Results 21 to 30 of about 23,381 (243)
Frontiers in Bioscience-Landmark, 2022 Background: Proteinuria is an important symptom of chronic kidney disease irrespective of its initial pathogenesis. Mitochondrial dysfunction is an early pathophysiological event in proteinuria-induced tubular damage. Mitophagy, the selective degradation
Pengpeng Duan +3 more
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PINK1 signalling in neurodegenerative disease [PDF]
Essays in Biochemistry, 2021 Abstract PTEN-induced kinase 1 (PINK1) impacts cell health and human pathology through diverse pathways. The strict processing of full-length PINK1 on the outer mitochondrial membrane populates a cytoplasmic pool of cleaved PINK1 (cPINK1) that is constitutively degraded.
Whiten, Daniel R +2 more
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Redox Report, 2021 Objectives: High dose-rate ionizing radiation (IR) causes severe DSB damage, as well as reactive oxygen species (ROS) accumulation and oxidative stress.
Qingmei Meng +3 more
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PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1 [PDF]
Parkinson's Disease, 2011 Recent publications suggest that the Parkinson's disease- (PD-) related PINK1/Parkin pathway promotes elimination of dysfunctional mitochondria by autophagy. We used tandem affinity purification (TAP), SDS-PAGE, and mass spectrometry as a first step towards identification of possible substrates for PINK1.
Rakovic, Aleksandar +6 more
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PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 [PDF]
Open Biology, 2012 Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly ...
Chandana Kondapalli +12 more
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Neuron, 2006 Mutations in the PTEN-induced putative kinase 1 (PINK1) are a common cause of autosomal recessive Parkinson's disease. In a recent issue of Nature, two independent reports by and show that loss of Drosophila PINK1 leads to defects in mitochondrial function resulting in male sterility, apoptotic muscle degeneration, and minor loss of dopamine neurons ...
Tan, Jeanne M.M., Dawson, Ted M.
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PINK1 in mitochondrial function [PDF]
Proceedings of the National Academy of Sciences, 2008 Rare, inherited mutations causing familial forms of Parkinson's disease (PD) have provided much insight into some of the molecular mechanisms that underlie both the genetic and sporadic forms of the disease. The role of mitochondria in sporadic PD has been debated for a little over 20 years, since the identification of complex I deficiency in the ...
Helene, Plun-Favreau, John, Hardy
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Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity [PDF]
Open Biology, 2014 Mutations in PINK1 and Parkin are associated with early-onset Parkinson's disease. We recently discovered that PINK1 phosphorylates Parkin at serine65 (Ser65) within its Ubl domain, leading to its activation in a substrate-free activity assay.
Agne Kazlauskaite +10 more
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Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease
Cells, 2020 The pathogenesis of Parkinson’s disease (PD), the second most common neurodegenerative disorder, is complex and involves the impairment of crucial intracellular physiological processes.
Lara Sironi +4 more
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PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control [PDF]
Cell Death & Disease, 2016 AbstractMitochondrial dysfunction has been linked to the pathogenesis of a large number of inherited diseases in humans, including Parkinson’s disease, the second most common neurodegenerative disorder. The Parkinson’s disease genes pink1 and parkin, which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively ...
Zhuang, Na +3 more
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