Results 21 to 30 of about 44,057 (302)
Frontiers in Cell and Developmental Biology, 2020 Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang +14 more
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Acta Pharmaceutica Sinica B, 2022 Parkin, an E3 ubiquitin ligase, plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy. Accumulating evidence suggests that the acetylation modification of the key mitophagy machinery influences ...
Xin Sun +7 more
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Parkin is protective against proteotoxic stress in a transgenic zebrafish model. [PDF]
PLoS ONE, 2010 Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial ...
Mareike E Fett +7 more
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Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells
Current Issues in Molecular Biology, 2022 Parkin is a well-established synergistic mediator of mitophagy in dysfunctional mitochondria. Mitochondria are the main target of arsenic trioxide (ATO) cytotoxicity, and the effect of mitophagy on ATO action remains unclear.
Zhewen Zhang +8 more
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Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Cell & Bioscience, 2023 Background Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density.
Eun-Young Kim +10 more
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JAMA Neurology, 2013 Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal recessive juvenile-onset and young-onset parkinsonism. The few available detailed neuropathologic reports suggest that homozygous and compound heterozygous parkin mutations are characterized by severe substantia nigra pars compacta neuronal loss.To investigate whether ...
Doherty, K +15 more
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Parkin Promotes Airway Inflammatory Response to Interferon Gamma
Biomedicines, 2023 Purpose: Increased type 2 interferon (i.e., IFN-γ) signaling has been shown to be involved in airway inflammation in a subset of asthma patients who often show high levels of airway neutrophilic inflammation and poor response to corticosteroid treatment.
Kris Genelyn Dimasuay +4 more
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Post-translational modification of Parkin and its research progress in cancer
Cancer Communications, 2019 Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene, which itself belongs to ...
Dan Ding +7 more
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Journal of Traditional Chinese Medical Sciences, 2020 Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma +9 more
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Parkinson's Disease, 2017 Conventional medical treatments of Parkinson’s disease (PD) are effective on motor disturbances but may have little impact on nonmotor symptoms, especially psychiatric ones.
Giovanni Mirabella +13 more
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