Results 11 to 20 of about 59,114 (301)
PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.
PLoS Genetics, 2014 Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated
Kahori Shiba-Fukushima +3 more
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Restriction of trophic factors and nutrients induces PARKIN expression [PDF]
, 2011 Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age. While many details of its pathogenesis remain to be elucidated, in particular the protein and mitochondrial quality control during stress ...
Klinkenberg, Michael +11 more
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Mitophagy in Diabetic Kidney Disease
Frontiers in Cell and Developmental Biology, 2021 Diabetic kidney disease (DKD) is the most common cause of end-stage kidney disease worldwide and is the main microvascular complication of diabetes.
Xiaofeng Zhang +6 more
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Biomedicines, 2023 Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait.
Kyong-hwa Kang +8 more
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Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis [PDF]
, 2015 The PARK2 gene is mutated in 50% of autosomal recessive juvenile parkinsonism (ARJP) cases. It encodes parkin, an E3 ubiquitin ligase of the RBR family.
R Julio Martinez‐Torres +26 more
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Cells, 2021 Parkin and PINK1 are key regulators of mitophagy, an autophagic pathway for selective elimination of dysfunctional mitochondria. To this date, parkin depletion has been associated with recessive early onset Parkinson’s disease (PD) caused by loss-of ...
Katarzyna Gaweda-Walerych +3 more
doaj +1 more source
Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile +70 more
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Biomolecules, 2021 Parkin plays an important role in ensuring efficient mitochondrial function and calcium homeostasis. Parkin-mutant human fibroblasts, with defective oxidative phosphorylation activity, showed high basal cAMP level likely ascribed to increased activity ...
Anna Signorile +8 more
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Parkinson's Disease, 2017 Conventional medical treatments of Parkinson’s disease (PD) are effective on motor disturbances but may have little impact on nonmotor symptoms, especially psychiatric ones.
Giovanni Mirabella +13 more
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Cell Communication and Signaling, 2019 Background Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation.
Dong Hun Lee +6 more
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