysfunction in diabetic nephropathy involves Parkin downregulation

Frontiers in Clinical Diabetes and Healthcare
BackgroundDiabetic nephropathy (DN) is characterized by mesangial expansion and mitochondrial dysfunction. Although bone morphogenetic protein 4 (BMP4) is a pro-fibrotic factor in DN, its role in mesangial mitochondrial homeostasis remains unclear.
Masanori Tamaki, Tatsuya Tominaga, Kazuhiro Hasegawa, Takahiro Kida, Shinji Miyakami, Ikuko Shimizu, Sumiyo Yamaguchi, Masanori Minato, Kojiro Nagai, Kojiro Nagai, Shu Wakino   +10 more
doaj   +1 more source

Dual Regulatory Functions of Classical Zinc Finger Clusters from Myeloid Zinc Finger‐1

Chemistry – A European Journal, EarlyView.
The classical zinc finger (ZF) protein MZF1 uses two ZF clusters to achieve metal‐dependent and gene‐specific promoter recognition. The differential redox stability and modular utilization of the two ZF clusters enable MZF1 to regulate cerebrovascular, neuronal, and cancer‐related transcriptional programs.
Yunha Hwang, Yerim Park, Nohwan Park, Heeju Noh, Hyun Goo Kang, Seung Jae Lee   +5 more
wiley   +1 more source

Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein.

PLoS ONE, 2012
Parkinson's disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD.
Stav Kemeny, Dikla Dery, Yelena Loboda, Marshall Rovner, Tali Lev, Dotan Zuri, John P M Finberg, Sarit Larisch   +7 more
doaj   +1 more source

Development of a sustainable water treatment process using biochar as substrate for filtration and coliform removal

The Canadian Journal of Chemical Engineering, EarlyView.
Preparation, modification, and characterization of biochar from woodchips and its application in stream water filtration, evaluated through physicochemical and microbiological analyses. Abstract Global microbial water contamination affects 1.8 billion people, necessitating efficient and sustainable treatment methods.
Tariq Khalil, Muhammad Ishtiaq Ali, Rameesha Abid, Anab Mujtaba, Rabia Asghar, Asif Jamal, Yusuf Tutar, Ahsan Habib, Fakhraddin Yusubov   +8 more
wiley   +1 more source

Tuning Cation Disorder in LiNi0.5Mn1.5O4 via Room Temperature Continuous‐Flow Co‐Precipitation and Controlled Heat Treatment

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
LiNi0.5Mn1.5O4 (LNMO) precursors were produced at room temperature by Ambient Continuous Turbulent In‐line Mixing (ACTIM) at rates of up to 0.42 kg h−1. The final heat treatment step at 650, 700, or 750 °C, altered cation disorder and the electrochemical behavior of the LNMO cathodes, while the effect of adding MWCNTs to the electrodes, was also ...
Bangxun Yin, Jack J. Quayle, Jiacheng Wang, David Wilde, Ivan P. Parkin, Jawwad A. Darr   +5 more
wiley   +1 more source

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Nature Communications, 2017
Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows ...
Matthew Y. Tang, Marta Vranas, Andrea I. Krahn, Shayal Pundlik, Jean- François Trempe, Edward A. Fon   +5 more
doaj   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source