Results 31 to 40 of about 23,205 (164)

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control [PDF]

Cell Death & Disease, 2016
AbstractMitochondrial dysfunction has been linked to the pathogenesis of a large number of inherited diseases in humans, including Parkinson’s disease, the second most common neurodegenerative disorder. The Parkinson’s disease genes pink1 and parkin, which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively ...
Zhuang, Na, Li, Lin, Chen, She, Wang, Tao   +3 more
openaire   +2 more sources

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo [PDF]

Open Biology, 2018
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and defined how this dyad orchestrates the elimination of damaged ...
Thomas G. McWilliams, Erica Barini, Risto Pohjolan-Pirhonen, Simon P. Brooks, François Singh, Sophie Burel, Kristin Balk, Atul Kumar, Lambert Montava-Garriga, Alan R. Prescott, Sidi Mohamed Hassoun, François Mouton-Liger, Graeme Ball, Rachel Hills, Axel Knebel, Ayse Ulusoy, Donato A. Di Monte, Jevgenia Tamjar, Odetta Antico, Kyle Fears, Laura Smith, Riccardo Brambilla, Eino Palin, Miko Valori, Johanna Eerola-Rautio, Pentti Tienari, Olga Corti, Stephen B. Dunnett, Ian G. Ganley, Anu Suomalainen, Miratul M. K. Muqit   +30 more
doaj   +1 more source

Mechanism of parkin activation by PINK1 [PDF]

Nature, 2018
Mutations in the E3 ubiquitin ligase parkin (PARK2, also known as PRKN) and the protein kinase PINK1 (also known as PARK6) are linked to autosomal-recessive juvenile parkinsonism (AR-JP)1,2; at the cellular level, these mutations cause defects in mitophagy, the process that organizes the destruction of damaged mitochondria3,4.
Gladkova, Christina, Maslen, Sarah L., Skehel, J. Mark, Komander, David   +3 more
openaire   +2 more sources

PINK1, cancer and neurodegeneration

Oncoscience, 2016
Cancer and neurodegeneration are two age-related diseases that arise from aberrant signaling in similar cellular systems, those that balance survival and death. Thus, deregulated molecular processes such as DNA damage repair, intracellular energy balance, and key signal transduction systems, including the PI3-kinase/Akt axis can promote tumorigenesis ...
Ciara H, O'Flanagan, Vanessa A, Morais, Cora, O'Neill   +2 more
openaire   +2 more sources

PINK1 points Parkin to mitochondria [PDF]

Autophagy, 2010
For decades, it has been presumed that mitochondrial dysfunction, in the form of impaired complex I activity, may contribute to the cause of Parkinson disease (PD). ( 1) The discovery that several gene mutations cause familial forms of PD ( 1) has led to a renewed enthusiasm for the mitochondrial hypothesis of PD, but this time from a quite distinct ...
Cristofol, Vives-Bauza, Serge, Przedborski   +1 more
openaire   +2 more sources

Interaction of PINK1 with nucleotides and kinetin

Science Advances, 2023
The ubiquitin kinase PINK1 accumulates on damaged mitochondria to trigger mitophagy, and PINK1 loss-of-function mutations cause early onset Parkinson’s disease. Nucleotide analogs such as kinetin triphosphate (KTP) were reported to enhance PINK1 activity and may represent a therapeutic strategy for the treatment of Parkinson’s ...
Zhong Yan Gan, Sylvie Callegari, Thanh N. Nguyen, Nicholas S Kirk, Andrew Leis, Michael Lazarou, Grant Dewson, David Komander   +7 more
openaire   +3 more sources

The effect of 4 weeks of continuous aerobic training with different volumes and starvation on the expression of some genes involved in liver mitophagy in healthy male Wistar rats [PDF]

ورزش و علوم زیست حرکتی
Introduction and Purpose: An increase in the number of defective mitochondria and their persistence can lead to apoptosis and necrosis of cells. Regular physical exercise along with time-restricted eating (TRE) can play an important role in improving ...
Hamzeh Bayani, Habib Asgharpour, Asra Askari, Reza Rezaeshirazi   +3 more
doaj   +1 more source

Function and Characteristics of PINK1 in Mitochondria [PDF]

Oxidative Medicine and Cellular Longevity, 2013
Mutations in phosphatase and tensin homologue-induced kinase 1 (PINK1) cause recessively inherited Parkinson’s disease, a neurodegenerative disorder linked to mitochondrial dysfunction. Studies support the notion of neuroprotective roles for the PINK1, as it protects cells from damage-mediated mitochondrial dysfunction, oxidative stress, and cell ...
Satoru Matsuda, Yasuko Kitagishi, Mayumi Kobayashi   +2 more
openaire   +2 more sources

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation [PDF]

Acta Neuropathologica Communications, 2020
Abstract Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitochondria, thus fine-tuning ...
Peter M. J. Quinn, Paula I. Moreira, António Francisco Ambrósio, C. Henrique Alves   +3 more
openaire   +5 more sources

Structural determinants of PINK1 topology and dual subcellular distribution

BMC Cell Biology, 2010
Background PINK1 is a mitochondria-targeted kinase that constitutively localizes to both the mitochondria and the cytosol. The mechanism of how PINK1 achieves cytosolic localization following mitochondrial processing remains unknown.
Kang Un, Lin William
doaj   +1 more source