Results 11 to 20 of about 40,126 (261)
Parkin structure and function [PDF]
FEBS Journal, 2015 Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson's disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway.
Kalle Gehring, Guennadi Kozlov
exaly +3 more sources
PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.
PLoS Genetics, 2014 Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated
Kahori Shiba-Fukushima +3 more
doaj +4 more sources
Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice
npj Parkinson's Disease, 2022 Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression. Mutations of mitochondrial E3 ligase, PARKIN, have been associated with juvenile PD.
Nesibe Peker +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) plays a key role in bone formation. Parkin, an E3 ubiquitin ligase, related to Parkinson’s disease and aging. Previous studies have indicated that Parkinson’s disease have a
Wei Zhang +14 more
doaj +1 more source
Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder
Translational Psychiatry, 2021 There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose.
Akhil Sharma +3 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2022 Parkin, an E3 ubiquitin ligase, plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy. Accumulating evidence suggests that the acetylation modification of the key mitophagy machinery influences ...
Xin Sun +7 more
doaj +1 more source
Parkin is protective against proteotoxic stress in a transgenic zebrafish model. [PDF]
PLoS ONE, 2010 Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial ...
Mareike E Fett +7 more
doaj +1 more source
Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells
Current Issues in Molecular Biology, 2022 Parkin is a well-established synergistic mediator of mitophagy in dysfunctional mitochondria. Mitochondria are the main target of arsenic trioxide (ATO) cytotoxicity, and the effect of mitophagy on ATO action remains unclear.
Zhewen Zhang +8 more
doaj +1 more source
Journal of Traditional Chinese Medical Sciences, 2020 Objective: Buyinqianzheng Formula (BYQZF) is clinically employed in traditional Chinese medicine to treat Parkinson’s disease (PD) by improving mitochondrial dysfunction.
Haojie Ma +9 more
doaj +1 more source
Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Cell & Bioscience, 2023 Background Parkin dysfunction associated with the progression of parkinsonism contributes to a progressive systemic skeletal disease characterized by low bone mineral density.
Eun-Young Kim +10 more
doaj +1 more source