Results 91 to 100 of about 44,057 (302)

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Altered Mitochondrial Respiration and Other Features of Mitochondrial Function in Parkin-Mutant Fibroblasts from Parkinson’s Disease Patients

Parkinson's Disease, 2016
Mutations in the parkin gene are the most common cause of early-onset Parkinson’s disease (PD). Parkin, an E3 ubiquitin ligase, is involved in respiratory chain function, mitophagy, and mitochondrial dynamics.
William Haylett, Chrisna Swart, Francois van der Westhuizen, Hayley van Dyk, Lize van der Merwe, Celia van der Merwe, Ben Loos, Jonathan Carr, Craig Kinnear, Soraya Bardien   +9 more
doaj   +1 more source

Parkin [PDF]

Neuron, 2003
Feany, Mel B, Pallanck, Leo J
openaire   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

DJ-1 and Parkin Modulate Dopamine-dependent Behavior and Inhibit MPTP-induced Nigral Dopamine Neuron Loss in Mice [PDF]

, 2007
Jean‐Charles Paterna, Andreas Leng, Elisabeth Weber, Joram Feldon, Hansruedi Büeler   +4 more
openalex   +1 more source

Climate change effects on biomass and greenhouse gas emissions are ameliorated by nontoxic endophytes in southeastern USA transition zone tall fescue pastures

Grassland Research, EarlyView.
Tall fescue produces more biomass and less carbon dioxide from the soil when it contains its beneficial fungal endophyte. Increased temperatures projected with climate change reduce fescue biomass, while altered rainfall frequency does not. Altering rainfall frequency and increasing temperatures can reduce carbon dioxide emissions from soil.
Rebecca K. McGrail, Jonathan D. Moore, A. Elizabeth Carlisle, Jim A. Nelson, Rebecca L. McCulley   +4 more
wiley   +1 more source

Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein.

PLoS ONE, 2012
Parkinson's disease (PD) is associated with excessive cell death causing selective loss of dopaminergic neurons. Dysfunction of the Ubiquitin Proteasome System (UPS) is associated with the pathophysiology of PD.
Stav Kemeny, Dikla Dery, Yelena Loboda, Marshall Rovner, Tali Lev, Dotan Zuri, John P M Finberg, Sarit Larisch   +7 more
doaj   +1 more source

PARKIN overexpression in hyperoxia-induced lung injury [PDF]

, 2019
Alexander Czachor, Helena Hernández‐Cuervo, Ramani Soundararajan, Jutaro Fukumoto, Richard F. Lockey, Narasaiah Kolliputi   +5 more
openalex   +1 more source

Patient‐ and caregiver‐reported barriers to radiotherapy for cancer in sub‐Saharan Africa—A survey of population‐based registries

International Journal of Cancer, EarlyView.
What's New? Low‐ and middle‐income countries have over 70% of the global cancer burden but 10% of the world's radiotherapy capacities. This population‐based multi‐country study explores the barriers to access experienced by cancer patients in sub‐Saharan Africa.
Eric Sven Kroeber, Tamara König, Ole Stöter, Biying Liu, Phoebe Mary Amulen, Margaret Borok, Gladys Chesumbai, Eric Chokunonga, Ima‐Obong Ekanem, Mahine Ivanga, Bakarou Kamaté, William Muller, Abidemi Omonisi, Jean‐Félix Peko, Mathewos Assefa, Furaha Serventi, Markus Wallwiener, Mazvita Muchengeti, Pablo Sandro Carvalho Santos, Donald Maxwell Parkin, Eva Johanna Kantelhardt, Nikolaus Christian Simon Mezger   +21 more
wiley   +1 more source

Tyrosine kinase inhibition increases functional parkin‐Beclin‐1 interaction and enhances amyloid clearance and cognitive performance

EMBO Molecular Medicine, 2013
Tyrosine kinase inhibitors (TKIs) are effective therapies for leukaemia. Alzheimer is a neurodegenerative disease characterized by accumulation of β‐amyloid (plaques) and hyper‐phosphorylated Tau (tangles).
Irina Lonskaya, Michaeline L. Hebron, Nicole M. Desforges, Alexander Franjie, Charbel E.‐H. Moussa   +4 more
doaj   +1 more source