Results 21 to 30 of about 40,126 (261)
Post-translational modification of Parkin and its research progress in cancer
Cancer Communications, 2019 Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene, which itself belongs to ...
Dan Ding +7 more
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Frontiers in Aging Neuroscience, 2023 Brain aging is a complex biological process that is affected by both genetic background and environment. The transcriptomic analysis of aged human and rodent brains has been applied to identify age-associated molecular and cellular processes for which ...
Hyojung Kim +11 more
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Journal of Integrative Neuroscience, 2023 Background: Synucleinopathies, which are major pathological features of Parkinson’s disease (PD), are characterized by misfolded aggregates of α-synuclein in the peripheral and central nervous system.
Denglei Ma +4 more
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Parkinson's Disease, 2017 Conventional medical treatments of Parkinson’s disease (PD) are effective on motor disturbances but may have little impact on nonmotor symptoms, especially psychiatric ones.
Giovanni Mirabella +13 more
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Cell Communication and Signaling, 2019 Background Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation.
Dong Hun Lee +6 more
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Mitophagy in Diabetic Kidney Disease
Frontiers in Cell and Developmental Biology, 2021 Diabetic kidney disease (DKD) is the most common cause of end-stage kidney disease worldwide and is the main microvascular complication of diabetes.
Xiaofeng Zhang +6 more
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Biomedicines, 2023 Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait.
Kyong-hwa Kang +8 more
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The normal parkin sequence [PDF]
Movement Disorders, 2011 The recruitment of parkin to mitochondria in response to mitochondrial membrane depolarization1 is an important aspect of parkin biology that has attracted extensive research2. We found that parkin with the sequence ({"type":"entrez-nucleotide","attrs":{"text":"AB009973.1","term_id":"3063387","term_text":"AB009973.1"}}AB009973.1) reported in the ...
Yong, Ren +7 more
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Cells, 2021 Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective elimination of dysfunctional mitochondria. To this date, parkin depletion has been associated with recessive early onset Parkinson’s disease (PD) caused by loss-of ...
Katarzyna Gaweda-Walerych +3 more
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Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
PLoS Genetics, 2014 The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria ...
Kahori Shiba-Fukushima +9 more
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