Results 21 to 30 of about 59,114 (301)

The normal parkin sequence [PDF]

Movement Disorders, 2011
The recruitment of parkin to mitochondria in response to mitochondrial membrane depolarization1 is an important aspect of parkin biology that has attracted extensive research2. We found that parkin with the sequence ({"type":"entrez-nucleotide","attrs":{"text":"AB009973.1","term_id":"3063387","term_text":"AB009973.1"}}AB009973.1) reported in the ...
Yong, Ren, Xiaojun, Liu, Suzanne, Lesage, Miao, Cai, Jiali, Pu, Baorong, Zhang, Alexis, Brice, Jian, Feng   +7 more
openaire   +2 more sources

Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

Scientific Reports, 2017
The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to
Kim Han, Shahin Hassanzadeh, Komudi Singh, Sara Menazza, Tiffany T. Nguyen, Mark V. Stevens, An Nguyen, Hong San, Stasia A. Anderson, Yongshun Lin, Jizhong Zou, Elizabeth Murphy, Michael N. Sack   +12 more
doaj   +1 more source

Parkin and Parkinson Disease [PDF]

Clinical Chemistry, 2012
Featured Article: Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, et al. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000;25:302–5.5 Since the 1970s, Japanese neurologists have described patients with autosomal recessive forms of familial Parkinson disease (PD),6 which have been termed ...
Hideki, Shimura, Yoshikuni, Mizuno, Nobutaka, Hattori   +2 more
openaire   +2 more sources

Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PLoS Genetics, 2014
The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria ...
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai   +9 more
doaj   +1 more source

Rotenone-Induced Neurodegeneration Is Enabled by a p38-Parkin-ROS Signaling Feedback Loop

, 2021
Rotenone, a component of pesticides, is widely used in agriculture and potentially causes Parkinson’s disease (PD). However, the regulatory mechanisms of rotenone-induced PD are unclear.
Mingque Li (11705062), He Zhang, Xueqiong Zhou (11705065), Jialong Chen (1937167), Ailun Xie (11705068), Linhua Liu, He Zhang (130319), Mingque Li, Ailun Xie, Linhua Liu (8925602), Ziwei Cai (11705071), Chunlai Fu (11705074), Yongming Peng (11705077), Chunlai Fu, Ziwei Cai, Yongming Peng, Xueqiong Zhou, Jialong Chen   +17 more
core   +1 more source

Image1_Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy.tif

, 2022
Doxorubicin (DOX) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe risk of cardiotoxicity.
Jing Cao (287196), Wei Wang (17594), Weili Li (151151), Tianhua Liu (631227), Xiaoping Wang (110673), Yanyan Jiang (253354), Yong Wang (12837), Qian Zhang (49333), Qianbin Sun (11750054), Chun Li (57810)   +9 more
core   +1 more source

Parkin Promotes Airway Inflammatory Response to Interferon Gamma

Biomedicines, 2023
Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment.
Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Taylor Nichols, Hong Wei Chu   +4 more
doaj   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function [PDF]

Human Molecular Genetics, 2005
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the development of the more common, sporadic form of Parkinson's disease (PD).
Wang, C., Chew, K.C.M., Tay, S.-P., Ho, M.W.L., Lim, K.-L., Lim, T.-M., Tsang, F., Soong, T.-W., Ko, H.S., Thomas, B., Dawson, V.L., Dawson, T.M., Troncoso, J., Pletnikova, O.   +13 more
openaire   +2 more sources

Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells

Current Issues in Molecular Biology, 2022
Parkin is a well-established synergistic mediator of mitophagy in dysfunctional mitochondria. Mitochondria are the main target of arsenic trioxide (ATO) cytotoxicity, and the effect of mitophagy on ATO action remains unclear.
Zhewen Zhang, Juan Yi, Bei Xie, Jing Chen, Xueyan Zhang, Li Wang, Jingyu Wang, Jinxia Hou, Hulai Wei   +8 more
doaj   +1 more source