Results 11 to 20 of about 44,057 (302)

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity [PDF]

Open Biology, 2014
Mutations in PINK1 and Parkin are associated with early-onset Parkinson's disease. We recently discovered that PINK1 phosphorylates Parkin at serine65 (Ser65) within its Ubl domain, leading to its activation in a substrate-free activity assay.
Agne Kazlauskaite, Van Kelly, Clare Johnson, Carla Baillie, C. James Hastie, Mark Peggie, Thomas Macartney, Helen I. Woodroof, Dario R. Alessi, Patrick G. A. Pedrioli, Miratul M. K. Muqit   +10 more
doaj   +2 more sources

Parkin structure and function [PDF]

FEBS Journal, 2015
Mutations in the parkin or PINK1 genes are the leading cause of the autosomal recessive form of Parkinson's disease. The gene products, the E3 ubiquitin ligase parkin and the serine/threonine kinase PINK1, are neuroprotective proteins, which act together in a mitochondrial quality control pathway.
Guennadi Kozlov, Kalle Gehring
exaly   +3 more sources

PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.

PLoS Genetics, 2014
Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated
Kahori Shiba-Fukushima, Tsuyoshi Inoshita, Nobutaka Hattori, Yuzuru Imai   +3 more
doaj   +4 more sources

Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

eLife
Loss-of-function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by the PINK1 kinase. Herein, we demonstrate a
Dipti Ranjan Lenka, Shakti Virendra Dahe, Odetta Antico, Pritiranjan Sahoo, Alan R Prescott, Miratul MK Muqit, Atul Kumar   +6 more
doaj   +2 more sources

Parkin protects against traumatic brain injury through regulating mitochondrial quality control [PDF]

Neurotherapeutics
Traumatic brain injury (TBI) is a critical neurological condition, with neuronal damage being its fundamental pathological basis. However, molecular targets for the prevention and treatment of neuronal injury remain to be further explored.
Xiuquan Wu, Weihao Lv, Hongqing Chen, Yihao Fu, Xiaowei Fei, Yanan Dou, Peng Luo, Yang Yu, Zhanfeng Niu, Yu Huan, Jialiang Wei, Jimeng Zhang, Chenchen Ji, Sanzhong Li, Yuefei Zhou, Yunchao Yuan, Wangshu Chao, Yaowen Luo, Changcai Xie, Yujie Qiang, Hao Chang, Dakuan Gao, Xia Li   +22 more
doaj   +2 more sources

Correction: Erythropoietin mitigates diabetic nephropathy by restoring PINK1/Parkin-mediated mitophagy. [PDF]

Front Pharmacol
Yi X, Yan W, Guo T, Liu N, Wang Z, Shang J, Wei X, Cui X, Sun Y, Ren S, Chen L.   +10 more
europepmc   +3 more sources

FGF21-Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3. [PDF]

Aging Cell
Wu ZL, Ran R, Xie QQ, Zhang C, Chen YJ, Cheng P, Wang KP, Zhang HH.   +7 more
europepmc   +2 more sources

Efficacy of nicotiflorin in ameliorating septic acute kidney injury: the role of PINK1/parkin in mitochondrial restoration and oxidative stress reduction. [PDF]

Ren Fail
Yang Z, Zhou X, Wu C, Lin X.
europepmc   +2 more sources

Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice

npj Parkinson's Disease, 2022
Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression. Mutations of mitochondrial E3 ligase, PARKIN, have been associated with juvenile PD.
Nesibe Peker, Mridula Sharma, Ravi Kambadur   +2 more
doaj   +1 more source

Parkin regulates drug-taking behavior in rat model of methamphetamine use disorder

Translational Psychiatry, 2021
There is no FDA-approved medication for methamphetamine (METH) use disorder. New therapeutic approaches are needed, especially for people who use METH heavily and are at high risk for overdose.
Akhil Sharma, Arman Harutyunyan, Bernard L. Schneider, Anna Moszczynska   +3 more
doaj   +1 more source