Results 11 to 20 of about 23,205 (164)
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 [PDF]
Open Biology, 2012 Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly ...
Chandana Kondapalli +2 more
exaly +2 more sources
Physical exercise as a precision strategy for targeted PINK1 recruitment- a mechanistic review [PDF]
Frontiers in PhysiologyPTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine kinase that orchestrates ubiquitin-dependent mitophagy together with the E3 ligase Parkin.
Jing Zhu, Ligang Tong, Anand Thirupathi
doaj +2 more sources
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.
PLoS Genetics, 2014 Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease.
Ruth E Thomas +4 more
doaj +3 more sources
Cell Reports, 2017 Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson’s disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental
Chang-Ki Oh +2 more
exaly +3 more sources
Activation mechanism of PINK1 [PDF]
Nature, 2021 Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson's disease1,2. PINK1 has many unique features that enable it to phosphorylate ubiquitin and the ubiquitin-like domain of Parkin3-9.
Zhong Yan Gan +11 more
openaire +3 more sources
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA).
DING Gaofeng +3 more
doaj +1 more source
MiRNA-1976 Regulates the Apoptosis of Dopaminergic Neurons by Targeting the PINK1 Gene
Journal of Integrative Neuroscience, 2023 Introduction: Parkinson’s disease (PD), which is a neurodegenerative disease, requires urgently needed biomarkers to explore its mechanism. We screened for differences in the expression of microRNAs (miRNAs) and identified miR-1976 as a possible ...
Feng Qiu +5 more
doaj +1 more source
Autophagy Reports, 2022 Differentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are ...
Priyanka Gajwani, Jalees Rehman
doaj +1 more source
Frontiers in Bioscience-Landmark, 2021 Background: Mitochondrial dysfunction plays a crucial role in Parkinson’s disease (PD) pathogenesis. The present study was undertaken to investigate the effects of Telmisartan (TEL), an angiotensin II type 1 receptor (AT1R) blocker, on the mitochondria ...
Bipul Ray +7 more
doaj +1 more source
Redox Report, 2021 Objectives: High dose-rate ionizing radiation (IR) causes severe DSB damage, as well as reactive oxygen species (ROS) accumulation and oxidative stress.
Qingmei Meng +3 more
doaj +1 more source