Results 11 to 20 of about 38,037 (258)
Activation mechanism of PINK1 [PDF]
Nature, 2021 Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson's disease1,2. PINK1 has many unique features that enable it to phosphorylate ubiquitin and the ubiquitin-like domain of Parkin3-9.
Zhong Yan Gan +2 more
exaly +4 more sources
Regulation of mitochondrial permeability transition pore by PINK1 [PDF]
Molecular Neurodegeneration, 2012 Background: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Caballero, Erica +7 more
core +7 more sources
Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand [PDF]
Cell Metabolism, 2018 Dysregulated mitophagy has been linked to Parkinson’s disease (PD) due to the role of PTEN-induced kinase 1 (PINK1) in mediating depolarization-induced mitophagy in vitro.
Thomas G McWilliams +2 more
exaly +6 more sources
Mechanism of parkin activation by PINK1 [PDF]
Nature, 2018 Mutations in the E3 ubiquitin ligase parkin (PARK2, also known as PRKN) and the protein kinase PINK1 (also known as PARK6) are linked to autosomal-recessive juvenile parkinsonism (AR-JP)1,2; at the cellular level, these mutations cause defects in mitophagy, the process that organizes the destruction of damaged mitochondria3,4.
David Komander
exaly +3 more sources
PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
PLoS Genetics, 2014 Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease. Previous work has shown that PINK1 is constitutively degraded in healthy cells, but selectively accumulates on the surface of depolarized mitochondria, thereby initiating their autophagic
Ruth E Thomas +4 more
openaire +4 more sources
PINK1 signalling in neurodegenerative disease [PDF]
Essays in Biochemistry, 2021 Abstract PTEN-induced kinase 1 (PINK1) impacts cell health and human pathology through diverse pathways. The strict processing of full-length PINK1 on the outer mitochondrial membrane populates a cytoplasmic pool of cleaved PINK1 (cPINK1) that is constitutively degraded.
Whiten, Daniel R +2 more
openaire +2 more sources
Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the expression of mitochondrial autophagy-associated protein PINK1 and Parkin in parotid pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma(CA-EX-PA).
DING Gaofeng +3 more
doaj +1 more source
MiRNA-1976 Regulates the Apoptosis of Dopaminergic Neurons by Targeting the PINK1 Gene
Journal of Integrative Neuroscience, 2023 Introduction: Parkinson’s disease (PD), which is a neurodegenerative disease, requires urgently needed biomarkers to explore its mechanism. We screened for differences in the expression of microRNAs (miRNAs) and identified miR-1976 as a possible ...
Feng Qiu +5 more
doaj +1 more source
Autophagy Reports, 2022 Differentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are ...
Priyanka Gajwani, Jalees Rehman
doaj +1 more source
Frontiers in Bioscience-Landmark, 2021 Background: Mitochondrial dysfunction plays a crucial role in Parkinson’s disease (PD) pathogenesis. The present study was undertaken to investigate the effects of Telmisartan (TEL), an angiotensin II type 1 receptor (AT1R) blocker, on the mitochondria ...
Bipul Ray +7 more
doaj +1 more source